Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 24, 2025
In
recent
years,
tumor
immunotherapy
has
made
significant
breakthroughs
in
the
treatment
of
malignant
tumors.
However,
individual
differences
efficacy
have
been
observed
clinical
practice.
There
is
increasing
evidence
that
gut
microbial
metabolites
influence
distal
via
gut-liver
axis,
gut-brain
axis
and
gut-breast
a
process
may
involve
modulating
expression
immune
cells
cytokines
microenvironment
(TME).
this
review,
we
systematically
explore
relationship
between
immunotherapy,
examine
corresponding
natural
products
their
mechanisms
action.
The
in-depth
exploration
research
area
will
provide
new
ideas
strategies
to
enhance
mitigate
adverse
effects.
World Journal of Gastroenterology,
Год журнала:
2024,
Номер
30(29), С. 3511 - 3533
Опубликована: Июль 28, 2024
(CB),
used
in
traditional
Chinese
medicine,
exhibits
anti-tumor
effects
various
cancer
models.
It
also
constitutes
an
integral
component
of
a
compound
formulation
known
as
Pien
Tze
Huang,
which
is
indicated
for
the
treatment
liver
cancer.
However,
its
impact
on
tumor
microenvironment,
particularly
tumor-associated
macrophages
(TAMs),
not
well
understood.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Май 9, 2024
Colorectal
cancer
(CRC)
is
a
significant
global
health
burden,
with
high
morbidity
and
mortality
rates.
It
often
diagnosed
at
middle
to
advanced
stage,
affecting
approximately
35%
of
patients
the
time
diagnosis.
Currently,
chemotherapy
has
been
used
improve
patient
prognosis
increase
overall
survival.
However,
can
also
have
cytotoxic
effects
lead
adverse
reactions,
such
as
inhibiting
bone
marrow
hematopoiesis,
causing
digestive
dysfunction,
hand-foot
syndrome,
even
life-threatening
conditions.
In
response
these
effects,
researchers
proposed
using
Traditional
Chinese
Medicine
(TCM)
an
option
treat
cancer.
TCM
research
focuses
on
prescriptions,
herbs,
components,
which
form
essential
components
current
in
medicine.
The
study
implementation
prescriptions
herbs
demonstrate
its
distinctive
holistic
approach
therapy,
characterized
by
applying
multi-component
multi-target
treatment.
TMC
advantages
developing
new
drugs
they
consist
single
ingredients,
require
smaller
medication
dosages,
precise
measure
pharmacodynamic
clear
mechanism
action
compared
herbs.
further
still
needed
determine
whether
fully
substitute
therapeutic
efficacy
prescriptions.
This
paper
presents
comprehensive
analysis
advancements
made
components.
findings
this
serve
theoretical
basis
for
who
are
interested
exploring
potential
treatment
colorectal
Pharmacological Research,
Год журнала:
2025,
Номер
213, С. 107636 - 107636
Опубликована: Фев. 1, 2025
FOLFOX
(5-Fluorouracil,
Calcium
Folinate
combined
with
Oxaliplatin)
is
a
preferred
chemotherapy
regimen
for
colon
cancer,
but
its
limited
efficacy
remains
major
challenge,
significantly
impairs
patient
outcomes.
There
an
urgent
need
to
identify
strategies
improve
therapeutic
effectiveness.
Our
previous
studies
have
suggested
that
gut
microbiota-derived
bile
acids
may
be
involved
in
the
anticancer
effect
of
vitro,
however,
underlying
mechanism
unclear.
In
this
study,
we
investigated
role
modulating
and
related
mechanisms.
We
first
demonstrated
depletion
(cholestyramine
treatment)
enhanced
orthotopic
cancer
mouse
model,
suggesting
play
key
FOLFOX's
effects.
Further,
based
on
system
screen
15
via
MTT,
colony
formation
flow
cytometry
assay,
Deoxycholic
Acid
(DCA)
Glycodeoxycholic
(GDCA)
were
annotated
as
potential
modulators
efficacy.
Among
these,
DCA
was
further
validated
enhance
anti-colon
effects
vivo.
Transcriptomic
analysis
subsequent
biological
experiments
revealed
Ugt1a6b.
conclusion,
our
findings
establish
enhances
potentially
Ugt1a6b
mediated
enterohepatic
circulation,
providing
novel
insights
into
synergistic
strategy
improving
treatment.
Abstract
In
the
past
few
years,
emergence
of
organoids
and
organ-on-a-chip
(OOAC)
technologies,
which
are
complementary
to
animal
models
two-dimensional
cell
culture
methods
can
better
simulate
internal
environment
human
body,
provides
a
new
platform
for
traditional
Chinese
medicine
(TCM)
studies.
Organoids
OOAC
techniques
have
been
increasingly
applied
in
fields
drug
screening,
assessment
development,
personalized
therapies,
developmental
biology,
there
some
application
cases
TCM
this
review,
we
summarized
current
status
using
organoid
technologies
research
provide
key
insights
future
study.
It
is
believed
that
will
play
more
important
roles
make
greater
contributions
innovative
development
TCM.
Pharmacological Research,
Год журнала:
2024,
Номер
203, С. 107148 - 107148
Опубликована: Март 22, 2024
The
gut
microbiota,
known
as
the
"forgotten
organ"
and
"human
second
genome,"
comprises
a
complex
microecosystem.
It
significantly
influences
development
of
various
tumors,
including
colorectal,
liver,
stomach,
breast,
lung
cancers,
through
both
direct
indirect
mechanisms.
These
mechanisms
include
"gut-liver"
axis,
"lung-intestine"
interactions
with
immune
system.
intestinal
flora
exhibits
dual
roles
in
cancer,
promoting
suppressing
its
progression.
Traditional
Chinese
medicine
(TCM)
can
alter
cancer
progression
by
regulating
flora.
modifies
flora's
composition
structure,
along
levels
endogenous
metabolites,
thus
affecting
barrier,
system,
overall
body
metabolism.
actions
contribute
to
TCM's
significant
antitumor
effects.
Moreover,
microbiota
metabolizes
TCM
components,
enhancing
their
properties.
Therefore,
exploring
interaction
between
offers
novel
perspective
understanding
This
paper
succinctly
reviews
association
gastric,
cancers.
further
examines
current
research
on
flora,
focus
efficacy.
identifies
limitations
existing
studies
suggests
recommendations,
providing
insights
into
drug
effectiveness.
Additionally,
this
aims
guide
future
studies.
