Features of Selective Kinase Inhibitors

Chemistry & Biology, Год журнала: 2005, Номер 12(6), С. 621 - 637

Опубликована: Июнь 1, 2005

Язык: Английский

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Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease

Cold Spring Harbor Perspectives in Biology, Год журнала: 2017, Номер 10(1), С. a029314 - a029314

Опубликована: Май 15, 2017

Aaron Buckley and Jerrold R. Turner Departments of Pathology Medicine (Gastroenterology), Brigham Women's Hospital Harvard Medical School, Boston, Massachusetts 02115 Correspondence: jrturner{at}bwh.harvard.edu

Язык: Английский

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Pharmacological inhibitors of glycogen synthase kinase 3

Trends in Pharmacological Sciences, Год журнала: 2004, Номер 25(9), С. 471 - 480

Опубликована: Авг. 4, 2004

Язык: Английский

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Targeting JNK for therapeutic benefit: from junk to gold?

Nature Reviews Drug Discovery, Год журнала: 2003, Номер 2(7), С. 554 - 565

Опубликована: Июнь 19, 2003

Язык: Английский

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Protein Kinase G from Pathogenic Mycobacteria Promotes Survival Within Macrophages

Science, Год журнала: 2004, Номер 304(5678), С. 1800 - 1804

Опубликована: Май 25, 2004

Pathogenic mycobacteria resist lysosomal delivery after uptake into macrophages, allowing them to survive intracellularly. We found that the eukaryotic-like serine/threonine protein kinase G from pathogenic was secreted within macrophage phagosomes, inhibiting phagosome-lysosome fusion and mediating intracellular survival of mycobacteria. Inactivation by gene disruption or chemical inhibition resulted in localization mycobacterial cell death infected macrophages. Besides identifying a target for control infections, these findings suggest have evolved signal transduction mechanisms capable modulating host trafficking pathways.

Язык: Английский

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