Опубликована: Май 29, 2024
The development of efficient and sustainable synthetic processes for pharmaceuticals is a critical area research, primarily driven by the pharmaceutical industry. However, fostering such research in academic institutions holds immense potential. SYNTHESIS special issue on "Synthetic Development Key Intermediates Active Pharmaceutical Ingredients (APIs)" highlighted recent advancements this field. In Thieme Cheminar chaired Prof. Laha (Guest Editor “Synthetic (APIs)” collection) our speakers will share discuss their results Chair: * Joydev Kumar (National Institute Education Research, India) Our speakers: Dr. Luca Laraia (Technical University Denmark): Next-generation strategies synthesis functional, natural product inspired compounds. Sharada Prasanna Swain Research): Photocatalyzed Continuous-flow Pharmaceuticals. Gangarajula Sudhakar (CSIR- Indian Chemical Technology): role steps order developing key intermediates active ingredients. Nilanjana Majumdar (CSIR-Central Drug Research Institute): Unactivated Carboxylic Acids Catalytic Asymmetric Ring Opening Reactions. compounds Natural products derivatives have been source bioactive therapeutics centuries; however, isolation feasibility challenges hamper use. Chemists sought to address rapidly access larger numbers product-inspired compounds, including diversity- biology-oriented (DOS BIOS), complexity-to-diversity (CtD) pseudo-natural (PNPs). lecture I highlight group’s work combining all above specific biological challenges, selective inhibitors sterol transport proteins (STPs) G-protein coupled receptors (GPCRs), as well new photochemical methods diverse scaffolds from cheap, abundant products. Reactions acids are considered feedstock chemicals they widely available, highly stable inexpensive. They can be excellent choice substrates catalytic asymmetric reactions but quite challenging well. Free carboxylic generally not compatible various transformations, e.g. difficult nucleophilic or electrophilic reactions. Here, convenient use free acid illustrated ring opening preparation important class that may act useful chiral synthons. ingredients tailored target requirements often differs significantly between process chemistry. chemistry, emphasis typically using known, reliable, readily available raw materials ensure commercial viability, rather than employing complex specialized reagents. A consistent focus large-scale manufacturing involves avoiding costly hazardous reagents reaction conditions, enhancing yields, reducing waste generation. some instances, minor modifications yield significant benefits, improved environmental impact, cost reduction, more materials, increased energy efficiency step economy. line with these objectives, has led novel route an advanced intermediate Ledipasvir. This late-stage cyclopropanation fluorination. Additionally, we devised telescopic Gliflozin Aglycone, which includes ortho-lithiation 1,4-dihalobenzene followed corresponding aldehydes subsequent reduction resulting diaryl methanol intermediate. These innovative laboratory-scale syntheses currently being evaluated potential scale-up processes, reflecting commitment optimizing through strategic, incremental improvements. Pharmaceuticals Flow chemistry helps safe handling reagents, high temp. reactions, scalable photocatalyzed Boron containing building blocks Suzuki coupling drug molecules Tavaborole, (antifungal), Crisaborole Bortezomib (anticancer) etc. metal-free method boron developed flow reactor. suitable Crisbrooke other
Язык: Английский
