Towards a youth mental health paradigm: a perspective and roadmap

Molecular Psychiatry, Год журнала: 2023, Номер 28(8), С. 3171 - 3181

Опубликована: Авг. 1, 2023

Abstract Most mental disorders have a typical onset between 12 and 25 years of age, highlighting the importance this period for pathogenesis, diagnosis, treatment ill-health. This perspective addresses interactions risk protective factors brain development as key pillars accounting emergence psychopathology in youth. Moreover, we propose that novel approaches towards early diagnosis interventions are required reflect evolution emerging psychopathology, service models, knowledge exchange science practitioners. Taken together, transformative intervention paradigm research clinical care could significantly enhance health young people initiate shift prevention severe disorders.

Язык: Английский

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Spatial and temporal pattern of structure–function coupling of human brain connectome with development

eLife, Год журнала: 2024, Номер 13

Опубликована: Июнь 20, 2024

Brain structural circuitry shapes a richly patterned functional synchronization, supporting for complex cognitive and behavioural abilities. However, how coupling of connectome (SC) (FC) develops its relationships with functions transcriptomic architecture remain unclear. We used multimodal magnetic resonance imaging data from 439 participants aged 5.7–21.9 years to predict connectivity by incorporating intracortical extracortical connectivity, characterizing SC–FC coupling. Our findings revealed that was strongest in the visual somatomotor networks, consistent evolutionary expansion, myelin content, principal gradient. As development progressed, exhibited heterogeneous alterations dominated an increase cortical regions, broadly distributed across somatomotor, frontoparietal, dorsal attention, default mode networks. Moreover, we discovered significantly predicted individual variability general intelligence, mainly influencing frontoparietal Finally, our results demonstrated is positively associated genes oligodendrocyte-related pathways negatively astrocyte-related genes. This study offers insight into maturational principles typical development.

Язык: Английский

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Atypical connectome topography and signal flow in temporal lobe epilepsy

Progress in Neurobiology, Год журнала: 2024, Номер 236, С. 102604 - 102604

Опубликована: Апрель 10, 2024

Язык: Английский

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Morphometric brain organization across the human lifespan reveals increased dispersion linked to cognitive performance

PLoS Biology, Год журнала: 2024, Номер 22(6), С. e3002647 - e3002647

Опубликована: Июнь 20, 2024

The human brain is organized as segregation and integration units follows complex developmental trajectories throughout life. cortical manifold provides a new means of studying the brain’s organization in multidimensional connectivity gradient space. However, how morphometric changes across lifespan remains unclear. Here, leveraging structural magnetic resonance imaging scans from 1,790 healthy individuals aged 8 to 89 years, we investigated age-related global, within- between-network dispersions reveal networks 3D manifolds based on similarity network (MSN), combining multiple features conceptualized “fingerprint” an individual’s brain. Developmental global dispersion unfolded along patterns molecular organization, such acetylcholine receptor. Communities were increasingly dispersed with age, reflecting more disassortative profiles within community. Increasing within-network primary motor association cortices mediated influence age cognitive flexibility executive functions. We also found that secondary sensory decreasingly rest during aging, possibly indicating shift extreme central position manifolds. Together, our results MSN perspective space, providing insights into brain, well performance.

Язык: Английский

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The multiscale brain structural re-organization that occurs from childhood to adolescence correlates with cortical morphology maturation and functional specialization

PLoS Biology, Год журнала: 2025, Номер 23(4), С. e3002710 - e3002710

Опубликована: Апрель 1, 2025

From childhood to adolescence, the structural organization of human brain undergoes dynamic and regionally heterogeneous changes across multiple scales, from synapses macroscale white matter pathways. However, during this period, developmental process multiscale architecture, its association with cortical morphological changes, role in maturation functional remain largely unknown. Here, using two independent multimodal imaging datasets aged 6–14 years, we investigated by constructing an vivo connectome model incorporating tractography, cortico–cortical proximity, microstructural similarity. By employing gradient mapping method, principal derived effectively recapitulated sensory-association axis. Our findings revealed a continuous expansion space development, characterized enhanced differentiation between primary sensory higher-order transmodal regions along gradient. This age-related paralleled morphology. Furthermore, coupling connectivity were correlated specialization refinement, as evidenced participation coefficient. Notably, was associated improved cognitive abilities, such working memory attention performance, potentially underpinned synaptic hormone-related biological processes. These advance our understanding intricate implications for performance.

Язык: Английский

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Spatial and temporal pattern of structure–function coupling of human brain connectome with development

eLife, Год журнала: 2024, Номер 13

Опубликована: Янв. 19, 2024

Brain structural circuitry shapes a richly patterned functional synchronization, supporting for complex cognitive and behavioural abilities. However, how coupling of connectome (SC) (FC) develops its relationships with functions transcriptomic architecture remain unclear. We used multimodal magnetic resonance imaging data from 439 participants aged 5.7-21.9 years to predict connectivity by incorporating intracortical extracortical connectivity, characterizing SC-FC coupling. Our findings revealed that was strongest in the visual somatomotor networks, consistent evolutionary expansion, myelin content, principal gradient. As development progressed, exhibited heterogeneous alterations dominated an increase cortical regions, broadly distributed across somatomotor, frontoparietal, dorsal attention, default mode networks. Moreover, we discovered significantly predicted individual variability general intelligence, mainly influencing frontoparietal Finally, our results demonstrated is positively associated genes oligodendrocyte-related pathways negatively astrocyte-related genes. This study offers insight into maturational principles typical development.

