Adoptive transfer of natural killer cells in therapeutic treatment of COVID-19 patients

Egyptian Journal of Medical Human Genetics, Год журнала: 2025, Номер 26(1)

Опубликована: Фев. 22, 2025

Abstract Background Natural killer (NK) cells are crucial constituents of innate immunity, playing a vital role in the early defense against viral infections and cancer. Their antiviral capabilities stem from direct cytotoxic activity infected immunoregulatory functions that modulate adaptive immune responses. In context Coronavirus disease (COVID-19), NK contribute to controlling replication limiting excessive inflammatory Aims This review highlights mechanisms underlying cell-mediated activity, focusing on their interactions with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2). We discuss potential sources for adoptive transfer therapy, critical factors influencing therapeutic efficacy, considerations clinical translation COVID-19 treatment. Methods Various cell therapy discussed, including peripheral blood, cord genetically engineered cells. Key efficacy safety cell-based therapies analyzed, cytokine modulation, subset selection, delivery methods. Conclusion Understanding influence success can inform design more effective immunotherapies patients. Strategies improving function, such as genetic modification optimizing protocols, highlighted enhance outcomes. Graphical neutralize SARS-CoV-2 by releasing granules, inhibiting replication, modulating inflammation. They originate engineering. Therapeutic strategies include transfer, optimized delivery. Inflammation is controlled, reducing

Язык: Английский

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CAR T-cell therapy comes of age: Introductory editorial for the special issue

Seminars in Hematology, Год журнала: 2024, Номер 61(5), С. 271 - 272

Опубликована: Окт. 1, 2024

Язык: Английский

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