Improving Targeting Specificity of Transcranial Focused Ultrasound in Humans Using a Random Array Transducer: A k-Wave Simulation Study DOI
Zherui Li, Kai Yu, Joshua Kosnoff

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 28, 2025

Abstract Transcranial focused ultrasound (tFUS) has emerged as a promising non-invasive modality for precision neuromodulation. However, the heterogeneous acoustic properties of skull often induce phase aberrations that shift focus and compromise energy delivery. In this study, we developed validated phase-reversal based aberration correction method to enhance targeting specificity tFUS using 128-element random array transducer. Individual head models were constructed from T1-weighted magnetic resonance (MR) images corresponding pseudo-computed tomography (pCT) data accurately represent subject-specific geometries targeted left V5 (V5L) region. Acoustic simulations conducted with k-Wave toolbox by first acquiring free-field pressure waveforms then recording aberrated in presence skull. The differences between these conditions used compute corrective delays each transducer element. Quantitative evaluation metrics such focal overlap target region, axial positioning, delivered demonstrated significant improvements: volume increased 98.70%, mean positioning errors reduced up 14.36%, delivery improved 17.58%. We further proposed approach outperforms conventional ray-tracing methods. results show markedly increases spatial accuracy enhances efficiency deposition customized transducer, paving way effective personalized noninvasive neuromodulation therapies.

Язык: Английский

Improving Targeting Specificity of Transcranial Focused Ultrasound in Humans Using a Random Array Transducer: A k-Wave Simulation Study DOI
Zherui Li, Kai Yu, Joshua Kosnoff

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 28, 2025

Abstract Transcranial focused ultrasound (tFUS) has emerged as a promising non-invasive modality for precision neuromodulation. However, the heterogeneous acoustic properties of skull often induce phase aberrations that shift focus and compromise energy delivery. In this study, we developed validated phase-reversal based aberration correction method to enhance targeting specificity tFUS using 128-element random array transducer. Individual head models were constructed from T1-weighted magnetic resonance (MR) images corresponding pseudo-computed tomography (pCT) data accurately represent subject-specific geometries targeted left V5 (V5L) region. Acoustic simulations conducted with k-Wave toolbox by first acquiring free-field pressure waveforms then recording aberrated in presence skull. The differences between these conditions used compute corrective delays each transducer element. Quantitative evaluation metrics such focal overlap target region, axial positioning, delivered demonstrated significant improvements: volume increased 98.70%, mean positioning errors reduced up 14.36%, delivery improved 17.58%. We further proposed approach outperforms conventional ray-tracing methods. results show markedly increases spatial accuracy enhances efficiency deposition customized transducer, paving way effective personalized noninvasive neuromodulation therapies.

Язык: Английский

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