BMC Cardiovascular Disorders,
Год журнала:
2024,
Номер
24(1)
Опубликована: Дек. 20, 2024
Triglyceride-glucose
(TyG)
index,
which
is
a
valuable
measure
of
insulin
resistance,
has
been
found
to
have
predictive
value
for
cardiovascular
disease
(CVD).
However,
its
relationship
with
CVD
among
individuals
chronic
kidney
(CKD)
not
thoroughly
investigated.
This
study
focused
on
examining
the
TyG
index
and
CKD
patients
in
United
States.
3507
eligible
participants
from
National
Health
Nutrition
Examination
Survey
(2003–2018)
were
surveyed
this
study.
Methods
such
as
multivariable
logistic
regression
analysis
smooth
curve
fitting
employed
estimate
how
linked
populations.
Subgroup
interaction
analyses
conducted
order
figure
out
potential
moderating
effects
various
factors.
In
cross-sectional
based
population
CKD,
29.5%
also
had
CVD.
An
independent
positive
link
was
revealed
(OR
1.213,
95%
CI
1.059,
1.389).
association
nonlinear,
threshold
effect
observed
at
8.98.
The
results
subgroup
suggested
that
relationships
differed
according
stage:
1.048,
0.857,
1.282)
stages
1–2;
1.267,
1.030–1.560)
stage
3;
2.131,
1.224–3.709)
4–5.
Interaction
further
stage.
Additionally,
specific
types,
only
coronary
heart
(CHD)
significant
1.617,
1.123,
2.327).
identified
be
independently
positively
related
likelihood
CVD,
specifically
populations
an
eGFR
<
60
mL/min/1.73
m².
effect.
highlight
tool
screening
risk
assessment
suffering
warranting
investigation.
Physical Education Theory and Methodology,
Год журнала:
2025,
Номер
25(2), С. 221 - 227
Опубликована: Март 30, 2025
Objectives.
This
study
aimed
to
evaluate
the
long-term
effects
of
endurance
training
as
a
modulator
in
prevention
cardiovascular
disease
risk
obese
individuals.
Materials
and
methods.
used
true
experimental
method
with
pretest-posttest
control
group
design.
Twenty-five
women
aged
20-30
years
body
fat
percentage
≥30%
were
assigned
(CNT)
an
exercise
(EXC).
The
EXC
underwent
eight-week
(three
sessions
per
week)
program
(treadmill)
lasting
40-60
minutes
session.
Blood
pressure
(BP),
mean
arterial
(MAP),
resting
heart
rate
(RHR)
measured
using
OMRON
HBP-9030
digital
tensiometer
Polar
H10
sensor
at
start
(pre)
after
eight
weeks
(post)
training.
Results.
Significant
reductions
systolic
blood
(SBP),
diastolic
(DBP),
MAP,
RHR
detected
between
pre-
post-endurance
phases
(all
p
≤
0.001).
Additionally,
notable
decrease
SBP,
DBP,
was
observed
groups
0.05).
Conclusions.
findings
indicate
effectiveness
intervention,
contributing
consistent
reduction
women.
AbstractObjective:
To
analyze
the
risk
and
influencing
factors
of
coronary
heart
disease
(CHD)
in
patients
with
diabetes
(DM),
to
develop
validate
a
nomogram
prediction
model,
providing
basis
for
early
diagnosis
individualized
intervention
DM
CHD.
Methods:
This
study
is
based
on
data
from
National
Health
Nutrition
Examination
Survey
(NHANES).
A
total
2,141
diabetic
2011
2020
were
included,
randomly
divided
into
training
set
(n=149)
validation
(n=642)
7:3
ratio.
The
least
absolute
shrinkage
selection
operator
(Lasso)
regression
analysis
was
used
screen
factors,
multivariate
logistic
model
developed
construct
DM-CHD
model.
Model
performance
internally
validated
using
Receiver
Operating
Characteristic
(ROC)
curves,
calibration
decision
curve
(DCA).
Results:
Univariate
identified
14
as
DM-related
Lasso
further
selected
7
key
predictors:
age
(OR
1.06,
CI
1.05-1.08,
P<0.001),
gender
0.47,
0.36-0.63,
hypertension
1.85,
1.33-2.57,
weight-adjusted
waist
circumference
index
1.50,
1.25-1.81,
neutrophils
1.09,
1.02-1.17,
P=0.009),
platelets
0.99,
0.99-0.99,
triglycerides
1.18,
1.08-1.30,
P<0.001).
area
under
(AUC)
ROC
0.758
(95%
0.728-0.789)
0.747
0.699-0.796)
set.
Calibration
curves
DCA
indicated
that
had
good
predictive
performance.
model’s
reliability
clinical
net
benefit
validated.
