Advanced Hydrogel Systems for Local Anesthetic Delivery: Toward Prolonged and Targeted Pain Relief

Gels, Год журнала: 2025, Номер 11(2), С. 131 - 131

Опубликована: Фев. 12, 2025

Local anesthetics (LAs) have been indispensable in clinical pain management, yet their limitations, such as short duration of action and systemic toxicity, necessitate improved delivery strategies. Hydrogels, with biocompatibility, tunable properties, ability to modulate drug release, extensively explored platforms for enhancing LA efficacy safety. This narrative review explores the historical development LAs, physicochemical applications, providing a foundation understanding integration hydrogels anesthetic delivery. Advances thermoresponsive, stimuli-responsive, multifunctional demonstrated significant potential prolonging analgesia reducing exposure preclinical studies, while early findings highlight feasibility thermoresponsive hydrogel formulations. Despite these advancements, challenges burst mechanical instability, regulatory considerations remain critical barriers translation. Emerging innovations, including nanocomposite hydrogels, biofunctionalized matrices, smart materials, offer solutions limitations. Future research should focus on optimizing formulations, expanding validation, integrating advanced fabrication technologies 3D printing artificial intelligence-driven design enhance personalized management. By bridging materials science pharmacology, this provides comprehensive perspective current trends future directions hydrogel-based systems.

Язык: Английский

Advancing tissue engineering through vascularized cell spheroids: building blocks of the future

Biomaterials Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review provides a comprehensive overview of vascularized cell spheroids, highlighting recent advancements in biofabrication, key strategies for engineering vascular networks, and their applications tissue models regenerative medicine.

Язык: Английский