Molecular Therapy,
Год журнала:
2022,
Номер
30(6), С. 2342 - 2353
Опубликована: Фев. 19, 2022
Type
2
diabetes
mellitus
(DM2)
is
associated
closely
with
non-alcoholic
fatty
liver
disease
(NAFLD)
by
affecting
lipid
metabolism,
which
may
lead
to
steatohepatitis
(NASH),
fibrosis,
and
hepatocellular
carcinoma
(HCC).
N6-methyladenosine
(m6A)
RNA
methylation
an
important
epigenetic
regulation
for
gene
expression
related
HCC
development.
We
developed
a
new
NAFLD
model
oriented
from
DM2
mouse,
spontaneously
progressed
histological
features
of
NASH,
high
incidence.
By
sequencing,
protein
methylated
immunoprecipitation
(MeRIP)-qPCR
analysis,
we
found
that
enhanced
ACLY
SCD1
in
this
human
samples
was
due
excessive
m6A
modification,
but
not
elevation
mature
SREBP1.
Moreover,
targeting
METTL3/14
vitro
increases
level
as
well
triglyceride
cholesterol
production
accumulation
droplets.
sequencing
analysis
revealed
overexpressed
METTL14
binds
mRNA
alters
their
pattern.
Our
findings
demonstrate
mouse
provides
study
platform
DM2-related
reveals
unique
epitranscriptional
regulating
mechanism
metabolism
via
m6A-modified
SCD1.
Cell,
Год журнала:
2022,
Номер
185(14), С. 2401 - 2421
Опубликована: Июль 1, 2022
Ferroptosis,
a
form
of
cell
death
driven
by
iron-dependent
lipid
peroxidation,
was
identified
as
distinct
phenomenon
and
named
decade
ago.
Ferroptosis
has
been
implicated
in
broad
set
biological
contexts,
from
development
to
aging,
immunity,
cancer.
This
review
describes
key
regulators
this
within
framework
metabolism,
ROS
biology,
iron
biology.
Key
concepts
major
unanswered
questions
the
ferroptosis
field
are
highlighted.
The
next
promises
yield
further
breakthroughs
mechanisms
governing
additional
ways
harnessing
for
therapeutic
benefit.
The Journal of Experimental Medicine,
Год журнала:
2021,
Номер
218(6)
Опубликована: Май 12, 2021
Ferroptosis
is
a
type
of
regulated
necrosis
that
triggered
by
combination
iron
toxicity,
lipid
peroxidation,
and
plasma
membrane
damage.
The
upstream
inducers
ferroptosis
can
be
divided
into
two
categories
(biological
versus
chemical)
activate
major
pathways
(the
extrinsic/transporter
the
intrinsic/enzymatic
pathways).
Excessive
or
deficient
ferroptotic
cell
death
implicated
in
growing
list
physiological
pathophysiological
processes,
coupled
to
dysregulated
immune
response.
This
review
focuses
on
new
discoveries
related
how
cells
their
spilled
contents
shape
innate
adaptive
immunity
health
disease.
Understanding
immunological
characteristics
activity
not
only
illuminates
an
intersection
between
but
may
also
lead
development
novel
treatment
approaches
for
immunopathological
diseases.
Cancer Communications,
Год журнала:
2022,
Номер
42(2), С. 88 - 116
Опубликована: Фев. 1, 2022
Abstract
The
hallmark
of
tumorigenesis
is
the
successful
circumvention
cell
death
regulation
for
achieving
unlimited
replication
and
immortality.
Ferroptosis
a
newly
identified
type
dependent
on
lipid
peroxidation
which
differs
from
classical
programmed
in
terms
morphology,
physiology
biochemistry.
broad
spectrum
injury
tumor
tolerance
are
main
reasons
radiotherapy
chemotherapy
failure.
effective
rate
immunotherapy
as
new
treatment
method
less
than
30%.
can
be
seen
radiotherapy,
chemotherapy,
immunotherapy;
therefore,
ferroptosis
activation
may
potential
strategy
to
overcome
drug
resistance
mechanism
traditional
cancer
treatments.
In
this
review,
characteristics
causes
by
briefly
described.
addition,
three
metabolic
regulations
its
crosstalk
with
signaling
pathways
summarized.
Collectively,
these
findings
suggest
vital
role
based
interaction
immunotherapy,
thus,
indicating
remarkable
treatment.
The Journal of Cell Biology,
Год журнала:
2021,
Номер
220(9)
Опубликована: Июль 30, 2021
Ferroptosis
is
a
form
of
iron-dependent
regulated
cell
death
driven
by
uncontrolled
lipid
peroxidation.
Mitochondria
are
double-membrane
organelles
that
have
essential
roles
in
energy
production,
cellular
metabolism,
and
regulation.
However,
their
role
ferroptosis
has
been
unclear
somewhat
controversial.
In
this
Perspective,
I
summarize
the
diverse
metabolic
processes
mitochondria
actively
drive
ferroptosis,
discuss
recently
discovered
mitochondria-localized
defense
systems
detoxify
mitochondrial
peroxides
protect
against
present
new
evidence
for
regulating
outline
outstanding
questions
on
fascinating
topic
future
investigations.
An
in-depth
understanding
functions
will
important
implications
both
fundamental
biology
disease
treatment.
Protein & Cell,
Год журнала:
2021,
Номер
12(11), С. 836 - 857
Опубликована: Апрель 23, 2021
Ferroptosis,
an
iron-dependent
form
of
regulated
cell
death
driven
by
peroxidative
damages
polyunsaturated-fatty-acid-containing
phospholipids
in
cellular
membranes,
has
recently
been
revealed
to
play
important
role
radiotherapy-induced
and
tumor
suppression,
mediate
the
synergy
between
radiotherapy
immunotherapy.
In
this
review,
we
summarize
known
as
well
putative
mechanisms
underlying
crosstalk
ferroptosis,
discuss
interactions
ferroptosis
other
forms
induced
radiotherapy,
explore
combination
therapeutic
strategies
targeting
This
review
will
provide
frameworks
for
future
investigations
cancer
therapy.
