Zn2SnO4@SiO2@5-FU Nanoparticles as an Additive for Maxillary Bone Defects DOI Open Access

Ana Maria Gianina Rehner,

Ana‐Maria Bratu, Alexandra Cătălina Bîrcă

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 26(1), С. 194 - 194

Опубликована: Дек. 29, 2024

This study investigates the synthesis of Zn2SnO4@SiO2@5-FU nanoparticles as an additive for bone fillers in dental maxillofacial reconstruction. Zn2SnO4 were synthesized and coated with a SiO2 shell, followed by incorporation 5-Fluorouracil (5-FU), aimed at enhancing therapeutic properties classical fillers. Structural analysis using X-ray diffraction confirmed that was single crystalline phase present, its crystallinity preserved after both coating 5-FU incorporation. SEM characterization revealed micro-spherical particles assembled agglomeration nanorods, exhibiting dimensions morphological characteristics consistent addition shell 5-FU. Fourier-transformed infrared spectroscopy provided solid proof successful Zn2SnO4, Zn2SnO4@SiO2, Zn2SnO4@SiO2@5-FU, confirming presence expected functional groups. The layer improved nanoparticle stability solution, indicated zeta potential measurements, while adding significantly increased biocompatibility targeting efficiency. existence is also hydrodynamic diameter, indicating increase particle size incorporating compounds. Antibacterial assays demonstrated selective efficacy against Gram-positive bacteria, showing strongest inhibitory effects. Biofilm inhibition studies further nanoparticles’ effectiveness preventing bacterial colonization. Cytotoxicity tests on A-431 human epidermoid carcinoma cell line dose-dependent reduction viability, highlighting targeted cancer treatment. These findings highlight multifunctional fillers, offering enhanced antimicrobial antitumor capabilities.

Язык: Английский

Advancements in Materials for 3D-Printed Microneedle Arrays: Enhancing Performance and Biocompatibility DOI Creative Commons
Mahmood Razzaghi,

Joel Alexander Ninan,

Mohsen Akbari

и другие.

Micromachines, Год журнала: 2024, Номер 15(12), С. 1433 - 1433

Опубликована: Ноя. 28, 2024

The rapid advancement of 3D printing technology has revolutionized the fabrication microneedle arrays (MNAs), which hold great promise in biomedical applications such as drug delivery, diagnostics, and therapeutic interventions. This review uniquely explores advanced materials used production 3D-printed MNAs, including photopolymer resins, biocompatible materials, composite designed to improve mechanical properties, biocompatibility, functional performance. Additionally, it introduces emerging trends 4D for programmable MNAs. By analyzing recent innovations, this identifies critical challenges proposes future directions advance field Unlike previous reviews, paper emphasizes integration innovative with techniques enhance both performance sustainability

Язык: Английский

Процитировано

2
Zn2SnO4@SiO2@5-FU Nanoparticles as an Additive for Maxillary Bone Defects DOI Open Access

Ana Maria Gianina Rehner,

Ana‐Maria Bratu, Alexandra Cătălina Bîrcă

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 26(1), С. 194 - 194

Опубликована: Дек. 29, 2024

This study investigates the synthesis of Zn2SnO4@SiO2@5-FU nanoparticles as an additive for bone fillers in dental maxillofacial reconstruction. Zn2SnO4 were synthesized and coated with a SiO2 shell, followed by incorporation 5-Fluorouracil (5-FU), aimed at enhancing therapeutic properties classical fillers. Structural analysis using X-ray diffraction confirmed that was single crystalline phase present, its crystallinity preserved after both coating 5-FU incorporation. SEM characterization revealed micro-spherical particles assembled agglomeration nanorods, exhibiting dimensions morphological characteristics consistent addition shell 5-FU. Fourier-transformed infrared spectroscopy provided solid proof successful Zn2SnO4, Zn2SnO4@SiO2, Zn2SnO4@SiO2@5-FU, confirming presence expected functional groups. The layer improved nanoparticle stability solution, indicated zeta potential measurements, while adding significantly increased biocompatibility targeting efficiency. existence is also hydrodynamic diameter, indicating increase particle size incorporating compounds. Antibacterial assays demonstrated selective efficacy against Gram-positive bacteria, showing strongest inhibitory effects. Biofilm inhibition studies further nanoparticles’ effectiveness preventing bacterial colonization. Cytotoxicity tests on A-431 human epidermoid carcinoma cell line dose-dependent reduction viability, highlighting targeted cancer treatment. These findings highlight multifunctional fillers, offering enhanced antimicrobial antitumor capabilities.

Язык: Английский

Процитировано

0