One-pot multistep synthesis of 1-fluoroalkylisoquinolines and fused fluoroalkylpyridines from N-fluoroalkyl-1,2,3-triazoles
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(16), С. 4442 - 4448
Опубликована: Янв. 1, 2024
Microwave
heating
of
N
-fluoroalkyl-1,2,3-triazoles
proceeding
via
ketenimines
and
difluoroazadienes
provided
1-fluoroalkyl-3-fluoroisoquinolines.
Язык: Английский
Metal-Free Synthesis of 2-(per)Fluoroalkyl-3-nitro Indoles via Intramolecular Cyclization of Amides
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 12, 2024
A
metal-free
intramolecular
cyclization
of
N-acyl
amides
for
the
synthesis
3-nitro-2-(per)fluoroalkyl
indoles
is
reported.
Good
functional
group
tolerance
and
a
broad
range
substrates
are
features
this
approach.
The
developed
method
easy
to
operate
suitable
preparation
2-difluoromethyl/trifluoromethyl/perfluoroethyl/perfluoropropyl
in
yields
84
99%.
Also,
application
protocol
gram
scale
shown.
Язык: Английский
Attempts on Fluorinative Transformation of Selected Functionalized Cycloalkene Scaffolds through Aziridination/Aziridine-Opening Protocol
Synlett,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 24, 2024
Abstract
Studies
on
the
transformations
of
some
functionalized
cycloalkene
derivatives
through
their
ring
olefin-bond
aziridination/aziridine
opening
with
fluoride
are
presented.
The
selected
model
compounds
submitted
to
fluorinative
functionalization
were
an
amino
ester
and
diesters
a
cyclohexene
skeleton
as
well
cyclopentene-fused
β-lactam.
Functionalization
proceeded
across
substrate-directed
diastereoselective
aziridination,
followed
by
fluoride-mediated
aziridine
or
intramolecular
lactonization
giving
fluorinated
lactone
derivatives.
Язык: Английский