Silver-Catalyzed Formal [3 + 3] Heteroannulation of Aziridines with 3-Aminoacrylates via Ring-Opening and C–H Amination: Access to 1,4,5,6-Tetrahydropyrazines DOI
Mingzhu Zhang,

Liang Zeng,

Ming Hu

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Direct construction of the piperazine scaffolds with multiple functionalities remains important yet challenging. Herein, a silver-catalyzed formal [3 + 3] heteroannulation aziridines 3-aminoacrylates via ring-opening and vinyl C(sp2)-H amination for direct synthesis tetrasubstituted 1,4,5,6-tetrahydropyrazines is reported. Upon catalytic activation silver Lewis acid, this protocol enables formation two new C-N bonds through selective nucleophilic C-H aminative cyclization cascades, featuring broad substrate scope good functional group tolerance excellent selectivity.

Язык: Английский

Silver-Catalyzed Formal [3 + 3] Heteroannulation of Aziridines with 3-Aminoacrylates via Ring-Opening and C–H Amination: Access to 1,4,5,6-Tetrahydropyrazines DOI
Mingzhu Zhang,

Liang Zeng,

Ming Hu

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Direct construction of the piperazine scaffolds with multiple functionalities remains important yet challenging. Herein, a silver-catalyzed formal [3 + 3] heteroannulation aziridines 3-aminoacrylates via ring-opening and vinyl C(sp2)-H amination for direct synthesis tetrasubstituted 1,4,5,6-tetrahydropyrazines is reported. Upon catalytic activation silver Lewis acid, this protocol enables formation two new C-N bonds through selective nucleophilic C-H aminative cyclization cascades, featuring broad substrate scope good functional group tolerance excellent selectivity.

Язык: Английский

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