Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Авг. 5, 2024

Atherosclerotic cardiovascular disease (ASCVD) is the most important cause of morbidity and mortality worldwide. While it traditionally attributed to lipid accumulation in vascular endothelium, recent research has shown that plaque inflammation an additional driver atherogenesis. Though clinical outcome trials utilizing anti-inflammatory agents have proven promising terms reducing ASCVD risk, imperative identify novel actionable targets are more specific atherosclerosis mitigate adverse effects associated with systemic immune suppression. To end, this review explores contributions various cells from innate adaptive system promoting mitigating by integrating findings experimental studies, high-throughput multi-omics technologies, epidemiological research.

Язык: Английский