Decarboxylative Alkenylation of Imidazo[1,2-a]pyridines Using α,β-Unsaturated Carboxylic Acids via Pd-Catalyzed C–H Functionalization

Synthesis, Год журнала: 2023, Номер 55(21), С. 3575 - 3581

Опубликована: Март 31, 2023

Abstract An efficient synthesis of alkenylated imidazo[1,2-a]pyridines has been accomplished using and α,β-unsaturated carboxylic acids adopting C–H functionalization strategy in the presence palladium acetate, 1,10-phenanthroline, silver carbonate.

Язык: Английский

Free Amine-Directed Redox Neutral Ruthenium(II) Catalysis toward Regioselective Synthesis of Heterobiaryls

Organic Letters, Год журнала: 2024, Номер 26(15), С. 2987 - 2992

Опубликована: Апрель 2, 2024

A regioselective coupling of ortho-heteroaryl anilines and 7-oxabenzonorbornadienes has been developed by leveraging free amine-directed redox-neutral Ru(II) catalysis. This protocol facilitates formal C-2 arylation the indole moiety under mild conditions to offer valuable heterobiaryls in high yields. The reaction displays a broad substrate generality scalability retains efficacy presence diverse pharmacophore scaffolds. Moreover, products bearing amine group were successfully employed Mg(NTf2)2-catalyzed double Michael addition cascade, which led synthesis intricate indole- pyrrole-fused azaheterocycles.

Язык: Английский

Rh-catalysed enantioselective [2+2+1] cycloaddition reactions using three different 2π-components

Nature Synthesis, Год журнала: 2024, Номер 3(11), С. 1414 - 1426

Опубликована: Июль 17, 2024

Язык: Английский