Pharmaceuticals,
Год журнала:
2024,
Номер
17(11), С. 1537 - 1537
Опубликована: Ноя. 16, 2024
Sitafloxacin
is
a
4th
generation
fluoroquinolone
antibiotic
with
broad
activity
against
wide
range
of
Gram-negative
and
Gram-positive
bacteria.
It
approved
in
Japan
used
to
treat
pneumonia
urinary
tract
infections
(UTIs)
as
well
other
upper
lower
respiratory
infections,
genitourinary
oral
otitis
media.
Compared
fluoroquinolones,
sitafloxacin
displays
low
minimal
inhibitory
concentration
(MIC)
for
many
bacterial
species
but
also
anaerobes,
intracellular
bacteria,
persisters.
Furthermore,
it
has
shown
strong
biofilms
Microbiology and Molecular Biology Reviews,
Год журнала:
2023,
Номер
87(4)
Опубликована: Ноя. 14, 2023
SUMMARYAntibiotic
persistence,
or
the
ability
of
small
subsets
bacteria
to
survive
prolonged
antibiotic
treatment,
is
an
underappreciated
cause
treatment
failure.
Over
past
decade,
researchers
have
discovered
multiple
different
stress
responses
and
mechanisms
that
can
promote
persistence.
However,
many
these
studies
been
completed
in
culture-based
systems
fail
truly
replicate
complexities
host
environment,
it
unclear
whether
defined
One
of
the
most
pressing
challenges
our
era
is
rising
occurrence
bacteria
that
are
resistant
to
antibiotics.
Staphylococci
prominent
pathogens
in
humans,
which
have
developed
multiple
strategies
evade
effects
Infections
caused
by
these
resulted
a
high
burden
on
health
care
system
and
significant
loss
lives.
In
this
study,
we
successfully
engineered
lytic
enzymes
exhibit
an
extraordinary
ability
eradicate
staphylococci.
Our
findings
substantiate
importance
meticulous
lead
candidate
selection
identify
therapeutically
promising
peptidoglycan
hydrolases
with
unprecedented
activity.
Hence,
they
offer
new
avenue
for
treating
staphylococcal
infections.
Antioxidants,
Год журнала:
2024,
Номер
13(4), С. 441 - 441
Опубликована: Апрель 8, 2024
Cordycepin
is
considered
a
major
bioactive
component
in
Cordyceps
militaris
extract.
This
study
was
performed
to
evaluate
the
ameliorative
effect
of
extract
(CME)
and
cordycepin
(CPN)
supplementation
on
intestinal
damage
LPS-challenged
piglets.
The
results
showed
that
CPN
or
CME
significantly
increased
villus
height
(p
<
0.01)
height/crypt
depth
ratio
0.05)
jejunum
ileum
piglets
with
LPS-induced
inflammation.
Meanwhile,
alleviated
oxidative
stress
inflammatory
responses
by
reducing
levels
MDA
pro-inflammatory
cytokines
serum.
Additionally,
modulated
structure
microbiota
enriching
short-chain
fatty
acid-producing
bacteria,
level
butyrate
0.05).
RNA-seq
demonstrated
altered
complement
coagulation-cascade-related
genes
0.05),
including
upregulating
gene
KLKB1
while
downregulating
CFD,
F2RL2,
CFB,
C4BPA,
F7,
C4BPB,
CFH,
C3
PROS1,
which
regulate
activation
involved
immune
responses.
Correlation
analysis
further
potential
relation
between
gut
inflammation,
stress,
In
conclusion,
might
inhibit
inflammation
modulating
its
metabolite
Microbiology Spectrum,
Год журнала:
2022,
Номер
10(5)
Опубликована: Окт. 4, 2022
Tuberculosis
is
difficult
to
treat
due
dormant
cells
formed
in
response
immune
stress
and
stochastically
persisters,
both
of
which
are
tolerant
antibiotics.
Bactericidal
antibiotics
kill
by
corrupting
their
energy-dependent
targets.
We
reasoned
that
stochastic
variation,
or
noise,
the
expression
an
energy-generating
component
will
produce
rare
persister
cells.
In
sorted
M.
tuberculosis
grown
on
acetate,
there
considerable
cell-to-cell
variation
level
mRNA
coding
for
AckA,
acetate
kinase.
Quenching
noise
overexpressing
Pharmaceuticals,
Год журнала:
2024,
Номер
17(11), С. 1537 - 1537
Опубликована: Ноя. 16, 2024
Sitafloxacin
is
a
4th
generation
fluoroquinolone
antibiotic
with
broad
activity
against
wide
range
of
Gram-negative
and
Gram-positive
bacteria.
It
approved
in
Japan
used
to
treat
pneumonia
urinary
tract
infections
(UTIs)
as
well
other
upper
lower
respiratory
infections,
genitourinary
oral
otitis
media.
Compared
fluoroquinolones,
sitafloxacin
displays
low
minimal
inhibitory
concentration
(MIC)
for
many
bacterial
species
but
also
anaerobes,
intracellular
bacteria,
persisters.
Furthermore,
it
has
shown
strong
biofilms
