Dynamic structure factor of undulating vesicles: finite-size and spherical geometry effects with application to neutron spin echo experiments
The European Physical Journal E,
Год журнала:
2024,
Номер
47(2)
Опубликована: Фев. 1, 2024
Язык: Английский
Lipid Lateral Diffusion: Mechanisms and Modulators
Soft Matter,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
The
lateral
diffusion
of
lipids
within
a
membrane
is
paramount
importance,
serving
as
central
mechanism
in
numerous
physiological
processes
including
cell
signaling,
trafficking,
protein
activity
regulation,
and
energy
transduction
pathways.
This
review
offers
comprehensive
overview
lipid
model
biomembrane
systems
explored
through
the
lens
neutron
scattering
techniques.
We
examine
diverse
models
explore
various
factors
influencing
this
fundamental
process
dynamics.
Additionally,
we
offer
thorough
summary
how
different
membrane-active
compounds,
drugs,
antioxidants,
stimulants,
proteins,
affect
diffusion.
Our
analysis
unveils
intricate
interplay
between
these
additives
membranes,
shedding
light
on
their
dynamic
interactions.
elucidate
that
interaction
governed
by
complex
combination
multiple
physical
state
charge
membrane,
concentration
additives,
molecular
architecture
spatial
distribution
membrane.
In
conclusion,
briefly
discuss
future
directions
areas
requiring
further
investigation
realm
diffusion,
highlighting
need
to
study
more
realistic
systems.
Язык: Английский
Inelastic neutron scattering and spectroscopy methods to characterize dynamics in colloidal and soft matter systems
Advances in Colloid and Interface Science,
Год журнала:
2024,
Номер
326, С. 103135 - 103135
Опубликована: Март 18, 2024
Colloidal
systems
and
soft
materials
are
well
suited
to
neutron
scattering,
the
community
has
readily
adopted
elastic
scattering
techniques
investigate
their
structure.
Due
unique
properties,
neutrons
may
also
be
used
characterize
dynamics
of
over
a
wide
range
length
time
scales
in
situ.
Both
static
structures
an
understanding
how
molecules
move
about
equilibrium
positions
is
essential
if
we
deliver
on
promise
rationally
designing
materials.
In
this
review
introduce
basics
spectroscopy
explore
ways
which
inelastic
can
study
colloidal
Illustrative
examples
chosen
that
highlight
phenomena
suitable
for
investigation
using
suite
techniques.
Язык: Английский
Nanoscale dynamics in model phospholipid biomembranes probed by muon spin resonance spectroscopy: The effects of membrane composition and temperature on acyl chain and cholesterol motion
Chemistry and Physics of Lipids,
Год журнала:
2025,
Номер
unknown, С. 105496 - 105496
Опубликована: Май 1, 2025
Язык: Английский
2023 NIST Center for Neutron Research Accomplishments and Opportunities
Опубликована: Сен. 14, 2023
Язык: Английский
Applications of neutron spin echo in soft matter
Frontiers in Physics,
Год журнала:
2023,
Номер
11
Опубликована: Ноя. 15, 2023
Soft
matter
systems
exhibit
diversity
and
intricacy
in
their
structures
properties,
with
dynamic
behaviors
structural
changes
spanning
wide
time
length
scales.
Gaining
insight
into
the
internal
dynamics
of
soft
systems,
as
well
interactions
among
molecules
particles,
contributes
to
a
deeper
comprehension
microscopic
matter.
Moreover,
this
endeavor
has
significant
biomedical
materials
engineering
implications.
This
review
focuses
on
applications
spin-echo
small-angle
neutron
scattering
(SESANS)
high-resolution
spin
echo
(NSE)
spectroscopy
science,
particularly
complex
fluids
biomolecular
systems.
NSE
remarkable
temporal
resolution
sensitivity
towards
molecular-scale
behaviors.
Therefore,
it
provides
comprehensive
insights
microscale
phenomena
such
rheological
behaviors,
stability,
aggregation
colloids;
domain
conformational
proteins;
collective
lipid
membranes
other
molecules,
surfactants
within
microemulsions.
technique
helps
reveal
nature
these
providing
valuable
advances
biomedicine,
chemistry.
Язык: Английский
Detailed dynamical features of the slow hydration water in the vicinity of poly(ethylene oxide) chains
The Journal of Chemical Physics,
Год журнала:
2024,
Номер
160(6)
Опубликована: Фев. 8, 2024
Poly(ethylene
oxide)
(PEO)
is
a
well-known
biocompatible
polymer
and
has
widely
been
used
for
medical
applications.
