Association between the dietary index for gut microbiota and cardiometabolic multimorbidity: systemic immune-inflammation index and systemic inflammatory response index DOI Creative Commons

Sihan Hu,

Jiheon Song, Hui Jiang

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Июнь 5, 2025

Objective This study targets to investigate the connection between possibility of Cardiometabolic Multimorbidity (CMM) and Dietary Index for Gut Microbiota (DI-GM), paying special attention mediating roles systemic inflammatory markers, specifically Systemic Immune-Inflammation (SII) Inflammatory Response (SIRI). Methods A cross-sectional was conducted involving 17,388 eligible participants from National Health Nutrition Examination Survey (NHANES) spanning 2007 2020. Weighted logistic regression model employed assess correlation DI-GM, SII, SIRI, CMM. Additionally, restricted cubic spline (RCS) utilized any potential nonlinear relationships these variables risk The degree which SII SIRI mediated link CMM DI-GM assessed using mediation analysis. sensitivity subgroup analyses were confirm results. Results lower markedly correlated with higher scores (OR = 0.94, 95% CI: 0.91–0.98, p 0.001). An elevated linked levels Ln-SII Ln-SIRI 1.45, 1.28–1.65, < 0.001; OR 1.87, 1.69–2.07, Higher education associated a stronger protective effect on CMM, according analysis ( P interaction 0.05). accounted 8.3 18.1% total effect, respectively, partially Sensitivity proved stability findings. Conclusion According study’s findings, could mitigate danger Reduced inflammation acted as partial factor in this connection. These findings highlight mechanisms gut microbiota nutritional perspective. offers insightful information clinical therapy prevention.

Язык: Английский

Mechanisms of inflammatory microenvironment formation in cardiometabolic diseases: molecular and cellular perspectives DOI Creative Commons
Menghua Liu, Rumeng Chen,

Zhiwei Zheng

и другие.

Frontiers in Cardiovascular Medicine, Год журнала: 2025, Номер 11

Опубликована: Янв. 14, 2025

Cardiometabolic diseases (CMD) are leading causes of death and disability worldwide, with complex pathophysiological mechanisms in which inflammation plays a crucial role. This review aims to elucidate the molecular cellular within inflammatory microenvironment atherosclerosis, hypertension diabetic cardiomyopathy. In oxidized low-density lipoprotein (ox-LDL) pro-inflammatory cytokines such as Interleukin-6 (IL-6) Tumor Necrosis Factor-alpha (TNF-α) activate immune cells contributing foam cell formation arterial wall thickening. Hypertension involves activation renin-angiotensin system (RAS) alongside oxidative stress-induced endothelial dysfunction local mediated by T cells. cardiomyopathy, high-glucose environment leads accumulation advanced glycation end products (AGEs), activating Receptor for Advanced Glycation Endproducts (RAGE) triggering responses that further damage cardiac microvascular function. summary, different types metabolic cardiovascular diverse; understanding these deeply will aid developing more effective individualized treatment strategies.

Язык: Английский

Процитировано

3
Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions DOI Creative Commons

Enzo Pereira de Lima,

Masaru Tanaka,

Caroline Barbalho Lamas

и другие.

Biomedicines, Год журнала: 2024, Номер 12(9), С. 2096 - 2096

Опубликована: Сен. 13, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the mass reduction seen in sarcopenia neuronal function characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review analyzes interrelated mechanisms contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting characterized by atrophy weakness. dysfunction have negative physical quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing integrated therapies improving muscular well-being. Better links can refine strategies yield better patient outcomes. study emphasizes complex interplay between dysfunction, degeneration, decline, highlighting necessity for multidisciplinary Advances domain promise improved diagnostic accuracy, more options, enhanced preventive measures, all contributing higher life elderly population.

