ACS Omega, Год журнала: 2024, Номер 9(47), С. 47105 - 47113

Опубликована: Ноя. 15, 2024

Aromatic azo compounds stand as a highly sought-after class of substances owing to their extensive array applications across various fields. Despite significance, synthesis often presents challenges, requiring either multistep reactions or being restricted specific substrate types. In this study, we are showing the universality and mechanistic aspects one-step approach for nonsymmetrical azoarenes via Buchwald–Hartwig amination reaction (pseudo)haloaromatics with arylhydrazines, conducted in presence atmospheric oxygen. This protocol yields products up 85% yield is compatible wide substituents, making it adaptable. Notably, inclusion BINAP ligand plays pivotal role achieving favorable outcomes. study not only offers versatile solution long-standing synthetic challenge but also provides experimental computational insights into mechanisms driving reaction.

Язык: Английский