Advances in Wearable Biosensors for Wound Healing and Infection Monitoring
Biosensors,
Год журнала:
2025,
Номер
15(3), С. 139 - 139
Опубликована: Фев. 23, 2025
Wound
healing
is
a
complicated
biological
process
that
important
for
restoring
tissue
integrity
and
function
after
injury.
Infection,
usually
due
to
bacterial
colonization,
significantly
complicates
this
by
hindering
the
course
of
enhancing
chances
systemic
complications.
Recent
advances
in
wearable
biosensors
have
transformed
wound
care
making
real-time
monitoring
biomarkers
such
as
pH,
temperature,
moisture,
infection-related
metabolites
like
trimethylamine
uric
acid.
This
review
focuses
on
recent
biosensor
technologies
designed
management.
Novel
sensor
architectures,
flexible
stretchable
electronics,
colorimetric
patches,
electrochemical
platforms,
enable
non-invasive
detection
changes
associated
with
wounds
high
specificity
sensitivity.
These
are
increasingly
combined
AI
analytics
based
smartphones
can
timely
personalized
interventions.
Examples
PETAL
patch
applies
multiple
sensing
mechanisms
wide-ranging
views
status
closed-loop
systems
connect
therapeutic
devices
automate
infection
control.
Additionally,
self-powered
tap
into
body
heat
or
energy
from
biofluids
themselves
avoid
any
external
batteries
thus
more
effective
field
use
limited
resources.
Internet
Things
connectivity
allows
further
support
remote
sharing
data,
supporting
telemedicine
applications.
Although
developed
relatively
rapidly
their
prospects
continue
expand,
regular
clinical
application
stalled
significant
challenges
regulatory,
cost,
patient
compliance,
technical
problems
related
accuracy,
biofouling,
power,
among
others,
need
be
addressed
innovative
solutions.
The
goal
synthesize
current
trends,
challenges,
future
directions
monitoring,
emphasis
potential
improve
outcomes
reduce
healthcare
burdens.
innovations
leading
way
toward
next-generation
bridging
advanced
materials
science,
biotechnology,
digital
health.
Язык: Английский
Chronic lymphocytic leukemia (CLL) screening and abnormality detection based on multi-layer fluorescence imaging signal enhancement and compensation
Journal of Cancer Research and Clinical Oncology,
Год журнала:
2025,
Номер
151(3)
Опубликована: Март 11, 2025
Fluorescence
in
situ
hybridization
(FISH)
plays
a
critical
role
cancer
screening
but
faces
challenges
signal
clarity
and
manual
intervention.
This
study
aims
to
enhance
FISH
clarity,
improve
efficiency,
reduce
false
negatives
through
an
automated
image
acquisition
enhancement
framework.
An
workflow
was
developed,
integrating
dynamic
method
that
optimizes
global
local
features.
improved
Cycle-GAN
network
introduced,
incorporating
residual
connections
layer-wise
supervision
accurately
model
compensate
for
complex
characteristics.
Key
metrics
such
as
brightness,
edge
gradients,
contrast
improvement
index
(CII),
structural
similarity
(SSIM)
were
used
evaluate
performance.
The
proposed
increased
weak
brightness
by
49.02%,
gradients
48.61%,
CII
32.52%.
SSIM
reached
0.996,
indicating
high
fidelity
original
signals.
Visual
analysis
demonstrated
clearer,
more
continuous,
uniform
fluorescence
signals,
effectively
mitigating
fragmentation
uneven
distribution.
These
improvements
reduced
enhanced
genomic
abnormality
detection
accuracy.
significantly
improves
stability,
providing
reliable
support
screening,
detection,
molecular
typing,
prognosis
evaluation,
targeted
treatment
planning.
Язык: Английский
Fluorescent Tools for Imaging Class A G-protein Coupled Receptors
European Journal of Pharmaceutical Sciences,
Год журнала:
2025,
Номер
unknown, С. 107074 - 107074
Опубликована: Март 1, 2025
Язык: Английский
Innovative Micro- and Nano-Architectures in Biomedical Engineering for Therapeutic and Diagnostic Applications
Micromachines,
Год журнала:
2025,
Номер
16(4), С. 419 - 419
Опубликована: Март 31, 2025
The
rapid
evolution
of
micro-
and
nano-architectures
is
revolutionizing
biomedical
engineering,
particularly
in
the
fields
therapeutic
diagnostic
micromechanics.
This
review
explores
recent
innovations
nanostructured
materials
their
transformative
impact
on
healthcare
applications,
ranging
from
drug
delivery
tissue
engineering
to
biosensing
diagnostics.
Key
advances
fabrication
techniques,
such
as
lithography,
3D
printing,
self-assembly,
have
enabled
unprecedented
control
over
material
properties
functionalities
at
microscopic
scales.
These
engineered
architectures
offer
enhanced
precision
targeting
controlled
release
delivery,
foster
cellular
interactions
improve
sensitivity
specificity
devices.
We
examine
critical
design
parameters,
including
biocompatibility,
mechanical
resilience,
scalability,
which
influence
clinical
efficacy
long-term
stability.
also
highlights
translational
potential
current
limitations
bringing
these
laboratory
research
practical
applications.
By
providing
a
comprehensive
overview
trends,
challenges,
future
perspectives,
this
article
aims
inform
inspire
further
development
that
hold
promise
for
advancing
personalized
medicine.
Язык: Английский