Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD) Impacts Long‐Term Outcomes After Curative‐Intent Surgery for Hepatocellular Carcinoma
Alimentary Pharmacology & Therapeutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 18, 2025
ABSTRACT
Background
Curative
surgery
for
hepatocellular
carcinoma
(HCC)
includes
liver
resection
(LR)
and
orthotopic
transplantation
(OLT).
Due
to
the
obesity
epidemic,
metabolic
dysfunction‐associated
steatotic
disease
(MASLD)
is
a
frequent
HCC
aetiology
that
often
coincides
with
increased
alcohol
consumption,
termed
MetALD,
or
even
alcohol‐associated
(ALD).
Methods
Patients
undergoing
LR
OLT
at
Charité—Universitätsmedizin
Berlin
(2010–2020)
were
included
in
this
retrospective
cohort
study
investigating
aetiology,
time
recurrence
(TTR),
overall
survival
(OS)
CT‐based
body
composition.
Results
Out
of
579
patients
HCC,
417
underwent
162
OLT.
Tumour
aetiologies
viral
n
=
191
(33.0%),
MASLD
158
(27.3%),
MetALD
51
(8.8%),
ALD
68
(11.7%)
other/cryptogenic
111
(19.2%).
had
more
intramuscular
(
p
<
0.001,
0.015)
visceral
fat
(both
0.001)
than
non‐metabolic
dysfunction
aetiologies.
MASLD‐HCC
comparable
TTR
(median
26
months,
[95%
CI:
23–31]
vs.
30
months
4–57],
0.425)
but
shorter
OS
other
(63
42–84]
80
60–100],
hazard
ratio:
1.53
1.050–2.229],
0.026)
after
LR.
Multivariate
analysis
confirmed
portal
vein
thrombosis
MELD
score
≥
10
as
independent
prognostic
factors
(adjusted
0.021,
0.003),
excluding
in‐hospital
mortality
0.016,
0.002,
0.002).
Causes
death
similar
non‐MASLD
aetiology.
Conclusions
meeting
new
criteria
have
significantly
OS.
This
provides
empirical
evidence
novel
MASLD/MetALD
classification
large
European
curative‐intent
therapy.
Язык: Английский
Spatial‒temporal heterogeneities of liver cancer and the discovery of the invasive zone
Clinical and Translational Medicine,
Год журнала:
2025,
Номер
15(2)
Опубликована: Фев. 1, 2025
Solid
tumours
are
intricate
and
highly
heterogeneous
ecosystems,
which
grow
in
invade
normal
organs.
Their
progression
is
mediated
by
cancer
cells'
interaction
with
different
cell
types,
such
as
immune
cells,
stromal
cells
endothelial
the
extracellular
matrix.
Owing
to
its
high
incidence,
aggressive
growth
resistance
local
systemic
treatments,
liver
has
particularly
mortality
rates
worldwide.
In
recent
decades,
spatial
heterogeneity
garnered
significant
attention
an
unfavourable
biological
characteristic
of
tumour
microenvironment,
prompting
extensive
research
into
role
development.
Advances
omics
have
facilitated
detailed
analysis
states
cell‒cell
interactions,
allowing
a
thorough
understanding
temporal
heterogeneities
microenvironment
informing
development
novel
therapeutic
approaches.
This
review
illustrates
latest
discovery
invasive
zone,
systematically
introduced
specific
macroscopic
heterogeneities,
pathological
cancer.
Язык: Английский
Hepatic arterial infusion of GEMOX plus systemic gemcitabine chemotherapy combined with lenvatinib and PD-1 inhibitor in large unresectable intrahepatic cholangiocarcinoma
International Immunopharmacology,
Год журнала:
2024,
Номер
140, С. 112872 - 112872
Опубликована: Авг. 8, 2024
Язык: Английский
Letter: Comparing the Efficacy of Adjuvant PD–1 Inhibitor After Curative Resection for Metabolic Dysfunction‐Associated Steatotic Liver Disease Related HCC Versus Other Aetiologies—Authors' Reply
Alimentary Pharmacology & Therapeutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 4, 2025
Язык: Английский
Tumor-Associated Macrophages: Polarization, Immunoregulation, and Immunotherapy
Cells,
Год журнала:
2025,
Номер
14(10), С. 741 - 741
Опубликована: Май 19, 2025
Tumor-associated
macrophages’
(TAMs)
origin,
polarization,
and
dynamic
interaction
in
the
tumor
microenvironment
(TME)
influence
cancer
development.
They
are
essential
for
homeostasis,
monitoring,
immune
protection.
Cells
from
bone
marrow
or
embryonic
progenitors
dynamically
polarize
into
pro-
anti-tumor
M2
M1
phenotypes
based
on
cytokines
metabolic
signals.
Recent
advances
TAM
heterogeneity,
characterization,
immunological
responses,
therapy
described
here.
The
manuscript
details
functions
their
role
resistance
to
PD-1/PD-L1
blockade.
Similarly,
TAM-targeted
approaches,
such
as
CSF-1R
inhibition
PI3Kγ-driven
reprogramming,
discussed
address
immunity
suppression.
Furthermore,
innovative
biomarkers
combination
may
enhance
TAM-centric
therapies.
It
also
stresses
relevance
of
this
distinct
cell
human
health
disease,
which
could
impact
future
research
Язык: Английский
Chronic Inflammation and Immune Dysregulation in Metabolic-Dysfunction-Associated Steatotic Liver Disease Progression: From Steatosis to Hepatocellular Carcinoma
Biomedicines,
Год журнала:
2025,
Номер
13(5), С. 1260 - 1260
Опубликована: Май 21, 2025
Background/Objectives:
Metabolic-dysfunction-associated
steatotic
liver
disease
(MASLD)
progresses
from
hepatic
steatosis
to
hepatocellular
carcinoma
(HCC)
as
a
result
of
systemic
immunometabolic
dysfunction.
This
review
summarizes
the
key
roles
innate
and
adaptive
immune
mechanisms
driving
injury,
fibrogenesis,
carcinogenesis
in
MASLD.
Methods:
A
comprehensive
literature
was
performed
using
PubMed
identify
relevant
published
studies.
Eligible
articles
included
original
research
clinical
studies
addressing
immunological
metabolic
MASLD,
well
emerging
therapeutic
strategies.
Results:
We
highlight
cytokine
networks,
gut–liver
axis,
cell
reprogramming.
Emerging
strategies,
including
inhibitors,
anti-fibrotic
agents,
modulators,
nutraceuticals,
offer
several
indications
for
attenuating
MASLD
progression
reducing
prevalence
extrahepatic
manifestations.
Conclusions:
Given
heterogeneity
personalized
combination-based
approaches
targeting
both
inflammation
stress
are
essential
effective
management
prevention
complications.
Язык: Английский