Organic Letters, Год журнала: 2025, Номер unknown
Опубликована: Апрель 30, 2025
We have developed a transition-metal-free photocatalytic S-N coupling reaction utilizing sodium organosulfinate and hydroxamic acid to synthesize acylsulfonamides. Employing 2,3,5,6-tetra(9H-carbazol-9-yl)benzonitrile (4CzBN) as photocatalyst, this method enables the preparation of wide range acylsulfonamides from arylhydroxamic acids or N-hydroxycarbamates. Mechanistic studies indicate that generation singlet oxygen (1O2) via Energy Transfer Process (EnT) is crucial for facilitating reaction. This approach offers sustainable efficient pathway acylsulfonamide synthesis under mild conditions.
Язык: Английский