Research and Reports in Urology, Год журнала: 2024, Номер Volume 16, С. 315 - 325
Опубликована: Ноя. 1, 2024
Serum prostate-specific antigen (PSA) is a widely used maker for prostate cancer (PCa) screening. However, its correlation with PCa varies, partly due to ethnic differences. This study investigated the between PSA and diagnosis as well burden of disease in Tanzanian community.
Язык: Английский
Cancers, Год журнала: 2024, Номер 16(21), С. 3675 - 3675
Опубликована: Окт. 30, 2024
Epidemiological data are crucial for adopting primary and secondary prevention strategies to develop screening protocols against prostate cancer (PCa). Despite the comprehensive characterization of PCa across White Black men, there is a lack from Mexican population. This manuscript presents Can.Prost registry that captures trends over past two decades in Mexico City; furthermore, we aimed compare clinical differences oncological outcomes before after promotion early detection actions through campaign occurred 2014.
Язык: Английский
Процитировано
1
NEJM Evidence, Год журнала: 2024, Номер 3(5)
Опубликована: Апрель 23, 2024
Black men in the United States experience a substantial and disproportionate burden from prostate cancer. Compared with other racial ethnic groups, have highest cancer incidence mortality rates, rate of distant-stage cancer, are diagnosed at younger age.1 Microsimulation models suggest that annually screening 45 to 69 years age could substantially reduce while limiting overdiagnosis.2 The American Urological Association (AUA) Cancer Society (ACS) guidelines long recommended earlier for men, beginning either 40 or depending on family history
Язык: Английский
Процитировано
0
Expert Review of Anticancer Therapy, Год журнала: 2024, Номер unknown, С. 1 - 4
Опубликована: Авг. 30, 2024
Язык: Английский
Процитировано
0
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Ноя. 4, 2024
ABSTRACT Background As healthcare moves from a one-size-fits-all approach towards precision care, individual risk prediction is an important step in disease prevention and early detection. Biobank-linked systems can generate knowledge about genomic test the impact of implementing that care. Risk-stratified prostate cancer screening one clinical application might benefit such approach. Methods We developed translation pipeline for genomics-informed national system. used data 585,418 male participants Veterans Affairs (VA) Million Veteran Program (MVP), among whom 101,920 self-identify as Black/African-American, to develop validate Prostate CAncer integrated Risk Evaluation (P-CARE) model, model based on polygenic score, family history, genetic principal components. The was externally validated 18,457 PRACTICAL Consortium participants. A novel blended genome-exome (BGE) platform laboratory assay both P-CARE rare variants cancer-associated genes, including additional validation 74,331 samples All Us Research Program. Results In overall ancestry-stratified analyses, score 601 associated with any, metastatic, fatal MVP PRACTICAL. Values at ≥80th percentile multiancestry cohort were hazard ratios (HR) 2.75 (95% CI 2.66-2.84), 2.78 2.54-2.99), 2.59 2.22-2.97) MVP, respectively, compared median. When high– low-risk groups defined HR>1.5 HR<0.75 metastatic cancer, 220,062 (37.6%) high-risk vs.146,826 (25.1%) had 47.9% vs. 14.1%, 9.3% 2.0%, 3.6% 0.8% cumulative cause-specific incidence by age 90, respectively. reports are now being implemented trial VA system (Clinicaltrials.gov NCT05926102 ). Conclusions consisting components describes clinically gradient diverse patient population demonstrates potential learning health implement evaluate care approaches.
Язык: Английский
Процитировано
0
Contemporary Clinical Trials, Год журнала: 2024, Номер 147, С. 107737 - 107737
Опубликована: Ноя. 10, 2024
Язык: Английский
Процитировано
0
Research and Reports in Urology, Год журнала: 2024, Номер Volume 16, С. 315 - 325
Опубликована: Ноя. 1, 2024
Serum prostate-specific antigen (PSA) is a widely used maker for prostate cancer (PCa) screening. However, its correlation with PCa varies, partly due to ethnic differences. This study investigated the between PSA and diagnosis as well burden of disease in Tanzanian community.
Язык: Английский
Процитировано
0