Язык: Английский

Процитировано

7
Angiotensin III activates ERK1/2 mitogen activated protein kinases and proliferation of rat vascular smooth muscle cells DOI
Ahmed Z. Alanazi, Michelle A. Clark

Journal of Receptors and Signal Transduction, Год журнала: 2025, Номер unknown, С. 1 - 12

Опубликована: Янв. 13, 2025

The proliferative effects of angiotensin (Ang) II in vascular smooth muscle cells (VSMCs) through its ability to stimulate extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathway have been established. main goal this study was explore whether Ang III induces ERK1/2 MAPK VSMC proliferation cultured Wistar VSMCs. Further, the actions were compared those observed VSMCs derived from spontaneously hypertensive rat (SHR). We hypothesized that will similar as induce cellular may be different isolated versus SHR rats. Time and/or concentration-dependent determined using western blot analysis DNA incorporation assay. results showed phosphorylation mediated by or concentration- time-dependent Moreover, less effective mediating seen induced AT1 receptors activation. synthesis via receptor a manner significant differences existed peptide's These indicate stimulates receptors. However, these pathways is reduced

Язык: Английский

Процитировано

1
The Role of the MAPK Signaling Pathway in Cardiovascular Disease: Pathophysiological Mechanisms and Clinical Therapy DOI Open Access
Xueyang Wang, Ruiqi Liu, Dan Liu

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2667 - 2667

Опубликована: Март 16, 2025

Cardiovascular disease (CVD) is a serious global health issue with high mortality rates worldwide. Despite the numerous advancements in study of CVD pathogenesis recent years, further summarization and elaboration specific molecular pathways are required. An extensive body research has been conducted to elucidate association between MAPK signaling pathway, which present all eukaryotic organisms, cardiovascular disease. This review aims provide comprehensive summary on over past five years. The primary focus four diseases: heart failure, atherosclerosis, myocardial ischemia–reperfusion injury, cardiac hypertrophy. will also address pathophysiological mechanisms diseases, objective proposing novel clinical treatment strategies for CVD.

Язык: Английский

Процитировано

1
Pathophysiology of Angiotensin II-Mediated Hypertension, Cardiac Hypertrophy, and Failure: A Perspective from Macrophages DOI Creative Commons
Kelly Carter,

Eshan Shah,

Jessica Waite

и другие.

Cells, Год журнала: 2024, Номер 13(23), С. 2001 - 2001

Опубликована: Дек. 4, 2024

Heart failure is a complex syndrome characterized by cardiac hypertrophy, fibrosis, and diastolic/systolic dysfunction. These changes share many pathological features with significant inflammatory responses in the myocardium. Among various regulatory systems that impact on these heterogeneous processes, angiotensin II (Ang II)-activated macrophages play pivotal role induction of subcellular defects adverse remodeling during progression heart failure. Ang stimulates via its AT1 receptor to release oxygen-free radicals, cytokines, chemokines, other mediators myocardium, upregulates expression integrin adhesion molecules both monocytes endothelial cells, leading monocyte-endothelial cell-cell interactions. The transendothelial migration monocyte-derived exerts biological effects proliferation fibroblasts, deposition extracellular matrix proteins, perivascular/interstitial development hypertension, hypertrophy Inhibition macrophage activation using antagonist or depletion from peripheral circulation has shown inhibitory II-induced vascular myocardial injury. purpose this review discuss current understanding maladaptive dysfunction, particularly focusing molecular signaling pathways involved macrophages-mediated In addition, challenges remained translating findings treatment patients are also addressed.

Язык: Английский

Процитировано

3
Relationship Between Carotid Artery Remodeling Characteristics and Early Carotid Atherosclerosis DOI Creative Commons

Yujia Yang,

Hua Yang,

Lingyun Jia

и другие.

