High-Resolution Reconstruction of a C. elegans Ribosome Sheds Light on Evolutionary Dynamics and Tissue Specificity DOI
Enisha Sehgal, Chloe Wohlenberg, Evan M. Soukup

и другие.

RNA, Год журнала: 2024, Номер 30(11), С. 1513 - 1528

Опубликована: Авг. 29, 2024

Caenorhabditis elegans is an important model organism for human health and disease, with foundational contributions to the understanding of gene expression tissue patterning in animals. An invaluable tool modern research presence a high-resolution ribosome structure, though no such structure exists C. . Here, we present single-particle cryogenic electron microscopy (cryo-EM) reconstruction molecular ribosome, revealing significantly streamlined animal ribosome. Many facets are conserved , including overall ribosomal architecture mechanism cycloheximide, whereas other facets, as expansion segments eL28, rapidly evolving. We identify uL5 uL23 two instances tissue-specific protein paralog suggesting that ribosomes vary across tissues. The will provide basis future structural, biochemical, genetic studies translation this system.

Язык: Английский

Elucidating the exopolysaccharide biosynthesis in Pediococcus acidilactici BCB1H regulated by iron (Fe2+) using a multi-omics approach DOI
Gege Hu,

Hangyu Hu,

Zengjia Zhou

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142915 - 142915

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Role of MicroRNAs in Acute Myeloid Leukemia DOI Open Access
Aneta Wiśnik, Dariusz Jarych, Kinga Krawiec

и другие.

Genes, Год журнала: 2025, Номер 16(4), С. 446 - 446

Опубликована: Апрель 11, 2025

MicroRNA (miRNA), a significant class of regulatory non-coding RNA (ncRNA), can regulate the expression numerous protein-coding messenger RNAs (mRNAs). miRNA plays an important part in shaping human transcriptome. So far, genome, about 2500 miRNAs have been found. Acute myeloid leukemia (AML) belongs to malignant clonal disorder hematopoietic stem cells and is characterized by uncontrolled proliferation abnormal progenitor bone marrow blood. For past several years, scientific attention has attracted role AML, since alterations levels may contribute AML development. This review describes main functions classes presents biogenesis. study aims recent reports altered microRNA their influence on cell survival, cycle, apoptotic potential. Additionally, it summarizes correlations between target mRNAs outlines particular subtypes according ELN recommendations.

Язык: Английский

Процитировано

0
High-Resolution Reconstruction of a C. elegans Ribosome Sheds Light on Evolutionary Dynamics and Tissue Specificity DOI
Enisha Sehgal, Chloe Wohlenberg, Evan M. Soukup

и другие.

RNA, Год журнала: 2024, Номер 30(11), С. 1513 - 1528

Опубликована: Авг. 29, 2024

Caenorhabditis elegans is an important model organism for human health and disease, with foundational contributions to the understanding of gene expression tissue patterning in animals. An invaluable tool modern research presence a high-resolution ribosome structure, though no such structure exists C. . Here, we present single-particle cryogenic electron microscopy (cryo-EM) reconstruction molecular ribosome, revealing significantly streamlined animal ribosome. Many facets are conserved , including overall ribosomal architecture mechanism cycloheximide, whereas other facets, as expansion segments eL28, rapidly evolving. We identify uL5 uL23 two instances tissue-specific protein paralog suggesting that ribosomes vary across tissues. The will provide basis future structural, biochemical, genetic studies translation this system.

Язык: Английский

Процитировано

0