Anticancer profile of coumarin 6-based Ir(iii) photocatalysts under normoxia and hypoxia by ROS generation and NADH oxidation
Inorganic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(17), С. 5435 - 5448
Опубликована: Янв. 1, 2024
Coumarin
6
appended
Ir(
iii
)
photocatalysts
exhibited
light
activated
anticancer
effects
against
cancer
cells
via
mitochondrial
depolarization
driven
apoptosis
by
inducing
type-I
(NADH
oxidation)
and
type-II
(ROS
generation)
mechanisms.
Язык: Английский
Expanding the Horizons of Phototherapy: A Review on the Superior Performance of Chalcogen‐Based Photosensitizers and Photothermal Agents for Cancer Therapy
ChemPhotoChem,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Phototherapy,
encompassing
photodynamic
therapy
(PDT)
and
photothermal
(PTT),
presents
a
promising
cancer
treatment
strategy
with
high
spatial
specificity
minimal
invasiveness.
Optimizing
these
techniques
hinges
on
the
design
of
high‐performance
photosensitizers
(PSs)
agents
(PTAs).
Single‐atom
chalcogen
substitution,
at
both
endocyclic
exocyclic
positions
in
conventional
organic
chromophores,
has
proven
to
be
novel
for
enhancing
their
photophysical
photochemical
properties.
Ideal
PSs/PTAs
exhibit
biocompatibility,
visible‐to‐near‐infrared
(vis–NIR)
absorption,
efficient
triplet
state
harvesting,
feasible
heat
energy
transfer
efficiency.
Moreover,
chalcogen‐based
show
promise
synergistic
multimodal
therapies,
integrating
imaging
treatment.
This
review
comprehensively
examines
recent
advancements
(within
last
five
years)
utilizing
substitution
robust
PDT/PTT.
It
provides
holistic
perspective
spectroscopic
characterization
computational
analyses,
singlet‐oxygen/triplet
quantum
yields,
generation
efficiency,
vitro/in
vivo
biological
evaluations
chalcogen‐substituted
PSs/PTAs.
is
anticipated
that
this
will
stimulate
further
research
endeavors
area.
Язык: Английский
Light–matter interaction at the nano- and molecular scale
The Journal of Chemical Physics,
Год журнала:
2025,
Номер
162(14)
Опубликована: Апрель 8, 2025
Язык: Английский
Planar conjugate donor engineering enhanced photodynamic immunogenic cell death stimulator for efficient Triple-Negative breast cancer immunotherapy
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
unknown, С. 138085 - 138085
Опубликована: Июнь 1, 2025
Язык: Английский
Theoretical Understanding of Photoluminescence and Singlet Oxygen Quantum Yields in a Few Halogenated Fluorescein Dyes
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 30, 2024
Abstract
Visible‐light
absorbing
metal‐free
organic
dyes
are
of
increasing
demand
for
various
optoelectronic
applications
because
their
great
structure‐function
tunability
through
chemical
means.
Several
also
show
huge
potential
in
triplet
photosensitization,
generating
reactive
singlet
oxygen.
Understanding
the
structure‐property
relationships
many
well‐known
fluorescein
is
paramount
importance
designing
next‐generation
energy
efficient
dyes,
which
currently
limited.
For
example,
role
heavy
atoms
excited‐state
deactivations
not
fully
understood
these
dyes.
Herein,
9
halogenated
(Cl,
Br,
I)
with
varied
halogen
concentrations
and
positions
studied
using
time‐dependent
range‐separated
hybrid
combined
polarizable
continuum
model
water
dielectric
accounting
polarization
screening
effects.
Excited
state
energies
via
radiative
non‐radiative
pathways
well
described
0–0
corrected
excitation
energies.
Calculated
results
reasonable
agreement
available
experimental
data.
However,
no
systematic
correlation
found
between
heavy‐atom
effect
calculated
intersystem
crossing/fluorescence
rates.
Not
surprisingly,
to
be
more
pronounced
iodinated
compared
brominated
analogues.
Halogen
position
plays
a
critical
determining
deactivation
All
similar
fluorescence
rates
~10
8
.
Whereas,
crossing
much
smaller
vary
from
2
10
4
Nevertheless,
lower
quantum
yields
some
attributed
large
internal
conversion.
Microscopic
understanding
on
properties
several
reported
here
will
aid
developing
advanced
dye
based
photosensitizers
emitters.
Язык: Английский