Advances in pathogenesis and therapeutic strategies for osteoporosis

Pharmacology & Therapeutics, Год журнала: 2022, Номер 237, С. 108168 - 108168

Опубликована: Март 10, 2022

Язык: Английский

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The metabolic nature of inflammatory bowel diseases

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2022, Номер 19(12), С. 753 - 767

Опубликована: Июль 29, 2022

Язык: Английский

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Alterations in the Gut Virome in Obesity and Type 2 Diabetes Mellitus

Gastroenterology, Год журнала: 2021, Номер 161(4), С. 1257 - 1269.e13

Опубликована: Июнь 25, 2021

Язык: Английский

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Dysbiosis and Implication of the Gut Microbiota in Diabetic Retinopathy

Frontiers in Cellular and Infection Microbiology, Год журнала: 2021, Номер 11

Опубликована: Март 19, 2021

The pathogenesis of type 2 diabetes mellitus (T2DM) is commonly associated with altered gut bacteria. However, whether the microbial dysbiosis that exists in human diabetic patients or without retinopathy different remains largely unknown. Here, we collected clinical information and fecal samples from 75 participants, including 25 (DM), (DR), healthy controls (HC). composition three groups was analyzed using 16S ribosomal RNA (rRNA) gene sequencing. Microbial structure differed groups. α β diversities both DM DR were reduced compared those HC group. Blautia most abundant genus, especially In addition, increased levels Bifidobacterium Lactobacillus decreased Escherichia-Shigella, Faecalibacterium , Eubacterium_hallii_group Clostridium genera observed Furthermore, a biomarker set bacterial families, which could distinguish group identified, area under curve values ranging 0.69 to 0.85. Of note, Pasteurellaceae HC, generated high AUC (0.74) as an individual predictive biomarker. Moreover, 14 family biomarkers fasting blood glucose diabetes, them being negatively correlated. summary, our study establishes compositional alterations microbiota DR, suggesting potential use non-invasive for differential diagnosis, well identifying therapeutic targets retinopathy.

Язык: Английский

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Allobaculum Involves in the Modulation of Intestinal ANGPTLT4 Expression in Mice Treated by High-Fat Diet

Frontiers in Nutrition, Год журнала: 2021, Номер 8

Опубликована: Май 19, 2021

Increasing studies have shown that obesity is the primary cause of cardiovascular diseases, non-alcoholic fatty liver type 2 diabetes, and a variety cancers. The dysfunction gut microbiota was proved to result in obesity. Recent research indicated ANGPTL4 key regulator lipid metabolism circulating medium for fat deposition. present study conducted investigate alteration expression gastrointestinal tract mice treated by high-fat diet. Ten C57BL/6J were randomly allocated two groups fed with diet (HFD) containing 60% or normal-fat (Control) 10% fat. segments ileum colon collected determination RT-qPCR immunohistochemical analysis while ileal colonic contents 16S rRNA gene sequencing. results showed HFD significantly increased body weight, epididymal perirenal content ( P < 0.05). relative ANGPTL4-positive cells treatment. Furthermore, sequencing suggested treatment changed composition microbiota. ratio Firmicutes Bacteroidetes abundance Allobaculum higher group than Control Adlercreutzia, Bifidobacterium, Prevotellaceae UCG-001 , Ruminococcus decreased. Interestingly, positively correlated ANGPTL4. These findings provide theoretical foundation development strategies control related diseases regulation

Язык: Английский

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Inflammatory Bowel Diseases and Gut Microbiota

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3817 - 3817

Опубликована: Фев. 14, 2023

Inflammatory bowel disease (IBD) is an inflammatory of the gastrointestinal tract, incidence which has rapidly increased worldwide, especially in developing and Western countries. Recent research suggested that genetic factors, environment, microbiota, immune responses are involved pathogenesis; however, underlying causes IBD unclear. Recently, gut microbiota dysbiosis, a decrease abundance diversity specific genera, been as trigger for IBD-initiating events. Improving identifying bacterial species essential understanding pathogenesis treatment autoimmune diseases. Here, we review different aspects role played by provide theoretical basis modulating through probiotics, fecal transplantation, microbial metabolites.

Язык: Английский

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Dysbiotic Gut Bacteria in Obesity: An Overview of the Metabolic Mechanisms and Therapeutic Perspectives of Next-Generation Probiotics

Microorganisms, Год журнала: 2022, Номер 10(2), С. 452 - 452

Опубликована: Фев. 16, 2022

Obesity, a worldwide health concern with constantly rising prevalence, is multifactorial chronic disease associated wide range of physiological disruptions, including energy imbalance, central appetite and food reward dysregulation, hormonal alterations gut dysbiosis. The microbiome well-recognized factor in the pathophysiology obesity, its influence on host physiology has been extensively investigated over last decade. This review highlights mechanisms by which dysbiosis can contribute to obesity. In particular, we discuss microbiota's contribution homeostatic changes, low-grade inflammation, regulation fat deposition bile acid metabolism via bacterial metabolites, such as short-chain fatty acids, components, lipopolysaccharides, among others. Finally, therapeutic strategies based next-generation probiotics aiming re-shape intestinal microbiota reverse metabolic obesity are described.

Язык: Английский

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Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management

World Psychiatry, Год журнала: 2023, Номер 22(3), С. 366 - 387

Опубликована: Сен. 15, 2023

Populations with common physical diseases – such as cardiovascular diseases, cancer and neurodegenerative disorders experience substantially higher rates of major depressive disorder (MDD) than the general population. On other hand, people living MDD have a greater risk for many diseases. This high level comorbidity is associated worse outcomes, reduced adherence to treatment, increased mortality, health care utilization costs. Comorbidity can also result in range clinical challenges, more complicated therapeutic alliance, issues pertaining adaptive behaviors, drug‐drug interactions adverse events induced by medications used mental disorders. Potential explanations prevalence above involve shared genetic biological pathways. These latter include inflammation, gut microbiome, mitochondrial function energy metabolism, hypothalamic‐pituitary‐adrenal axis dysregulation, brain structure function. Furthermore, several antecedents related social factors (e.g., socioeconomic status), lifestyle variables activity, diet, sleep), stressful live childhood trauma). Pharmacotherapies psychotherapies are effective treatments comorbid MDD, introduction interventions well collaborative models digital technologies provide promising strategies improving management. paper aims detailed overview epidemiology specific including bidirectional risk; pathways potentially implicated pathogenesis diseases; socio‐environmental that serve both protective factors; management prevention treatment. We conclude future directions emerging research optimal

Язык: Английский

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Revisiting the role of Akkermansia muciniphila as a therapeutic bacterium

Gut Microbes, Год журнала: 2022, Номер 14(1)

Опубликована: Май 25, 2022

Despite a short history since its first isolation, Akkermansia muciniphila has been extensively studied in relation to effects on human metabolism. A recent intervention study also demonstrated that the bacterium is safe use for therapeutic purposes. The best-known of A. health and disease relate ability strengthen gut integrity, modulate insulin resistance, protect host from metabolic inflammation. further molecular mechanism, induction GLP-1 secretion through ICAM-2 receptor, was recently discovered with identification new bacterial protein produced by muciniphila. However, other studies have suggested detrimental role specific immune settings. Here, we evaluate molecular, mechanistic suggest some missing links be connected before organism should considered as next-generation biotherapeutic agent.

Язык: Английский

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Small Intestinal Bacterial Overgrowth—Pathophysiology and Its Implications for Definition and Management

Gastroenterology, Год журнала: 2022, Номер 163(3), С. 593 - 607

Опубликована: Апрель 7, 2022

Язык: Английский

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