Long COVID science, research and policy

Nature Medicine, Год журнала: 2024, Номер 30(8), С. 2148 - 2164

Опубликована: Авг. 1, 2024

Long COVID represents the constellation of post-acute and long-term health effects caused by SARS-CoV-2 infection; it is a complex, multisystem disorder that can affect nearly every organ system be severely disabling. The cumulative global incidence long around 400 million individuals, which estimated to have an annual economic impact approximately $1 trillion-equivalent about 1% economy. Several mechanistic pathways are implicated in COVID, including viral persistence, immune dysregulation, mitochondrial dysfunction, complement endothelial inflammation microbiome dysbiosis. devastating impacts on individual lives and, due its complexity prevalence, also has major ramifications for systems economies, even threatening progress toward achieving Sustainable Development Goals. Addressing challenge requires ambitious coordinated-but so far absent-global research policy response strategy. In this interdisciplinary review, we provide synthesis state scientific evidence assess human health, systems, economy metrics, forward-looking roadmap.

Язык: Английский

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Long COVID: a clinical update

The Lancet, Год журнала: 2024, Номер 404(10453), С. 707 - 724

Опубликована: Июль 31, 2024

Язык: Английский

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Long Covid Defined

New England Journal of Medicine, Год журнала: 2024, Номер 391(18), С. 1746 - 1753

Опубликована: Июль 31, 2024

Язык: Английский

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Mapping the effectiveness and risks of GLP-1 receptor agonists

Nature Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Язык: Английский

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Early biological markers of post-acute sequelae of SARS-CoV-2 infection

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 29, 2024

To understand the roles of acute-phase viral dynamics and host immune responses in post-acute sequelae SARS-CoV-2 infection (PASC), we enrolled 136 participants within 5 days their first positive real-time PCR test. Participants self-collected up to 21 nasal specimens 28 post-symptom onset; interviewer-administered questionnaires blood samples were collected at enrollment, 9, 14, 21, 28, month 4 8 onset. Defining PASC as presence any COVID-associated symptom 4-month visit, compared markers (quantity duration RNA load, infectious plasma N-antigen level) (IL-6, IL-10, TNF-α, IFN-α, IFN-γ, MCP, IP-10, Spike IgG) over acute period. Compared those who fully recovered, reporting demonstrated significantly higher maximum levels N-antigen, burden shedding, lower Spike-specific IgG 9 post-illness No significant differences identified among a panel markers. Our results suggest early associated play role pathogenesis PASC, highlighting importance understanding biological natural history PASC.

Язык: Английский

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Navigating neurologic post-COVID-19 conditions in adults: Management strategies for cognitive dysfunction, headaches and neuropathies

Life Sciences, Год журнала: 2025, Номер 362, С. 123374 - 123374

Опубликована: Янв. 5, 2025

Язык: Английский

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COVID-19 Transmission During the Winter 2023-24 Surge: A Comparative Analysis of Surveillance Estimates in the U.S., Canada, and the U.K.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Background: Better estimates of COVID-19 transmission are needed since testing has declined. The present investigation examined the correspondence among during winter 2023-24 surge using wastewater-derived for U.S. and Canada testing-derived estimate in U.K. to evaluate validity provide vital public health data on levels. Methods: study used from (Pandemic Mitigation Collaborative dashboard) (COVID-19 Resources testing-based surveillance (Health Security Agency). Data sets were linked by date relative peak within each set. Analyses focused UKHSA period November 2023 March 2024. 1) described day, 2) agreement patterns via correlations, 3) absolute proportion population actively infectious across two months transmission, 4) populations infected months. Results: On day infections, an estimated 1.95 million people U.S., 148 thousand Canada, 431 U.K., meaning 2.5%-4.5% these infectious. Estimates showed high throughout wave, especially between (r=.974, p<.001). During 93.5% 68.8% had excellent or better with data. An >100 months, 20.9%-26.0% population. Discussion: Findings support ongoing significance documenting levels surge. Transmission methodologies nations. More resources prevent diagnose treat long-term sequelae.

Язык: Английский

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A longitudinal description of the health-related quality of life among high-risk individuals after SARS-CoV-2 infection: a Dutch multicenter observational cohort study

Open Forum Infectious Diseases, Год журнала: 2025, Номер 12(2)

Опубликована: Янв. 27, 2025

Abstract Background Health-related quality of life (HRQoL) data post–COVID-19 in patients with medical conditions associated severe disease are lacking. Here, we assess the longitudinal impact COVID-19 on HRQoL and employment status individuals at high risk. Methods This multicenter prospective cohort study included risk for who were hospitalized or not-hospitalized SARS-CoV-2 infection (September 2021–February 2024). Questionnaires about collected 3, 6, 12 months retrospectively recalled reported pre–COVID-19. With a mixed effects model, assessed course factors changes utility score. Results Among 332 (median age, 59.8 years [IQR, 48.8–67.1]; 50.6% female), 184 (55.4%) (intensive care unit admission, 12.0%). High-risk solid organ transplantation (19.6%), hematologic malignancies (28.0%), immunosuppressive medication use (56.6%). The median score declined from 0.85 (IQR, 0.74–1.00) pre–COVID-19 to 0.81 (0.70–0.92) (P = .007). Solid transplant recipients requiring oxygen therapy an decrease over 1 year. At months, 45.3% all employed responders had sick leave related symptoms. Employed lower scores (0.81 0.72–0.91]) than those did not (0.89 [0.86–1.00], P .002). Conclusions experience substantial decline post–COVID-19. Moreover, almost half participants COVID-19–related leave, correlating HRQoL. highlights continuous burden this vulnerable population supports implementation preventive approaches.

Язык: Английский

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Prevalence of cardiovascular symptoms in post-acute COVID-19 syndrome: a meta-analysis

BMC Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 6, 2025

Since its emergence in 2019, COVID-19 has continued to pose significant threats both the physical and mental health of global population, as well healthcare systems worldwide (Raman et al., Eur Heart J 43:1157–1172, 2022). Emerging evidence indicates that may lead post-acute syndrome (PACS) with cardiovascular implications, potentially driven by factors such ACE2 interaction viruses, systemic inflammation, endothelial dysfunction. However, there remains a limited amount research on manifestations PACS, which delay development optimal treatment strategies for affected patients. Therefore, it is crucial investigate prevalence sequelae patients determine whether infection acts an independent risk factor these outcomes. This meta-analysis adhered PRISMA guidelines was registered PROSPERO (CRD42024524290). A systematic search PubMed, Embase, Cochrane Library conducted up March 17, 2024. The primary outcomes included hypertension, palpitations, chest pain, pooled effect estimate reported proportions odds ratios (ORs) 95% confidence intervals (CIs). Sensitivity subgroup analysis were performed assess robustness results identify sources heterogeneity. total 37 studies, encompassing 2,965,467 patients, analysis. Pooled from case–control studies revealed that, compared control group, ORs pain group 4.0 (95% CI: 1.6, 10.0). palpitation hypertension 3.4 1.1, 10.2) 1.7 1.8), respectively. PACS experiencing palpitation, 22% 14%, 33%), 18% 13%, 24%), 19% 12%, 31%), Our findings indicate 15% experience sequelae. Furthermore, significantly increases likelihood developing uninfected individuals. Future should prioritize investigating underlying pathological mechanisms targeted preventive management strategies. CRD42024524290.

Язык: Английский

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Rates of infection with other pathogens after a positive COVID-19 test versus a negative test in US veterans (November, 2021, to December, 2023): a retrospective cohort study

The Lancet Infectious Diseases, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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