Norepinephrine (NE) promotes activated B cells to identify and kill effector CD8+ T cells through FasL/Fas pathway in spleen mononuclear cells isolated from experimental autoimmune encephalomyelitis (EAE)

Brain Behavior and Immunity, Год журнала: 2025, Номер 125, С. 294 - 307

Опубликована: Янв. 15, 2025

It has been reported that the nervous system can regulate immune reactions through various mechanisms. However, role of splenic sympathetic nerve activity in autoimmune during pathogenesis experimental encephalomyelitis (EAE) remained unclear. Here, we blocked and found number adaptive cells, such as CD4+ T CD8+ cells B were upregulated. Additionally, there was an increase secretion inflammatory cytokines spleen, neurological symptoms EAE exacerbated. In vitro experiments, norepinephrine (NE), neurotransmitter nerve, indirectly drove death effector cells. Furthermore, activated under influence NE, specifically recognized by upregulating MHC-I molecules killed these via FasL/Fas pathway. Our findings provide a new perspective on killing effect vitro, which boosted NE demonstrate controls degree responses EAE. This adds dimension to diversity NE's regulatory effects suggests potential therapeutic approach for diseases.

Язык: Английский

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Clonal hematopoiesis

Seminars in Hematology, Год журнала: 2024, Номер 61(1), С. 1 - 2

Опубликована: Фев. 1, 2024

Язык: Английский

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Targeted Gene Therapy: Promises and Challenges in Disease Management

Journal of Bio-X Research, Год журнала: 2024, Номер 7

Опубликована: Янв. 1, 2024

Targeted gene therapy may revolutionize disease treatment by precisely treating genetic defects. This method targets particular cells or tissues with therapeutic genes to treat a variety of problems, including cancer, hereditary diseases, and viral infections. Viral, nonviral, genome editing techniques such as CRISPR-Cas9 are used for targeted fix modify disease-causing minimal off-target effects. The issues vector immunogenicity, mutations, delivery target persist despite tremendous progress. successful implementation is further hindered illness complexity background diversity. These difficulties require multidisciplinary cooperation, novel design, thorough preclinical clinical assessments. long-term unforeseen effects must also be considered from an ethical viewpoint. has considerable promise, but more research technological advances needed overcome limitations develop safe treatments.

Язык: Английский

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Host Defense Peptides: Exploiting an Innate Immune Component Against Infectious Diseases and Cancer

International Journal of Peptide Research and Therapeutics, Год журнала: 2024, Номер 30(6)

Опубликована: Окт. 5, 2024

Язык: Английский

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