AlgaeSperm: Microalgae‐Based Soft Magnetic Microrobots for Targeted Tumor Treatment
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Abstract
Magnetic
microrobots
are
significant
platforms
for
targeted
drug
delivery,
among
which
sperm‐inspired
types
have
attracted
much
attention
due
to
their
flexible
undulation.
However,
mass
production
of
sperm‐like
soft
magnetic
with
high‐speed
propulsion
is
still
challenging
the
need
more
reasonable
structure
design
and
facile
fabrication.
Herein,
a
novel
strategy
proposed
large‐scale
preparation
microalgae‐based
fully
head‐to‐tail
structure,
called
AlgaeSperm
robust
chemo‐photothermal
performance.
This
approach
deposited
Pd@Au
nanoparticles
(NPs)
inside
chlorella
cells,
further
coated
Fe
3
O
4
NPs
polydopamine
layers
form
heads.
Then,
flagella
grafted
via
assembly
@PVP
construct
final
AlgaeSperm.
Under
precessing
fields,
AlgaeSperms
can
achieve
forward
velocity
up
2.3
body
length/s,
highest
best
knowledge.
Besides,
maneuverability
in
swarm
also
verified.
In
vitro
anti‐cancer
experiments
conducted
after
loading
doxorubicin
(DOX)
confirm
excellent
work
offers
paradigm
constructing
great
potential
tumor
treatment.
Язык: Английский
Wireless mechanical and hybrid thrombus fragmentation of ex vivo endovascular thrombosis model in the iliac artery
Applied Physics Reviews,
Год журнала:
2025,
Номер
12(1)
Опубликована: Фев. 24, 2025
This
study
investigates
the
efficacy
of
an
untethered
magnetic
robot
(UMR)
for
wireless
mechanical
and
hybrid
blood
clot
removal
in
ex
vivo
tissue
environments.
By
integrating
x-ray-guided
manipulation
with
UMRs,
we
aim
to
address
challenges
associated
precise
controlled
intervention.
The
nature
size
these
robots
enhance
maneuverability
accessibility
within
complex
vascular
networks,
potentially
improving
efficiency.
We
explore
fragmentation,
chemical
lysis,
dissolution
techniques
that
combine
fragmentation
highlighting
their
potential
targeted
efficient
removal.
Through
experimental
validation
using
endovascular
thrombosis
model
iliac
artery
a
sheep,
demonstrate
direct
revascularization
13-mm-long,
1-day-old
positioned
inside
left
common
artery.
was
achieved
by
deploying
UMR
into
abdominal
aorta
15
min.
Additionally,
both
achieve
greater
volume
rate
change
compared
no
intervention
(control)
lysis
alone.
Mechanical
exhibits
median
0.87
mm3/min
range
2.81
mm3/min,
while
approach
demonstrates
slower
but
more
consistent
removal,
0.45
0.23
mm3/min.
Язык: Английский
Locomotion of paired spermatozoa during flagellar synchronisation
Journal of Fluid Mechanics,
Год журнала:
2025,
Номер
1007
Опубликована: Март 17, 2025
Microorganisms,
such
as
spermatozoa,
exhibit
rich
behaviours
when
in
close
proximity
to
each
other.
However,
their
locomotion
is
not
fully
understood
coupled
mechanically
and
hydrodynamically.
In
this
study,
we
develop
hydrodynamic
models
investigate
the
of
paired
predicting
fine
structure
swimming.
Experimentally,
sperm
pairs
are
observed
transition
between
different
modes
flagellar
synchronisation:
in-phase,
anti-phase
lagged
synchronisation.
Using
our
models,
assess
swimming
performances
these
synchronisation
terms
average
speed,
power
consumption,
efficiency.
The
spermatozoa
shown
depend
on
phase
lag,
waveforms,
mechanical
coupling
heads.
Язык: Английский
Direction-Switchable Self-Thermophoresis Motor with Chiral Antihelical Resonators
ACS Photonics,
Год журнала:
2024,
Номер
11(9), С. 3822 - 3828
Опубликована: Авг. 19, 2024
The
thermophoresis
effect
has
revolutionized
adjustable
manipulation
based
on
physical,
chemical,
and
even
biomolecular
mechanisms.
However,
traditional
self-propelled
devices
lack
reconfigurability
of
their
motion,
hindering
the
dynamic
switching
artificial
spatial
location
motors.