Conclusion:
The
this
study,
multiple
indicators
(age,
gender,
hypertension,
index,
neutrophils,
platelets,
triglycerides),
demonstrated
high
This
has
strong
applicability
can
provide
scientific
evidence
CHD,
potential
reduce
CHD
patients.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 13, 2025
Aortic
dissection
(AD)
is
a
life-threatening
condition
with
high
mortality
rate.
Oxidative
stress
and
endothelial
vascular
smooth
muscle
cell
migration
contribute
to
AD
pathogenesis.
Herein,
we
investigated
the
therapeutic
potential
of
hydrogen
(H2),
delivered
via
magnesium
diboride
nanosheets
(MBNs),
in
murine
model
β-aminopropionitrile-induced
AD.
This
treatment
significantly
improved
survival
rate
reduced
progression,
as
evidenced
by
aortic
wall
structure
false
lumen
formation.
Transcriptomic
analysis
indicated
modulation
RhoA/ROCK
pathway,
confirmed
using
Western
blotting,
immunohistochemistry,
immunofluorescence,
which
showed
significant
downregulation
RhoA
ROCK2
after
28
days
(P
<
0.05).
These
findings
suggest
that
released
from
MBNs
attenuates
progression
through
reactive
oxygen
species
scavenging
pathway
inhibition.
Cells,
Год журнала:
2024,
Номер
13(23), С. 2001 - 2001
Опубликована: Дек. 4, 2024
Heart
failure
is
a
complex
syndrome
characterized
by
cardiac
hypertrophy,
fibrosis,
and
diastolic/systolic
dysfunction.
These
changes
share
many
pathological
features
with
significant
inflammatory
responses
in
the
myocardium.
Among
various
regulatory
systems
that
impact
on
these
heterogeneous
processes,
angiotensin
II
(Ang
II)-activated
macrophages
play
pivotal
role
induction
of
subcellular
defects
adverse
remodeling
during
progression
heart
failure.
Ang
stimulates
via
its
AT1
receptor
to
release
oxygen-free
radicals,
cytokines,
chemokines,
other
mediators
myocardium,
upregulates
expression
integrin
adhesion
molecules
both
monocytes
endothelial
cells,
leading
monocyte-endothelial
cell-cell
interactions.
The
transendothelial
migration
monocyte-derived
exerts
biological
effects
proliferation
fibroblasts,
deposition
extracellular
matrix
proteins,
perivascular/interstitial
development
hypertension,
hypertrophy
Inhibition
macrophage
activation
using
antagonist
or
depletion
from
peripheral
circulation
has
shown
inhibitory
II-induced
vascular
myocardial
injury.
purpose
this
review
discuss
current
understanding
maladaptive
dysfunction,
particularly
focusing
molecular
signaling
pathways
involved
macrophages-mediated
In
addition,
challenges
remained
translating
findings
treatment
patients
are
also
addressed.
Arteriosclerosis Thrombosis and Vascular Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 13, 2025
Perivascular
adipose
tissue
is
of
compelling
interest
when
considering
mechanotransduction.
Because
its
location
around
a
vessel,
perivascular
experiences
from
high
(artery)
to
low
(vein)
pressures,
pressures
that
are
cyclical
in
nature.
With
blood
pressure
change,
such
as
the
elevation
hypertension,
question
has
been
raised
whether
senses
changes,
evidenced
by
response
can
be
genetic,
structural,
or
mechanical
Here,
we
briefly
review
following
knowledge
and
data
support
ability
both
(mechano)sense
(mechano)respond.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 21, 2025
Heart
aging
involves
a
complex
interplay
of
genetic
and
environmental
influences,
leading
to
gradual
deterioration
cardiovascular
integrity
function.
Age-related
physiological
changes,
including
ventricular
hypertrophy,
diastolic
dysfunction,
myocardial
fibrosis,
increased
arterial
stiffness,
endothelial
are
influenced
by
key
mechanisms
like
autophagy,
inflammation,
oxidative
stress.
This
review
aims
explore
the
therapeutic
potential
plant-derived
bioactive
antioxidants
in
mitigating
heart
aging.
These
compounds,
often
rich
polyphenols,
flavonoids,
other
phytochemicals,
exhibit
notable
antioxidant,
anti-inflammatory,
cardioprotective
properties.
substances
have
intricate
properties,
ability
scavenge
ROS,
enhance
endogenous
antioxidant
defenses,
regulate
signaling
pathways,
impede
fibrosis
inflammation-promoting
processes.
By
focusing
on
molecular
linked
cardiac
aging,
produced
from
plants
provide
significant
promise
reduce
age-related
decline
improve
general
health.
Through
comprehensive
analysis
preclinical
clinical
studies,
this
work
highlights
associated
with
promising
effects
antioxidants.
The
findings
may
helpful
for
researchers
identifying
specific
molecules
preventive
heart.