Journal of Ultrasound in Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Objectives This study analyzed carotid artery remodeling characteristics in early atherosclerosis (ECAS). Methods The 1021 participants were evaluated using ultrasonography and categorized into three groups: Group A, 391 with increased intima‐media thickness (IMT); B, 300 atherosclerotic plaque only on the bulb (CB); control group (330 participants). ratios of diameters CB to those common ( D CCA ) internal ICA defined as index1 (CI 1 2 ). Results A had a higher , CI than controls P < .05). B smaller Logistic regression showed that was positive influencing factor for IMT (OR: 3.42, 95% CI: 1.74–6.70, .001), negative independent formation 0.11, 0.04–0.28, .001). Multiple linear vessel side significant influence β = 0.055, .05), while age, sex, body mass index, cerebrovascular risk factors no correlation CI. Conclusions IMT, however, formation. changes consistent remodeling. an ECAS, it affected by side, providing objective predictive parameter ECAS.

Язык: Английский

Процитировано

0
Hepatic Arterial Flow-Induced Portal Tract Fibrosis in Portal Hypertension: The Role of VCAM-1 and Osteopontin-Expressing Macrophages DOI Open Access
Ruixue Ma,

Li Gong,

Chao Dong

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

ABSTRACT Background The liver undergoes significant hemodynamic changes during surgery, transplantation, or cirrhosis with portal hypertension(PH). hepatic artery buffer response(HABR), which compensates for reduced venous flow by increasing artery(HA) flow, is hypothesized to induce pathological tract remodeling. This study investigates the molecular mechanisms underlying this process. Methods PH was induced in Sprague-Dawley rats via partial vein ligation(PPVL). Structural evaluation(microCT), immune cell profiling, measurements, and transcriptomic analysis macrophages(Mϕ) from sham PPVL were conducted. Results MicroCT revealed decreased increased HA correlated pressure(r=0.799, p<0.01). A 2-fold increase fibrosis(p<0.001) observed α-SMA+ myofibroblasts rats. CD68+ Mϕ peaked at 10 days post-PPVL, their depletion significantly fibrosis(p<0.001), indicating critical roles of VCAM-1 elevated endothelium fibroblasts (PFs); neutralization collagen accumulation(p<0.05), Mϕ(46.3%, p<0.01), CD3+ T cells(18%, p<0.05). Mϕ-conditioned medium PFs(8-fold, p<0.001) enhanced PF migration, while knockdown effect (p<0.01). Single-cell RNA sequencing data(GSE171904) RNA-FISH interactions between osteopontin (Spp1)+ PFs, Spp1+ driving fibrosis. Spp1 co-culture fibrogenic markers, recombinant upregulated Col1a1, Fn1, Acta2 expression PFs. Conclusion Increased arterial endothelial cells PFs facilitates recruitment Mϕ, drive flow-mediated vascular remodeling These findings highlight flow-induced fibrosis as a key mechanism PH, potentially contributing disease progression decompensation. Synopsis Liver hypertension extracellular matrix accumulation macrophages. highlights how altered blood induces fibrosis, its potential role decompensation, identifies therapeutic targets advanced disease.

Язык: Английский

Процитировано

0
The role of AT-1 antagonist on wound healing in rats with hypertension and diabetes DOI
Margarita García, Thiago José Dionísio, Tânia Mary Cestari

и другие.

Journal of Molecular Histology, Год журнала: 2025, Номер 56(2)

Опубликована: Фев. 8, 2025

Язык: Английский

Процитировано

0
Mechanotransduction in the Perivascular Adipose Tissue DOI
Stephanie W. Watts, Teresa Krieger-Burke, Rance Nault

и другие.

Arteriosclerosis Thrombosis and Vascular Biology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

Perivascular adipose tissue is of compelling interest when considering mechanotransduction. Because its location around a vessel, perivascular experiences from high (artery) to low (vein) pressures, pressures that are cyclical in nature. With blood pressure change, such as the elevation hypertension, question has been raised whether senses changes, evidenced by response can be genetic, structural, or mechanical Here, we briefly review following knowledge and data support ability both (mechano)sense (mechano)respond.

Язык: Английский

Процитировано

0
Physicochemical and spectral investigation of interactions between hydralazine hydrochloride and dextrose in aqueous solutions DOI

Parveen Kumar,

Palak Ahir,

Sunaina Sharma

и другие.

Journal of Molecular Liquids, Год журнала: 2025, Номер unknown, С. 127250 - 127250

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0