Direct remote Csp²–H transformation of aromatic amines enabled by organophotoredox catalysis

Green Chemistry, Год журнала: 2024, Номер 26(12), С. 7007 - 7012

Опубликована: Янв. 1, 2024

An organophotoredox-catalyzed difluoromethylation of aromatic amines was developed for green, environmentally friendly, sustainable, and expedient access to high value-added para -difluoromethylated compounds with excellent regioselectivities.

Язык: Английский

Iron-catalyzed non-directed arene C-H difluoromethylation

Green Synthesis and Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Авг. 1, 2024

Practical, undirected and selective catalytic functionalization of unactivated arenes remains a challenging problem in organic synthesis. We herein report bioinspired L-cystine-derived ligand BCPOM/Fe-enabled innate C-H difluoromethylation as limiting reagents with stable inexpensive BrCF2CO2Et the source high efficiency. Notably, this method uses environmentally benign H2O2 sole oxidant, enables late-stage exceptionally functional-group tolerance, even including oxidation-labile aldehyde, phenolic hydroxy, primary amine, boronic acid groups, which is difficult to access by current means.

Язык: Английский

Rhodium(III)-Catalyzed Synthesis of Quinazolin-4(3H)-ones with N-Methoxyamides as Synthesis Reagents

Synthesis, Год журнала: 2022, Номер 54(14), С. 3298 - 3306

Опубликована: Март 9, 2022

Abstract A practical method to synthesize quinoxalinones via intra/intermolecular amination using rhodium as the catalyst was developed. wide variety of were prepared from N-methoxybenzamides in moderate excellent yields. Gram-scale reactions also achieved, highlighting synthetic importance this new transformation.

Язык: Английский