Astrocytes gate long-term potentiation in hippocampal interneurons DOI Open Access
Weida Shen,

Yejiao Tang,

Jing Yang

и другие.

Опубликована: Сен. 27, 2023

Long-term potentiation is involved in physiological process like learning and memory, motor sensory processing, pathological conditions such as addiction. In contrast to the extensive studies on mechanism of long-term excitatory glutamatergic synapse onto neurons (LTP E→E ), LTP inhibitory E→I ) remains largely unknown. central nervous system, astrocytes play an important role regulating synaptic activity participate , but their functions remain incompletely defined. Using electrophysiological, pharmacological, confocal calcium imaging, chemogenetics behavior tests, we studied hippocampal CA1 region impact cognitive function. We show that stratum oriens astrocyte independent. However, radiatum, synaptically released endocannabinoids increases Ca 2+ via type-1 cannabinoid receptors, stimulates D-serine release, potentiate transmission neuron through activation (N-methyl-D-aspartate) NMDA receptors. also revealed chemogentic sufficient induce NMDA-dependent de novo radiatum hippocampus. Furthermore, found disrupt by knockdwon γCaMKII interneurons resulted dramatic memory impairment. Our findings suggest release D-serine, which activates receptors regulate function intricately linked with proper functioning this pathway.

Язык: Английский

Astrocytes gate long-term potentiation in hippocampal interneurons DOI Open Access
Weida Shen,

Yejiao Tang,

Jing Yang

и другие.

Опубликована: Сен. 27, 2023

Long-term potentiation is involved in physiological process like learning and memory, motor sensory processing, pathological conditions such as addiction. In contrast to the extensive studies on mechanism of long-term excitatory glutamatergic synapse onto neurons (LTP E→E ), LTP inhibitory E→I ) remains largely unknown. central nervous system, astrocytes play an important role regulating synaptic activity participate , but their functions remain incompletely defined. Using electrophysiological, pharmacological, confocal calcium imaging, chemogenetics behavior tests, we studied hippocampal CA1 region impact cognitive function. We show that stratum oriens astrocyte independent. However, radiatum, synaptically released endocannabinoids increases Ca 2+ via type-1 cannabinoid receptors, stimulates D-serine release, potentiate transmission neuron through activation (N-methyl-D-aspartate) NMDA receptors. also revealed chemogentic sufficient induce NMDA-dependent de novo radiatum hippocampus. Furthermore, found disrupt by knockdwon γCaMKII interneurons resulted dramatic memory impairment. Our findings suggest release D-serine, which activates receptors regulate function intricately linked with proper functioning this pathway.

Язык: Английский

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