Язык: Английский

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Connectome reorganization associated with temporal lobe pathology and its surgical resection

Brain, Год журнала: 2024, Номер 147(7), С. 2483 - 2495

Опубликована: Май 3, 2024

Network neuroscience offers a unique framework to understand the organizational principles of human brain. Despite recent progress, our understanding how brain is modulated by focal lesions remains incomplete. Resection temporal lobe most effective treatment control seizures in pharmaco-resistant epilepsy (TLE), making this syndrome powerful model study lesional effects on network organization young and middle-aged adults. Here, we assessed downstream consequences lesion its surgical resection brain's structural connectome, explored reorganization relates clinical variables at individual patient level. We included adults with TLE (n = 37) who underwent anterior lobectomy between two imaging time points, as well age- sex-matched healthy controls comparable 31). Core analysis was projection high-dimensional connectome data-derived from diffusion MRI tractography each subject-into lower-dimensional gradients. then compared gradients patients relative before surgery, tracked surgically-induced reconfiguration pre- postoperative examined associations patient-specific phenotypes. Before individuals presented marked changes bilateral temporo-parietal regions, reflecting an increased segregation ipsilateral rest Surgery-induced localized subnetwork, but primarily involved integration contralateral regions Using partial least-squares analysis, uncovered latent signature underlying reorganization, showing that displayed fronto-occipital cortices also had greater preoperative hippocampal atrophy, lower seizure frequency secondarily generalized seizures. Our results bridge their resections large-scale interindividual variability, thus offering new avenues examine fundamental malleability

Язык: Английский

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Longitudinal variation in resilient psychosocial functioning is associated with ongoing cortical myelination and functional reorganization during adolescence

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июль 29, 2024

Abstract Adolescence is a period of dynamic brain remodeling and susceptibility to psychiatric risk factors, mediated by the protracted consolidation association cortices. Here, we investigated whether longitudinal variation in adolescents’ resilience psychosocial stressors during this vulnerable associated with ongoing myeloarchitectural maturation functional networks. We used repeated myelin-sensitive Magnetic Transfer (MT) resting-state neuroimaging ( n = 141), captured adversity exposure adverse life events, dysfunctional family settings, socio-economic status at two timepoints, one years apart. Development toward more resilient functioning was increasing myelination anterolateral prefrontal cortex, which showed stabilized connectivity. Studying depth-specific intracortical MT profiles cortex-wide synchronization maturation, further observed wide-spread reconfiguration cortices paralleled attenuated reorganization increasingly outcomes. Together, resilient/susceptible considerable intra-individual change multi-modal cortical refinement processes local system-level.

Язык: Английский

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Adult lifespan trajectories of neuromagnetic signals and interrelations with cortical thickness

NeuroImage, Год журнала: 2023, Номер 278, С. 120275 - 120275

Опубликована: Июль 13, 2023

Oscillatory power and phase synchronization map neuronal dynamics are commonly studied to differentiate the healthy diseased brain. Yet, little is known about course spatial variability of these features from early adulthood into old age. Leveraging magnetoencephalography (MEG) resting-state data in a cross-sectional adult sample (n = 350), we probed lifespan differences (18-88 years) connectivity interaction effects with sex. Building upon recent attempts link brain structure function, tested correspondence between age on cortical thickness those functional networks. We further direct structure-function relationship at level study sample. found MEG frequency-specific patterns divergence sexes low frequencies. Connectivity exhibited distinct linear trajectories or turning points midlife that might reflect different physiological processes. In delta beta bands, corresponded thickness, pointing co-variation modalities across lifespan. Structure-function coupling was frequency-dependent observed unimodal multimodal regions. Altogether, provide comprehensive overview topographic profile can form basis for neurocognitive clinical investigations. This sheds new light how brain's structural architecture relates fast oscillatory activity.

Язык: Английский

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Canonical neurodevelopmental trajectories of structural and functional manifolds

Опубликована: Янв. 13, 2025

Organisational gradients refer to a continuous low-dimensional embedding of brain regions and can quantify core organisational principles complex systems like the human brain. Mapping how these are altered or refined across development phenotypes is essential understanding relationship between behaviour. Taking developmental approach leveraging longitudinal cross-sectional data from two multi-modal neuroimaging datasets, spanning full neurotypical-neurodivergent continuum, we charted variability structural (N = 887) functional 728) gradients, childhood adolescence (6-19 years old). Across despite differing phenotypes, observe highly similar gradients. These principles, stable development, with exact same ordering early into mid-adolescence. However, there substantial change in strength within those gradients: by modelling trajectories as non-linear splines, show that exhibit sensitive periods development. Specifically, gradually contract space networks become more integrated, whilst manifold expands, indexing specialisation. The coupling follows unimodal-association axis varies individuals, effects concentrated plastic higher-order networks. Importantly, on coupling, networks, attenuated neurodivergent sample. Finally, mapped structure-function onto dimensions psychopathology cognition demonstrate robust predictor cognition, such working memory, but not psychopathology. In summary, clinical community samples, consistent organisation, progressive integration segregation. established life, through their memory.

Язык: Английский

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