Recently,
we
have
investigated
the
dynamic
behavior
of
hydration
water
in
vicinity
PEO
chains
at
physiological
temperature
shown
presence
slow
with
diffusion
coefficient
one
order
magnitude
less
than
that
bulk
water.
This
could
be
evidence
intermediate
critical
biocompatibility;
however,
its
detailed
dynamical
features
were
not
established.
In
this
article,
analyze
quasi-elastic
neutron
scattering
from
through
mode
distribution
analysis
present
microscopic
picture
as
well
relation
to
cold
crystallization.
Язык: Английский
Modulation of Phase Behavior and Microscopic Dynamics in Cationic Vesicles by 1-Decyl-3-methylimidazolium Bromide
Langmuir,
Год журнала:
2023,
Номер
40(1), С. 504 - 518
Опубликована: Дек. 21, 2023
Synthetic
cationic
lipids
have
garnered
significant
attention
as
promising
candidates
for
gene/DNA
transfection
in
therapeutic
applications.
The
phase
behavior
of
the
vesicles
formed
by
these
is
intriguing,
revealing
intricate
connections
to
structure
and
dynamics
membrane.
These
phenomena
emerge
from
complex
interplay
between
hydrophobic
electrostatic
interactions
lipids.
In
this
study,
we
explore
impact
an
ionic
liquid-based
surfactant,
1-decyl-3-methylimidazolium
bromide
(DMIM[Br]),
on
structural,
dynamical,
dihexadecyldimethylammonium
(DHDAB)
vesicles.
Our
investigations
indicate
that
addition
DMIM[Br]
increases
vesicle
size
while
thinning
Further,
also
induces
substantial
changes
membrane
behavior.
At
10
25
mol
%,
eliminates
pre-transition
coagel
intermediate
crystalline
(IC)
decreases
onset
temperature
main
transition
fluid
phase.
cooling
cycle,
further
formation
gel
This
reminiscent
non-synchronous
ordering
observed
DODAB
membrane,
a
longer-chain
counterpart
DHDAB.
Interestingly,
at
40
%
DMIM[Br],
largely
suppressed.
Neutron
scattering
data
provide
evidence
enhances
lipid
mobility
phases,
suggesting
acts
plasticizer,
enhancing
fluidity
across
all
phases.
findings
infer
modulates
membrane's
fluidity,
two
essential
ingredients
efficient
transport
cargo,
controlling
balance
interactions.
Язык: Английский
Antivesiculation and Complete Unbinding of Tail-Tethered Lipids
Langmuir,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 8, 2024
We
report
the
effect
of
tail-tethering
on
vesiculation
and
complete
unbinding
bilayered
membranes.
Amphiphilic
molecules
a
bolalipid,
resembling
tail-tethered
molecular
structure
archaeal
lipids,
with
two
identical
zwitterionic
phosphatidylcholine
headgroups
self-assemble
into
large
flat
lamellar
membrane,
in
contrast
to
multilamellar
vesicles
(MLVs)
observed
its
counterpart,
monopolar
nontethered
lipids.
The
antivesiculation
is
confirmed
by
small-angle
X-ray
scattering
(SAXS)
cryogenic
transmission
electron
microscopy
(cyro-TEM).
With
net
charge
zero
higher
bending
rigidity
membrane
(confirmed
neutron
spin
echo
(NSE)
spectroscopy),
current
theory
would
predict
that
membranes
should
stack
each
other
(aka
"bind")
due
dominant
van
der
Waals
attraction,
while
outcome
nonstacking
("unbinding")
suggests
needs
include
entropic
contribution
for
nonvesicular
structures.
This
pioneers
an
understanding
how
amphiphiles
affects
structure,
enabling
better
control
over
final
nanoscale
morphology.
Язык: Английский
Gaussian model of fluctuating membrane and its scattering properties
Physical review. E,
Год журнала:
2024,
Номер
110(3)
Опубликована: Сен. 20, 2024
A
mathematical
model
is
developed
to
jointly
analyze
elastic
and
inelastic
scattering
data
of
fluctuating
membranes
within
a
single
theoretical
framework.
The
builds
on
nonhomogeneously
clipped
time-dependent
Gaussian
random
field.
This
specific
approach
provides
one
with
general
analytical
expressions
for
the
intermediate
function
any
number
sublayers
in
membrane
arbitrary
contrasts.
illustrated
analysis
small-angle
x-ray
neutron
as
well
spin-echo
measured
unilamellar
vesicles
prepared
from
phospholipids
extracted
porcine
brain
tissues.
parameters
fitted
entire
set
are
lengths
chain
head
molecules
that
make
up
membrane,
amplitude
lateral
sizes
bending
deformations,
thickness
fluctuation,
parameter
characterizing
dynamics.
Язык: Английский