Parallel Interdigitated Distributed Networks within the Individual Estimated by Intrinsic Functional Connectivity

Neuron, Год журнала: 2017, Номер 95(2), С. 457 - 471.e5

Опубликована: Июль 1, 2017

Certain organizational features of brain networks present in the individual are lost when central tendencies examined group. Here we investigated detailed network organization four individuals each scanned 24 times using MRI. We discovered that distributed known as default is comprised two separate possessing adjacent regions eight or more cortical zones. A distinction between one coupled to hippocampal formation while other not. Further exploration revealed these were juxtaposed with additional themselves fractionate group-defined networks. The collective display a repeating spatial progression multiple zones, suggesting they embedded within broad macroscale gradient. Regions contributing newly defined spatially variable across and distinct networks, raising issues for estimation group-averaged data applied endeavors, including targeted neuromodulation.

Язык: Английский

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Connectivity Predicts deep brain stimulation outcome in Parkinson disease

Annals of Neurology, Год журнала: 2017, Номер 82(1), С. 67 - 78

Опубликована: Июнь 6, 2017

The benefit of deep brain stimulation (DBS) for Parkinson disease (PD) may depend on connectivity between the site and other regions, but which regions whether can predict outcome in patients remain unknown. Here, we identify structural functional profile effective DBS to subthalamic nucleus (STN) test its ability an independent cohort.A training dataset 51 PD with STN was combined publicly available human connectome data (diffusion tractography resting state connectivity) connections reliably associated clinical improvement (motor score Unified Disease Rating Scale [UPDRS]). This then used cohort 44 from a different center.In dataset, electrode distributed network correlated response including supplementary motor area anticorrelation primary cortex (p < 0.001). same predicted patient 0.01). Structural were predictors 0.001) estimated individual average error 15% UPDRS improvement. Results similar using normal subjects or age, sex, matched our patients.Effective is specific that across cohorts. prediction does not require specialized imaging themselves. Ann Neurol 2017;82:67-78.

Язык: Английский

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Mapping Symptoms to Brain Networks with the Human Connectome

New England Journal of Medicine, Год журнала: 2018, Номер 379(23), С. 2237 - 2245

Опубликована: Дек. 5, 2018

Complex neurologic and psychiatric syndromes cannot be understood on the basis of focal brain lesions. Functional neuroimaging, maps interrelated regions called connectome, combination lesion analysis with networks connectome offer a new way to understand function disease.

Язык: Английский

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Parcellating cortical functional networks in individuals

Nature Neuroscience, Год журнала: 2015, Номер 18(12), С. 1853 - 1860

Опубликована: Ноя. 9, 2015

Язык: Английский

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Activity flow over resting-state networks shapes cognitive task activations

Nature Neuroscience, Год журнала: 2016, Номер 19(12), С. 1718 - 1726

Опубликована: Окт. 10, 2016

Язык: Английский

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Network localization of neurological symptoms from focal brain lesions

Brain, Год журнала: 2015, Номер 138(10), С. 3061 - 3075

Опубликована: Авг. 10, 2015

A traditional and widely used approach for linking neurological symptoms to specific brain regions involves identifying overlap in lesion location across patients with similar symptoms, termed mapping. This is powerful broadly applicable, but has limitations when do not localize a single region or stem from dysfunction connected the site rather than itself. newer sensitive such network effects functional neuroimaging of patients, this requires specialized scans beyond routine clinical data, making it less versatile difficult apply are rare transient. In article we show that mapping can be expanded incorporate into symptom localization without need patients. Our three steps: (i) transferring three-dimensional volume onto reference brain; (ii) assessing intrinsic connectivity rest using normative connectome data; (iii) overlapping lesion-associated networks identify common syndrome. We first tested our peduncular hallucinosis, syndrome visual hallucinations following subcortical lesions long hypothesized due on extrastriate cortex. While themselves were heterogeneously distributed little location, 22 23 negatively correlated was compared other (P < 10−5) relative cortical 0.01). Next, generalizability technique by applying additional syndromes: central post-stroke pain, auditory aphasia. each syndrome, heterogeneous had showed significant areas previously implicated expression 10−4). These results suggest producing share involved expression; publically available human data these approaches. Because current no imaging may prove applicable localizing setting lesions. The power limited reflect dysfunction. Boes et al. present novel method leverages link networks. They validate four syndromes, expression.

Язык: Английский

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Prospective Validation That Subgenual Connectivity Predicts Antidepressant Efficacy of Transcranial Magnetic Stimulation Sites

Biological Psychiatry, Год журнала: 2017, Номер 84(1), С. 28 - 37

Опубликована: Ноя. 10, 2017

Язык: Английский

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Transcranial magnetic stimulation in basic and clinical neuroscience: A comprehensive review of fundamental principles and novel insights

Neuroscience & Biobehavioral Reviews, Год журнала: 2017, Номер 83, С. 381 - 404

Опубликована: Окт. 14, 2017

Язык: Английский

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Closed-loop stimulation of temporal cortex rescues functional networks and improves memory

Nature Communications, Год журнала: 2018, Номер 9(1)

Опубликована: Янв. 19, 2018

Abstract Memory failures are frustrating and often the result of ineffective encoding. One approach to improving memory outcomes is through direct modulation brain activity with electrical stimulation. Previous efforts, however, have reported inconsistent effects when using open-loop stimulation target hippocampus medial temporal lobes. Here we use a closed-loop system monitor decode neural from recordings in humans. We apply targeted lateral cortex report that this rescues periods poor This also improves later recall, revealing reliable for enhancement. Taken together, our results suggest such systems may provide therapeutic treating dysfunction.

Язык: Английский

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Brain circuitry of compulsivity

European Neuropsychopharmacology, Год журнала: 2015, Номер 26(5), С. 810 - 827

Опубликована: Дек. 17, 2015

Язык: Английский

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