Through
numerical
simulation,
this
paper
delves
into
underexplored
concept
tunable
antihelical
resonators,
which
offer
rich
managing
channels
differential
optical
absorption,
thermal
gradient,
propulsion.
Utilizing
a
pair
oppositely
helical
gold
nanostructures,
we
demonstrate
achievement
direction-switchable
self-thermophoresis
along
with
artificially
controllable
forward
backward
propulsion
as
well
retrace
operation.
To
clarify
mechanism
in
detail,
chiral
circular
dichroism
related
resonant
light
energy
absorption
temperature
gradient
distribution
around
an
particle
are
observed
under
various
circularly
polarized
sources.
We
further
elucidate
rapid
responses
principles
photothermal
successfully
manipulate
self-propulsion.
Additionally,
establish
linear
relationship
between
laser
power
multiphysical
quantities
such
velocity
force,
enabling
quantitative
modulation
motion.
Our
work
paves
way
for
chiroptics
enabled
motion
provides
practically
rational
basis
motors,
nanoparticle
transport,
tracking
techniques,
so
on.
Язык: Английский
Analysis of Robot–Environment Interaction Modes in Anguilliform Locomotion of a New Soft Eel Robot
Actuators,
Год журнала:
2024,
Номер
13(10), С. 406 - 406
Опубликована: Окт. 7, 2024
Bio-inspired
robots
with
elongated
anatomy,
like
eels,
are
studied
to
discover
anguilliform
swimming
principles
and
improve
the
robots’
locomotion
accordingly.
Soft
continuum
replicate
animal–environment
physics
better
than
noncompliant,
rigid,
multi-body
eel
robots.
In
this
study,
a
slender
soft
robot
was
designed
tested
in
an
actual
experiment
still-water
tank.
The
employs
pneumatic
muscles
laterally
connected
flexible
backbone
activated
rhythmic
input.
position
of
seven
markers
mounted
on
robot’s
recorded
using
QualiSys®
Tracking
Manager
(QTM)
1.6.0.1.
system
modeled
as
fully
coupled
fluid–solid
interaction
(FSI)
COMSOL
Multiphysics®
6.1.
Further
data
postprocessing
analysis
were
conducted,
proposing
new
mode
decomposition
algorithm
simulation
data.
Experiments
show
success
velocity
28
mm/s
at
frequency
0.9
Hz.
allowed
modeling
explanation
fluctuation.
Results
disclose
presence
traveling
waves
related
obtained
by
superposition
two
main
modes.
similarities
results
natural
discussed.
It
is
concluded
that
undulation
ruled
dynamic
modes
induced
robot–environment
interaction.
Язык: Английский
Bioinspired Design, Fabrication, and Wing Morphing of 3D‐Printed Magnetic Butterflies
Advanced Intelligent Systems,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
Monarch
butterflies’
remarkable
migratory
abilities,
facilitated
by
their
efficient
wing
structures,
inspire
the
development
of
bioinspired
soft
robots
and
microaerial
vehicles.
This
study
presents
design,
fabrication,
wing‐morphing
behavior
3D‐printed
magnetic
butterflies,
focusing
on
optimal
material
design
parameters
to
replicate
monarch
behavior.
Using
composite
thermoplastic
polyurethane
micron‐sized
Nd
2
Fe
14
B
powder,
12
unique
butterfly
designs—varying
in
size,
vein
patterns,
stiffness—are
fabricated
via
powder
bed
fusion
(PBF)
3D
printing,
resulting
84
specimens.
Lightweight
batch‐producible
with
minimal
postprocessing,
specimens
have
weights
per
unit
area
≈270,
480,
1045
g
m
−2
for
small,
medium,
large
sizes,
respectively.
A
permanent
magnet
induces
deformation
specimens—mimicking
without
embedded
electronics.
systematic
analysis
combining
finite
element
simulations
experiments
reveals
effects
geometric
features,
laser
energy
scale
morphing.
Lower
scales
result
porous,
fast‐bending
specimens,
while
higher
specimen
show
greater
mechanical
strength
varied
deformation,
structures
further
improving
deformation.
The
results
provide
a
detailed
dataset
optimizing
designs
highlighting
potential
PBF
process
creating
lightweight
capable
shape
Язык: Английский