One pot conversion of phenols and anilines to aldehydes and ketones exploiting α gem boryl carbanions

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Май 7, 2024

Abstract Functional group interconversion is an important asset in organic synthesis. Phenols/anilines being naturally abundant and the carbonyl most common a wide range of bioactive molecules, efficient conversion prime interest. The reported methods require transition metal catalyzed cross coupling which limits its applicability. Here we have described method for synthesizing various aldehydes ketones, starting from phenol protected anilines via Csp 2 -O/N bond cleavage one-pot/stepwise manner. Our synthetic found to be compatible with diverse phenols carrying sensitive functional groups including halides, esters, ketal, hydroxyl, alkenes, terminal alkynes as well substitution on aryl cores. A short-step synthesis molecules their functionalization been executed. Starting BINOL, photocatalyst has designed. Here, developed metal-free protocol ketones.

Язык: Английский

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Regioselective Synthesis of α-Vinyl Boronates via a Pd-Catalyzed Mizoroki–Heck Reaction

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Авг. 30, 2024

We report a palladium-catalyzed synthesis of α-vinyl boronates via regioselective Mizoroki-Heck reaction between aryl triflates and vinyl boronates. This selectivity is achieved by the use 1,5-diaza-3,7-diphosphacyclooctane (P

Язык: Английский

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Pd/Charcoal Catalyzed Reduction of Vinyl Geminal Diboronates

Synfacts, Год журнала: 2023, Номер 19(10), С. 0988 - 0988

Опубликована: Сен. 14, 2023

Key words palladium catalysis - gem-diborylalkanes hydrogenation

Язык: Английский

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