Angewandte Chemie,
Год журнала:
2023,
Номер
136(1)
Опубликована: Ноя. 16, 2023
Abstract
The
concept
of
a
domino‐type
reaction
has
been
applied
in
wide
range
fields
such
as
synthetic
organic
chemistry,
material
engineering,
and
life
science.
To
extend
the
domino
to
redox
we
designed
synthesized
dimeric
quinodimethane
(QD)
with
nonplanar
dithiin
spacer.
domino‐redox
properties
can
be
activated
by
raising
temperature,
based
on
thermally
equilibrated
twisted
conformation
QD,
which
higher
HOMO
level
that
is
more
readily
oxidized.
After
one
QD
unit
oxidized
(trigger),
steric
repulsion
electronic
interaction
between
electrophores
make
neighboring
adopt
(domino
process),
facilitates
following
oxidation.
Thus,
was
achieved
for
first
time
change
due
drastic
molecular
conformation.
Molecules,
Год журнала:
2024,
Номер
29(11), С. 2481 - 2481
Опубликована: Май 24, 2024
Quinone
imines
are
important
derivatives
of
quinones
with
a
wide
range
applications
in
organic
synthesis
and
the
pharmaceutical
industry.
The
attack
nucleophilic
reagents
on
quinone
tends
to
lead
aromatization
skeleton,
resulting
both
high
reactivity
unique
imines.
extreme
value
construction
nitrogen-
or
oxygen-containing
heterocycles
has
attracted
widespread
attention,
remarkable
advances
have
been
reported
recently.
This
review
provides
an
overview
application
cyclic
compounds
via
domino
annulation
reaction.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(21), С. 15607 - 15622
Опубликована: Окт. 17, 2024
While
bicyclic
isothiourea
(ITU)
moieties
are
found
in
biologically
active
molecules
and
organocatalysts,
a
catalytic
asymmetric
synthesis
of
ITUs
is
pending.
Here,
we
report
the
catalytic,
enantioselective
functionalization
enolizable
template
European Journal of Organic Chemistry,
Год журнала:
2023,
Номер
26(9)
Опубликована: Янв. 25, 2023
Abstract
1‐Azaspirocycles
are
important
structures
present
in
many
drugs
and
natural
products.
This
work
describes
the
silver‐catalyzed
tandem
cyclization
strategy,
which
provides
atom‐economical
access
to
various
azaoxa‐
diazaspirocycles
from
alkynes
containing
two
appended
oxygen‐
nitrogen‐based
nucleophiles.
Intramolecular
attack
of
pendant
nucleophile
on
situ‐generated
iminium
intermediate
is
key
success
this
transformation.
Current Organic Chemistry,
Год журнала:
2023,
Номер
27(2), С. 71 - 92
Опубликована: Янв. 1, 2023
Abstract:
This
review
updates
the
field
of
asymmetric
cascade
palladium
catalysis
applied
to
synthesis
chiral
heterocycles
since
2019.
It
illustrates
how
much
a
diversity
catalysts
promote
unprecedented
domino
reactions
many
types,
allowing
direct
access
wide
variety
complex
and
densely
functionalized
heterocyclic
molecules.
Angewandte Chemie,
Год журнала:
2023,
Номер
136(1)
Опубликована: Ноя. 16, 2023
Abstract
The
concept
of
a
domino‐type
reaction
has
been
applied
in
wide
range
fields
such
as
synthetic
organic
chemistry,
material
engineering,
and
life
science.
To
extend
the
domino
to
redox
we
designed
synthesized
dimeric
quinodimethane
(QD)
with
nonplanar
dithiin
spacer.
domino‐redox
properties
can
be
activated
by
raising
temperature,
based
on
thermally
equilibrated
twisted
conformation
QD,
which
higher
HOMO
level
that
is
more
readily
oxidized.
After
one
QD
unit
oxidized
(trigger),
steric
repulsion
electronic
interaction
between
electrophores
make
neighboring
adopt
(domino
process),
facilitates
following
oxidation.
Thus,
was
achieved
for
first
time
change
due
drastic
molecular
conformation.
