Integration of ATAC-Seq and RNA-Seq Reveals VDR–SELENBP1 Axis Promotes Adipogenesis of Porcine Intramuscular Preadipocytes DOI Open Access
Jiawei Zhou,

Junjing Wu,

Tao Yang

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12528 - 12528

Опубликована: Ноя. 22, 2024

Intramuscular fat (IMF) content plays a crucial role in determining pork quality. Recent studies have highlighted transcriptional mechanisms controlling adipogenesis porcine IMF. However, the changes chromatin accessibility during adipogenic differentiation are still not well understood. In this study, we performed assay for transposase-accessible with high-throughput sequencing (ATAC-seq) and transcriptome (RNA-Seq) analyses on intramuscular preadipocytes to explore their into mature adipocytes. We identified total of 56,374 differentially accessible peaks 4226 expressed genes at day 0 4 differentiation. A combined analysis ATAC-seq RNA-seq data revealed that 1750 exhibited both differential RNA expression process, including selenium-binding protein 1 (

Язык: Английский

Mitochondrial substrate oxidation regulates distinct cell differentiation outcomes DOI
Woo Yong Park,

Claudia Montufar,

Elma Zaganjor

и другие.

Trends in Cell Biology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
ИНФЛАМЭЙДЖИНГ И МЕТАБОЛИЧЕСКИЙ СИНДРОМ: МОЛЕКУЛЯРНЫЕ МЕХАНИЗМЫ DOI
Ivan Pchelin,

К.Ю. Лукьянец,

Е.С. Миронова

и другие.

Успехи геронтологии, Год журнала: 2025, Номер 38(1), С. 118 - 125

Опубликована: Май 18, 2025

Язык: Русский

Процитировано

0
A special issue of Essays in Biochemistry on AMPK and AMPK-related kinases DOI Creative Commons
Ian P. Salt, David Carling

Essays in Biochemistry, Год журнала: 2024, Номер 68(3), С. 269 - 271

Опубликована: Ноя. 1, 2024

Abstract In eukaryotic cells, AMP-activated protein kinase (AMPK) plays a central role in responding to nutrient limitation by switching-off ATP-consuming (anabolic) pathways and switching-on ATP generating (catabolic) pathways. Over the last 30 years or so, considerable body of research has been carried out that provided us with wealth knowledge regarding regulation AMPK. Despite this, there is still much learn about AMPK field remains highly active, many groups around world continuing explore new roles for AMPK, providing insight into its biological function. This review series was inspired recent AMPK-focused meetings Scotland (2022) Australia (2023) draws on some presented at those meetings.

Язык: Английский

Процитировано

0
Integration of ATAC-Seq and RNA-Seq Reveals VDR–SELENBP1 Axis Promotes Adipogenesis of Porcine Intramuscular Preadipocytes DOI Open Access
Jiawei Zhou,

Junjing Wu,

Tao Yang

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12528 - 12528

Опубликована: Ноя. 22, 2024

Intramuscular fat (IMF) content plays a crucial role in determining pork quality. Recent studies have highlighted transcriptional mechanisms controlling adipogenesis porcine IMF. However, the changes chromatin accessibility during adipogenic differentiation are still not well understood. In this study, we performed assay for transposase-accessible with high-throughput sequencing (ATAC-seq) and transcriptome (RNA-Seq) analyses on intramuscular preadipocytes to explore their into mature adipocytes. We identified total of 56,374 differentially accessible peaks 4226 expressed genes at day 0 4 differentiation. A combined analysis ATAC-seq RNA-seq data revealed that 1750 exhibited both differential RNA expression process, including selenium-binding protein 1 (

Язык: Английский

Процитировано

0