Global, regional, and national epidemiology of osteoarthritis in working-age individuals: insights from the global burden of disease study 1990–2021 DOI Creative Commons
Weiwei Ma,

Honggu Chen,

Qipeng Yuan

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 6, 2025

Osteoarthritis (OA) is a chronic degenerative joint disease with an increasing global burden, particularly among the working-age population. This study aims to analyze temporal trends in OA burden by age and sex globally from 1990 2021, focusing on incidence, prevalence, disability-adjusted life years (DALYs) rates, predict future trends. Using data Global Burden of Disease (GBD) database, which includes 204 countries regions, we stratified findings sociodemographic index (SDI). Age-standardized rates were used calculate estimated annual percentage change (EAPC) corresponding 95% confidence intervals (95% CI). Additionally, Bayesian Age-Period-Cohort (BAPC) model was employed project up 2040.The results revealed consistent increase over period. Between number cases population increased 16,420,160 35,494,218, representing growth rate 116.16%. Over same period, prevalence DALYs rose 123.11% 125%, respectively. age-standardized incidence (ASIR), (ASPR), (ASDR) exhibited continuous upward trends, changes 0.387%, 0.431%, 0.46%, Notably, East Asia demonstrated highest EAPC, reflecting rapid rise while high-income North America minimal changes, indicating relatively stable trend. Countries such as Equatorial Guinea, Mongolia, Armenia also experienced significant increases underscoring emerging regional challenges.Further socioeconomic analysis highlighted disparities burden. A positive correlation observed between ASIR, ASPR, ASDR, SDI. While low-SDI lower burdens, metrics substantially higher high-SDI countries. From gap lowest SDIs widened, growing health inequalities. Projections based BAPC suggest that 2040, will continue rise, expected reach 38,800,395, driven notable women.These highlight urgent need for developing targeted public strategies mitigate effect promote equity.

Язык: Английский

Global, regional, and national epidemiology of osteoarthritis in working-age individuals: insights from the global burden of disease study 1990–2021 DOI Creative Commons
Weiwei Ma,

Honggu Chen,

Qipeng Yuan

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 6, 2025

Osteoarthritis (OA) is a chronic degenerative joint disease with an increasing global burden, particularly among the working-age population. This study aims to analyze temporal trends in OA burden by age and sex globally from 1990 2021, focusing on incidence, prevalence, disability-adjusted life years (DALYs) rates, predict future trends. Using data Global Burden of Disease (GBD) database, which includes 204 countries regions, we stratified findings sociodemographic index (SDI). Age-standardized rates were used calculate estimated annual percentage change (EAPC) corresponding 95% confidence intervals (95% CI). Additionally, Bayesian Age-Period-Cohort (BAPC) model was employed project up 2040.The results revealed consistent increase over period. Between number cases population increased 16,420,160 35,494,218, representing growth rate 116.16%. Over same period, prevalence DALYs rose 123.11% 125%, respectively. age-standardized incidence (ASIR), (ASPR), (ASDR) exhibited continuous upward trends, changes 0.387%, 0.431%, 0.46%, Notably, East Asia demonstrated highest EAPC, reflecting rapid rise while high-income North America minimal changes, indicating relatively stable trend. Countries such as Equatorial Guinea, Mongolia, Armenia also experienced significant increases underscoring emerging regional challenges.Further socioeconomic analysis highlighted disparities burden. A positive correlation observed between ASIR, ASPR, ASDR, SDI. While low-SDI lower burdens, metrics substantially higher high-SDI countries. From gap lowest SDIs widened, growing health inequalities. Projections based BAPC suggest that 2040, will continue rise, expected reach 38,800,395, driven notable women.These highlight urgent need for developing targeted public strategies mitigate effect promote equity.

Язык: Английский

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