Biomedical Journal, Год журнала: 2024, Номер unknown, С. 100804 - 100804
Опубликована: Окт. 1, 2024
Язык: Английский
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Март 21, 2025
Background The mechanisms underlying persistent symptoms after non-severe COVID-19 remain unclear. This study aimed to investigate transcriptomic changes in peripheral blood cells of patients with post-COVID-19 condition (PCC) and assess if distinct clinical subtypes specific gene signatures could be identified. Methods cohort included 111 PCC from the SARS-CoV-2 Omicron variant era, 57 recovered (Recov) 54 having prolonged indicative PCC. results were compared 63 healthy controls (Ctrl) without known infection. Clinical data patient assessments, laboratory results, comorbidities, questionnaires on quality life functioning. Transcriptomic analysis cellular deconvolution methods used total RNA mononuclear (PBMCs). Results had more comorbidities (mean 1.3) frequently (59%) at least one comorbidity than (31%) (24%). Overall, past illness or current caused minimal cell transcriptome, only 3–6 differentially expressed genes (DEGs) identified across comparisons. However, a subset male exhibited an increased fraction deconvoluted erythroblasts significant genome-wide expression changes, 399 DEGs control males. These enriched pathways related heme metabolism gas exchange erythrocytes. Conclusions Persistent are multifactorial not directly linked changes. subgroup shows erythrocyte responses that may contribute long-term symptoms.
Язык: Английский
Процитировано
0
Frontiers in Public Health, Год журнала: 2024, Номер 12
Опубликована: Март 15, 2024
Background The persistence of symptoms or the development new following a diagnosis SARS-CoV-2 has given rise to multifaceted clinical condition referred as “long COVID” (LC). understanding LC among China’s non-hospitalized population continues be insufficient. This investigation was designed evaluate protracted consequences amongst this demographic, well identify associated risk factors. Methods research constitutes prospective cohort study focusing on individuals, aged between 18 and 59, who have been positively diagnosed with COVID-19. Each participant subjected sequence questionnaire-based surveys, status depression anxiety. A logistic regression model, adjusted for multiple variables, employed scrutinize correlation demographic elements, lifestyle attributes, health-related factors in relation conditions post COVID-19 infection. Results total 706 individuals participated 3 months follow-up, 620 continuing 6 follow-up. median age 35 (28, 43) years, 597 (85%) are female. Upon Compared patients without LC, higher proportion females (420 (87%) vs. 177 (79%); p = 0.010), were older (35 (29, 44) years 33 (27, 41) years; 0.010) more comorbidities. Out all participants, 483 (68.4%) reported experiencing at least one symptom mark, while 49.7% persisting mark. At most prevalent persistent cough (46%), fatigue (38%), shortness breath (34%). By (25%), (22%), sleep disorders (16%) commonly symptoms. Anxiety consistently throughout follow-up period. Most patient fade over time, quickest decreases observed (from 46 9%), expectoration 26 6.3%), smell disorder 16 3.9%), taste 3.5%). Male those possessing advanced educational qualifications exhibit decreased susceptibility sustained incidence coughing. Conversely, presence comorbidities identified breath. Conclusion In after COVID-19, it that majority tend decrease time. primary residual noticed month fatigue, dyspnea, disturbances. However, it’s noteworthy these subtle variations. Furthermore, psychological sequelae, namely anxiety, frequently survivors.
Язык: Английский
Процитировано
2
Brain medicine :, Год журнала: 2024, Номер unknown, С. 1 - 7
Опубликована: Авг. 30, 2024
Long-term complications, such as extensive fatigue and cognitive issues, are known from various infections, including SARS-CoV-2, influenza virus, or Borrelia burgdorferi . The pathology is mostly unknown differs between patients. Unfortunately, there currently no common effective treatment. In this perspective, we imply that post-acute infectious syndromes due to a variety of factors, among others diminished tissue perfusion, infiltration by viruses, inflammation, oxidative stress, not one specific biomarker can be used measure these syndromes. Thus, suggest score based on number criteria/factors should assess Consequently, probably single treatment treat group patients, multimodal regimen comprising combination pharmacotherapy, metformin naltrexone with anti-inflammatory effects, alongside physical therapies extracorporeal apheresis transcutaneous neurotherapy. This combined approach aims reduce levels enhance functions. implies reset the systems achieved for
Язык: Английский
Процитировано
2
Hormone and Metabolic Research, Год журнала: 2024, Номер 56(04), С. 259 - 260
Опубликована: Апрель 1, 2024
Dear Readers, Currently, there is a myriad of new developments in the field endocrinology. In particular, significant strides have been made development poly-agonists for treatment type 2 diabetes and obesity 1 2. Poly-agonists represent novel therapeutic approach by combining multiple actions within single molecule, targeting receptors simultaneously to achieve enhanced efficacy. These innovative compounds aim address complex interplay hormonal pathways involved glucose regulation metabolism, offering potential breakthroughs management obesity.
Язык: Английский
Процитировано
0
Biology, Год журнала: 2024, Номер 13(11), С. 948 - 948
Опубликована: Ноя. 19, 2024
SARS-CoV-2 infection adversely affects rheological parameters, particularly red blood cell (RBC) aggregation and deformability, but whether these changes persist in patients suffering from Long-COVID (LC) are related to RBC morphology remain unknown.
Язык: Английский
Процитировано
0
Biomedical Journal, Год журнала: 2024, Номер unknown, С. 100804 - 100804
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0