Research Progress in the Synthesis of Azaindoline and Its Derivatives DOI Open Access
Hao Ye,

Haibin Zhang,

Yanan Wu

и другие.

Chinese Journal of Organic Chemistry, Год журнала: 2024, Номер 44(4), С. 1106 - 1106

Опубликована: Янв. 1, 2024

The azaindoline skeleton exists in a wide range of bioactive molecules and natural products, has significant biological pharmaceutical activities.The synthesis these compounds attracted great attention from chemists.However, due to the electron-deficient nature pyridine ring where nitrogen atom is located, many traditional methods for indoline cannot effectively construct skeleton.In recent years, chemists have been exploring made some progress.According different reaction types, azaindolines years key mechanisms are reviewed discussed, future development prospect this research field prospected.

Язык: Английский

Synthesis of Unsymmetrical 3,3′-Dialkyloxindole Boronic Esters from 3-Alkylidene-2-oxindoles Enabled by Copper Catalysis DOI
Pinku Prasad Mondal,

Alvin Antony Chungath,

Malavika Krishnan

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(14), С. 10403 - 10408

Опубликована: Июль 6, 2024

We describe a 1,2-alkylboration of 3-alkylidene-2-oxindoles with diboron reagent and alkyl bromides iodides enabled by copper/bisphosphine catalysis. This scalable alkylboration method provides facile access to 3,3'-dialkyloxindole boronic esters featuring an all-carbon quaternary stereocenter increased F(sp

Язык: Английский

Процитировано

0
Research Progress in the Synthesis of Azaindoline and Its Derivatives DOI Open Access
Hao Ye,

Haibin Zhang,

Yanan Wu

и другие.

Chinese Journal of Organic Chemistry, Год журнала: 2024, Номер 44(4), С. 1106 - 1106

Опубликована: Янв. 1, 2024

The azaindoline skeleton exists in a wide range of bioactive molecules and natural products, has significant biological pharmaceutical activities.The synthesis these compounds attracted great attention from chemists.However, due to the electron-deficient nature pyridine ring where nitrogen atom is located, many traditional methods for indoline cannot effectively construct skeleton.In recent years, chemists have been exploring made some progress.According different reaction types, azaindolines years key mechanisms are reviewed discussed, future development prospect this research field prospected.

Язык: Английский

Процитировано

0