Improving the Photochemical Skeletal Enlargement of Pyridines to 1,2‐Diazepines with Isocyanates DOI
Clément Ghiazza,

Aurélie Damond,

Jérôme Marrot

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Окт. 31, 2024

Abstract In this work, we extend the one‐pot protocol to synthesize 1,2‐diazepines from commercially available and cheap starting materials. Capitalizing on isocyanate derivatives as activating agents, photochemical skeletal enlargement occurs, while preserving key functional groups embedded in more than 30 substrates. We also demonstrated that isocyanates can be generated situ exploiting wealth of methods bench stable resources. Compare previous strategies, use these precursors prevents presence deleterious HCl traces system, thus enabling synthesis high yields over up 5 sequential steps.

Язык: Английский

Improving the Photochemical Skeletal Enlargement of Pyridines to 1,2‐Diazepines with Isocyanates DOI
Clément Ghiazza,

Aurélie Damond,

Jérôme Marrot

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Окт. 31, 2024

Abstract In this work, we extend the one‐pot protocol to synthesize 1,2‐diazepines from commercially available and cheap starting materials. Capitalizing on isocyanate derivatives as activating agents, photochemical skeletal enlargement occurs, while preserving key functional groups embedded in more than 30 substrates. We also demonstrated that isocyanates can be generated situ exploiting wealth of methods bench stable resources. Compare previous strategies, use these precursors prevents presence deleterious HCl traces system, thus enabling synthesis high yields over up 5 sequential steps.

Язык: Английский

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