Organic Letters, Год журнала: 2025, Номер unknown
Опубликована: Апрель 17, 2025
Direct construction of the piperazine scaffolds with multiple functionalities remains important yet challenging. Herein, a silver-catalyzed formal [3 + 3] heteroannulation aziridines 3-aminoacrylates via ring-opening and vinyl C(sp2)-H amination for direct synthesis tetrasubstituted 1,4,5,6-tetrahydropyrazines is reported. Upon catalytic activation silver Lewis acid, this protocol enables formation two new C-N bonds through selective nucleophilic C-H aminative cyclization cascades, featuring broad substrate scope good functional group tolerance excellent selectivity.
Язык: Английский