Celiac Disease: Beyond Diet and Food Awareness

Foods, Год журнала: 2025, Номер 14(3), С. 377 - 377

Опубликована: Янв. 24, 2025

Celiac disease is attributable to a combination of genetic predisposition and exposure dietary gluten, with immune system involvement. The incidence increasing globally, the societal economic burden celiac stretches beyond cost gluten-free food. This enteropathy that affects small intestine has been related different disorders comorbidities. Thus, implications suffering from this are multidimensional need further consideration. serious condition remains under-recognized, resulting in an increased for programs better management. review aims summarize current evidence regarding diseases, special emphasis on clinical implications, diagnosis, management, socioeconomical aspects, future perspectives.

Язык: Английский

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Coeliac disease: complications and comorbidities

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Язык: Английский

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Opportunities for Improving Biopsy and Non–Biopsy-Based Diagnosis of Celiac Disease

Gastroenterology, Год журнала: 2024, Номер 167(1), С. 79 - 89

Опубликована: Янв. 30, 2024

The accumulating data regarding a non-biopsy diagnosis of celiac disease has led to its adoption in certain scenarios, though debate on whether and when use criteria clinical practice remains ongoing.Despite the growing popularity evidence basis for biopsy-free approach context highly elevated serologies, there will nevertheless continue be role biopsy some groups.The present review summarizes current supporting approach, arguments continued reliance biopsy, focuses opportunities improve both approaches.

Язык: Английский

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Celiac Disease, Gluten-Free Diet and Metabolic Dysfunction-Associated Steatotic Liver Disease

Nutrients, Год журнала: 2024, Номер 16(13), С. 2008 - 2008

Опубликована: Июнь 25, 2024

Celiac disease (CD) is a chronic autoimmune disorder triggered by the ingestion of gluten-containing food genetically predisposed individuals. Hence, treatment CD consists permanent avoidance wheat, rye, barley, and other foods. Lifelong adherence to gluten-free diet (GFD) improves symptoms CD, but recent evidence suggests it also associated with higher risk for hepatic steatosis coexistence or emergence cardiometabolic factors. Moreover, liver reported some authors as potential extraintestinal complication itself. Recent nomenclature changes designate association between at least one five factors metabolic dysfunction-associated steatotic (MASLD). An extended network potentially causative underlying MAFLD before after dietary therapy implemented, was recently described. The individualized these patients less supported evidence, most current recommendations relying on empiric clinical judgment. This review focuses associations injury, either an manifestation side effect GFD, referring therapeutic strategies

Язык: Английский

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Controversies and Opportunities of a Nonbiopsy Diagnosis for Celiac Disease

Gastrointestinal Endoscopy Clinics of North America, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Mediterranean Diet Adherence in Celiac Patients: A Nested Cross-Sectional Study

Nutrients, Год журнала: 2025, Номер 17(5), С. 788 - 788

Опубликована: Фев. 25, 2025

Background/Objectives: The Mediterranean diet (MD) reduces cardiovascular risk, which is higher in celiac disease (CD). We aimed to investigate adherence the MD newly diagnosed CD patients, patients on a gluten-free (GFD), and non-celiac control group. Additionally, we establish an association between GFD adherence. Methods: In this nested, cross-sectional Hungarian study, was assessed using Diet Score (MDS), Standardized Dietitian Evaluation (SDE). Results: A total of 215 subjects were enrolled, 128 for minimum 1 year, 24 63 non-CD healthy subjects. Although had mean MDS, groups did not differ statistically significantly from each other (CD GFD: 5.55 ± 1.57, CD: 5.35 1.81, controls: 6.05 1.73; p > 0.05)-all suboptimal scores. Both consumed fewer whole grains than controls (p < 0.001). Adequate associated with MDS (5.62 1.54 vs. 4.71 1.21, respectively; = 0.009). Conclusions: Our study highlights low insufficient consumption grains. Adherence better adherence, underlines role dietary education during follow-up. Targeted nutritional counseling could improve quality reduce risk.

