Chiral Lewis Acid-Catalyzed Intramolecular [2 + 2] Photocycloaddition: Enantioselective Synthesis of Azaarene-Functionalized Azabicyclo[2.1.1]hexanes and Bicyclo[1.1.1]pentanes
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
We
present
an
asymmetric
intramolecular
[2
+
2]
photocycloaddition
reaction
enabled
by
a
dual
catalyst
system
involving
DPZ
as
photosensitizer
and
chiral
Sc(III)
complex,
leading
to
azaarene-functionalized
2-azabicyclo[2.2.1]hexanes
(aza-BCHs).
The
approach
efficiently
preventing
racemization
during
subsequent
nitrogen-deletion
skeletal
editing
of
aza-BCHs
yield
2-substituted
bicyclo[1.1.1]pentanes
(BCPs).
method
achieves
high
ee
broad
substrate
scope,
including
the
successful
formation
all-carbon
quaternary
stereocenters.
Furthermore,
activation
simple
azaarene
substrates
Lewis
acids
in
photocatalysis
highlights
notable
contribution
this
field.
Язык: Английский
Visible-Light-Mediated Addition Reactions of Sulfur-Containing Reagents with α-Trifluoromethyl Alkenes
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 22, 2025
Herein,
we
described
the
addition
reactions
of
sulfur-containing
reagents
(sodium
sulfinates,
dithiosulfonates)
with
α-trifluoromethyl
alkenes
under
visible
light.
A
series
trifluoromethyl
sulfonates
were
synthesized
via
visible-light-induced
radical
reaction
sodium
sulfinates
and
to
obtain
protons
from
solvent.
dithiosulfonated
derivatives
bifunctionalization
dithiosulfonates.This
strategy
has
advantages
mild
conditions,
good
substrate
universality
high
yield
up
99%
yield.
Язык: Английский