Visible-Light-Induced Tandem Reaction of Quinoxalin-2(1H)-ones, Alkenes, and Sulfonyl Chlorides

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(33), С. 6799 - 6809

Опубликована: Янв. 1, 2024

A visible-light-induced tandem reaction involving quinoxalin-2(1

Язык: Английский

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Recent Advances in Visible‐Light‐Enabled C3‐H Fluoroalkylation of Quinoxalin‐2(1H)‐ones

ChemistrySelect, Год журнала: 2025, Номер 10(12)

Опубликована: Март 1, 2025

Abstract In light of the extensive application fluoroalkyl‐containing molecules and functionalized quinoxalin‐2(1 H )‐ones in medicinal chemistry functional materials, visible‐light‐enabled C3‐H fluoroalkylation has garnered significant attention. this review, we provide a detailed overview latest advancements rapidly evolving research area. We cover utilization various fluoroalkyl sources under conditions photocatalyst or without photocatalyst, discuss pertinent reaction conditions, mechanisms, substrate scope. Our objective is to help more chemists comprehend challenges opportunities within field, thereby fostering its development.

Язык: Английский

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Advances in Direct Fluoroalkylation of Organic Substrates with Partially Fluorinated Alkyl Motivs

ACS Catalysis, Год журнала: 2024, Номер 14(21), С. 15879 - 15907

Опубликована: Окт. 11, 2024

Partially fluorinated alkyl groups other than methyl are increasingly playing crucial roles in the development of drugs with diverse biological activities, thus creating an innovative chemical space within organofluorine chemistry. For studies structure–activity relationships, late-stage modification such or substituents into substrates that bear activity is essential. This perspective will study catalytic protocols for direct introduction partially monofluoroalkylated (−CHFR, –CH2CH2F), difluoroalkylated (−CF2Me, –CH2CF2H), trifluoroalkylated (−CHR(CF3), –CH2CF3, –CH2CH2CF3, –CH(Me)CF3, –C(Me)2CF3), and pentafluoropropylated (−CH2C2F5) onto (hetero)aromatic compounds, double bonds, isonitriles, halides, N, O, S atoms.

Язык: Английский

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Photochemical alkylation of quinoxalin-2(1H)-ones with N,N,N′,N′-tetraalkylethylenediamine

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

A visible-light-induced C-3 alkylation of quinoxalin-2(1 H )-ones with N , ′, ′-tetraalkylethylenediamine was achieved without an external photocatalyst.

Язык: Английский

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Photochemical direct C3 cyanoalkylation of quinoxalin-2(1H)-ones with cyclobutanone oxime esters under catalyst-free conditions

Tetrahedron Letters, Год журнала: 2024, Номер 153, С. 155363 - 155363

Опубликована: Ноя. 12, 2024

Язык: Английский

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