Язык: Английский

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Celiac Disease and Metabolic Diseases: A Review of Emerging Connections

Current Treatment Options in Gastroenterology, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 5, 2025

Язык: Английский

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The Strategies of Picture Books as a Mode of Health Communication for Young Children with Coeliac Disease

Children, Год журнала: 2025, Номер 12(5), С. 530 - 530

Опубликована: Апрель 22, 2025

Background/Objectives: Coeliac disease, a chronic and lifelong health condition, is one of the most common autoimmune diseases. However, it also under-recognised conditions, emotionally cognitively appropriate materials are especially lacking for young children their families who coping with this disease. Effective communication essential educating supporting living coeliac disease as well communities. Picture books can serve useful accessible educational promotion tools, promoting adaptive strategies dealing potentially traumatic condition. Methods: This study aimed to fill critical gap in literature by examining range picture (n = 9) at three eight years age diagnosed Reflective thematic structural narrative analyses were applied explore themes used these how they align current on developing through children’s narratives. Results: Four developed measured against an existing model narratives find more specific that recognises concerns The four found Information Provision; Promotion CD Management; Anxiety Hypervigilance Reduction, two subthemes Validating Feelings Reducing Concerns; Community Connection. Conclusions: findings have likely implications following applications: incorporation into clinician training (as therapeutic intervention), support within schools, authors similar illness, approaches individuals/families promote literacy/support regarding

Язык: Английский

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The Amelioration of Methionine Restriction on the Celiac Toxic Effects of p31–43 Gliadin Peptide Is Disrupted by S‐Adenosyl‐Methionine

Journal of Food Science, Год журнала: 2025, Номер 90(4)

Опубликована: Апрель 1, 2025

ABSTRACT Methionine restriction (MR) has been found to alleviate the progression of diseases such as cognitive disorders and cancer, but it is not clear whether regulating methionine availability can have a beneficial effect on wheat gluten‐induced celiac disease. We aimed excavate effects MR toxic p31–43 gliadin peptide. In this study, we systematically investigated peptide‐induced oxidative damage, elevation tissue transglutaminase enzyme activity, overexpression inflammatory factors, increase permeability, T‐lymphocyte dysfunction by utilizing Caco‐2 epithelial cells lymphocytes derived from mouse mesenteric lymph nodes elucidate effectiveness MR. Moreover, potential mechanism innate adaptive immune regulation was explored with help S ‐adenosyl‐methionine (SAM), critical metabolic intermediate in cycle. discovered that effectively suppressed Furthermore, illustrated controlling role SAM regulate terms both gliadin‐induced responses could directly affect This study might offer novel insights for utilization disease (such interventions or gluten‐free diets specific content) well roles

Язык: Английский

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Impact of tailored dietary interventions on suspected carbohydrate intolerance patients based on genetic testing

Nutrición Hospitalaria, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

carbohydrate intolerance presents a complex scenario where symptoms arise following the consumption of specific substrate and alleviate upon their elimination from diet. Lactose Intolerance is one most prevalent types food intolerance. Primary lactose linked to genetic factors, Lactase Non-Persistence phenotype, while secondary might be temporary condition resulting intestinal damage loss disaccharidase activity. Fructose absorption an energy-independent process, leading limited variable absorption. undergoes quick into bloodstream through active transporters, specifically GLUT-5 GLUT-2, found in initial segment small intestine. The management requires precise testing methods, accurate diagnostics, customized dietary interventions. Genetic plays crucial role determining individual's profile, helping decide whether permanent restrictions on nutrients, such as lactose, are necessary. this research aims understand origin suspected intolerance, combining with breath tests enhance efficacy treatment plans, interventions will based patient's profile capacity. combination (lactase non-persistence celiac disease risk) test for fructose were performed. Recommendations low or gluten-free diets; them provided each results. after nutritional intervention, significant improvement was noted all gastrointestinal symptoms, except reflux nausea, extraintestinal symptoms. designing primary causes can avoid unnecessary restrictions; improving patients' quality life effectiveness tailored

Язык: Английский

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