Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 23, 2024
In
Periodic
Paralysis
(PP),
a
rare
inherited
condition
caused
by
mutation
in
skeletal
muscle
ion
channels,
the
phenotype
changes
with
age,
transitioning
from
episodic
attacks
of
weakness
that
give
its
name,
to
more
degenerative
permanent
progressive
and
myopathy.
This
leads
disability
reduced
quality
life.
Neither
cause
this
transition,
nor
why
it
occurs
around
age
40
is
known.
However,
also
onset
‘normal’
age-related
physiological
decline
when
we
consider
(a)
mass
strength
(b)
physical
function
at
world
class
level
(c)
mitochondrial
dysfunction.
Elevated
Na
+
,
dysfunction
sarcoplasmic
Ca
2+
leak
via
ryanodine
receptor
(RyR1)
have
been
implicated
both
periodic
paralysis
myopathy
ageing.
We
suggest
combination
may
trigger
negative
spiral
ultimately
leading
failure.
Understanding
interaction
between
ageing
physiology
disease
will
provide
window
into
healthy
process
but
help
understand
how,
PP
age.
mechanism
underlying
phenotype-transition
link
physiology,
not
only
has
potential
identify
first
modifying
therapies
for
PP,
novel
potentially
tractable
mechanisms
contribute
sarcopenia,
pathological
loss
Journal of Clinical Medicine,
Год журнала:
2023,
Номер
12(24), С. 7625 - 7625
Опубликована: Дек. 11, 2023
Temporal
muscle
thickness
(TMT)
on
cranial
CT
scans
has
recently
been
identified
as
a
prognostic
imaging
parameter
for
assessing
patient's
baseline
frailty.
Here,
we
analyzed
whether
TMT
correlates
with
Traumatic
brain
injury
(TBI)
severity
and
it
can
be
used
to
predict
outcome(s)
after
TBI.
We
the
radiological
clinical
data
sets
of
193
patients
TBI
who
were
admitted
our
institution
correlated
outcomes
stratification
TMT.
Our
analyses
showed
significant
association
between
high
increased
risk
intracranial
hemorrhage
(p
=
0.0135)
but
improved
mRS
at
6
months
0.001)
compared
low
Congruent
such
findings,
lower
was
associated
falls
reduced
<
0.0001
p
0.0001).
High
robustly
head
trauma
sequelae
also
good
in
patients.
These
findings
consolidate
significance
an
objective
marker
frailty
patients;
measurements
may
ultimately
leveraged
indicators.
Molecular & cellular biomechanics,
Год журнала:
2024,
Номер
21, С. 180 - 180
Опубликована: Авг. 6, 2024
Aging
is
an
intriguing
process
that
fascinates
many
researchers.
This
fascination
related
to
the
impossibility
of
controlling
time
and
its
influence
on
human
beings.
Many
theories
have
been
studied
understand
this
complex
impact
it
has
muscular
system.
The
ability
control
how
reduce
risk
falls,
prevent
illnesses,
improve
quality
life
elderly
encouraged
development
studies
it.
It
known
type
two
fibers
undergo
more
denervation
than
one
during
aging,
as
well
relationship
between
specific
characteristics
their
decline.
However,
some
questions
actually
happened
ideal
exercises
can
enhance
hypertrophy
recruitment
fibers,
although
resistance
training
accepted,
are
not
clear
require
further
focused
issue.
Therefore,
considering
importance
these
2
muscle
in
aging
they
elderly,
objective
study
be
pioneer
collecting
recent
relevant
information
associated
with
kind
fiber,
show
current
gaps
subject
encourage
new
research
seek
knowledge
improves
science.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 20, 2024
Abstract
Sarcopenia
is
the
age-related
degeneration
of
skeletal
muscle,
resulting
in
loss
muscle
tone,
mass,
and
quality.
Skeletal
a
source
systemic
metabolites
macromolecules
important
for
neuronal
health,
function
healthy
aging.
Age-related
might
result
decreased
metabolite
macromolecule
availability,
reduced
or
increased
susceptibility
to
unhealthy
aging
neurodegenerative
diseases.
We
aimed
identify
candidates
that
regulate
C57BL/6J
mice
were
aged
young
adult
(4
months)
old
age
(25
was
collected.
Age
related
confirmed
by
fiber
degeneration,
myosin
intensity,
addition
metabolic
shift
DNA
damage
muscle.
Using
low
molecular
weight
enriched
metabolomics
protocol,
we
assessed
profile
from
identified
20
significantly
changed
These
candidate
tested
C.
elegans
assays
lifespan,
health
span,
muscle-,
mitochondrial
morphology
under
normal
stressed
conditions.
four
(beta-alanine,
4-guanidinobutanoic
acid,
4-hydroxyproline,
pantothenic
acid)
when
supplemented
provided
robust
gero-
protection.
also
affected
life-,
span
models
amyotrophic
lateral
sclerosis
Duchenne
muscular
dystrophy.
Our
findings
support
can
be
used
novel
modulators
lifespan
may
show
promise
future
treatments
neuromuscular
disorders.
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 23, 2024
In
Periodic
Paralysis
(PP),
a
rare
inherited
condition
caused
by
mutation
in
skeletal
muscle
ion
channels,
the
phenotype
changes
with
age,
transitioning
from
episodic
attacks
of
weakness
that
give
its
name,
to
more
degenerative
permanent
progressive
and
myopathy.
This
leads
disability
reduced
quality
life.
Neither
cause
this
transition,
nor
why
it
occurs
around
age
40
is
known.
However,
also
onset
‘normal’
age-related
physiological
decline
when
we
consider
(a)
mass
strength
(b)
physical
function
at
world
class
level
(c)
mitochondrial
dysfunction.
Elevated
Na
+
,
dysfunction
sarcoplasmic
Ca
2+
leak
via
ryanodine
receptor
(RyR1)
have
been
implicated
both
periodic
paralysis
myopathy
ageing.
We
suggest
combination
may
trigger
negative
spiral
ultimately
leading
failure.
Understanding
interaction
between
ageing
physiology
disease
will
provide
window
into
healthy
process
but
help
understand
how,
PP
age.
mechanism
underlying
phenotype-transition
link
physiology,
not
only
has
potential
identify
first
modifying
therapies
for
PP,
novel
potentially
tractable
mechanisms
contribute
sarcopenia,
pathological
loss
