Recent advances in nanotechnology for Parkinson’s disease: diagnosis, treatment, and future perspectives
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 22, 2025
Parkinson’s
disease
is
a
progressive
neurodegenerative
that
destroys
substantia
nigra
dopaminergic
neurons,
causing
tremors,
bradykinesia,
rigidity,
and
postural
instability.
Current
treatment
approaches
primarily
focus
on
symptom
management,
employing
pharmacological,
non-pharmacological,
surgical
methods.
However,
these
treatments
often
result
in
fluctuating
symptoms,
side
effects,
progression.
Here,
the
authors
have
reviewed
emerging
field
of
nanomedicine
as
promising
path
for
treatment,
emphasizing
its
potential
to
overcome
limitations
traditional
therapies.
Nanomedicine
utilizes
nanoparticles
targeted
drug
delivery,
leveraging
their
small
size
high
surface
area
volume
ratio
cross
blood-brain
barrier
deliver
therapeutic
agents
directly
affected
brain
regions.
Various
nanoparticles,
including
lipid-based,
polymeric,
metallic,
carbon-based,
shown
treatment.
Additionally,
nanocarrier
systems
like
liposomes,
nanogels,
dendrimers,
solid
lipid
offer
controlled
sustained
release
agents,
enhancing
bioavailability
reducing
effects.
This
review
provides
insights
into
pathophysiology
disease,
highlighting
mechanisms
neurodegeneration,
role
alpha-synuclein,
disruption
pathways.
It
further
discusses
application
gene
therapy
conjunction
with
interventions.
Язык: Английский
Nanoparticles induced neurotoxicity
Nanotoxicology,
Год журнала:
2025,
Номер
unknown, С. 1 - 28
Опубликована: Апрель 16, 2025
The
early
development
of
nanotechnology
has
spurred
major
interest
on
the
toxicity
nanoparticles
(NPs)
due
to
their
ability
penetrate
biological
barriers
such
as
BBB.
This
review
aims
at
addressing
how
silver
(AgNPs),
titanium
dioxide
(TiO2NPs),
zinc
oxide
(ZnONPs),
iron
(Fe3O4NPs),
carbon
NPs,
Copper
(Cu-NPs),
silicon
(SiO2
NPs)
and
quantum
dots
cause
neurotoxicity.
Some
signaling
that
occur
are
related
oxidative
stress,
neuroinflammation,
mitochondrial
dysfunction
cell
equilibrium,
hence
results
in
neuronal
damage
neurodegeneration.
It
is
critical
describe
there
multiple
ways
by
NPs
may
be
toxic
based
size
surface,
dosage,
recipient's
age
health
condition.
A
vitro
vivo
analysis
provides
information
about
potentials
preventive
measures
including
modification
NP
surface
antioxidant
treatment.
underline
necessity
comprehensive
safety
assessments
allow
further
utilization
across
economy.
Язык: Английский