Frontiers in Neuroendocrinology, Год журнала: 2024, Номер 76, С. 101162 - 101162
Опубликована: Ноя. 17, 2024
Язык: Английский
Cognitive Affective & Behavioral Neuroscience, Год журнала: 2024, Номер 24(2), С. 228 - 245
Опубликована: Фев. 14, 2024
Abstract Anxiety disorders affect millions of people worldwide and present a challenge in neuroscience research because their substantial heterogeneity clinical presentation. While great deal progress has been made understanding the neurobiology fear anxiety, these insights have not led to effective treatments. Understanding relationship between phenotypic underlying biology is critical first step solving this problem. We show translation, reverse computational modeling can contribute refined, cross-species anxiety as well disorders. More specifically, we outline how animal models be leveraged develop testable hypotheses humans by using targeted, approaches ethologically informed behavioral paradigms. discuss translational that guide prioritize nontraditional species. Finally, advocate for use harmonize cross-methodology into anxiety. Together, approach will help bridge widening gap currently conceptualize diagnose disorders, aid discovery better treatments conditions.
Язык: Английский
Процитировано
12
Current Biology, Год журнала: 2024, Номер unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
7
Опубликована: Фев. 14, 2025
Oxytocin receptor (Oxtr) signaling influences complex social behaviors in diverse species, including monogamy prairie voles. How Oxtr regulates specific components of attachment and the neural mechanisms mediating them remains unknown. Here, we examine voles lacking demonstrate that pair bonding comprises distinct behavioral modules: preference for a bonded partner, rejection novel potential mates. Our longitudinal study shows sex-specifically early interactions between partners facilitating formation partner preference. Additionally, suppresses promiscuity towards mates following bonding, contributing to rejection. function coordinated patterns gene expression regions implicated oxytocin paraventricular nucleus hypothalamus, principal source oxytocin. Thus, controls genetically separable coordinates development substrates attachment.
Язык: Английский
Процитировано
1
Animal Behaviour, Год журнала: 2025, Номер 222, С. 123098 - 123098
Опубликована: Фев. 18, 2025
Язык: Английский
Процитировано
1
Hormones and Behavior, Год журнала: 2024, Номер 162, С. 105528 - 105528
Опубликована: Март 18, 2024
Язык: Английский
Процитировано
5
Hormones and Behavior, Год журнала: 2024, Номер 160, С. 105487 - 105487
Опубликована: Янв. 27, 2024
Язык: Английский
Процитировано
4
Comprehensive physiology, Год журнала: 2025, Номер 15(1)
Опубликована: Фев. 1, 2025
ABSTRACT Psychological stress has emerged as a critical risk factor for cardiovascular disease, especially in women. While female participation clinical research improved, sex‐specific data analysis and reporting often remain inadequate, limiting our ability to draw definitive conclusions Conversely, preclinical studies consistently demonstrate adverse effects of on health, yet the molecular mechanisms underlying this association elusive. Evidence suggests that IHD pathogenesis is more complex than males, involving multiple factors, including inflammation, contractile dysfunction, bioenergetic impairment, remodeling. However, many these are primarily derived from male studies, investigations models limited, hindering understanding biological pathways. This particularly concerning given increasing prevalence ischemic heart disease postmenopausal In order fully elucidate impact cardiac health develop targeted interventions, further essential.
Язык: Английский
Процитировано
0
PLoS Biology, Год журнала: 2025, Номер 23(2), С. e3003002 - e3003002
Опубликована: Фев. 10, 2025
In multi-animal tracking, addressing occlusion and crowding is crucial for accurate behavioral analysis. However, in situations where generate complex interactions, achieving pose tracking remains challenging. Therefore, we introduced virtual marker (vmTracking), which uses markers individual identification. Virtual are labels derived from conventional markerless tools, such as DeepLabCut (maDLC) Social LEAP Estimate Animal Poses (SLEAP). Unlike physical markers, exist only within the video attribute features to individuals, enabling consistent identification throughout entire while keeping animals reality. Using these cues, annotations were applied videos, was conducted with single-animal (saDLC) SLEAP’s method. vmTracking minimized manual corrections annotation frames needed training, efficiently tackling crowding. Experiments multiple mice, fish, human dancers confirmed vmTracking’s variability applicability. These findings could enhance precision reliability of methods used analysis naturalistic social behaviors animals, providing a simpler yet more effective solution.
Язык: Английский
Процитировано
0
Опубликована: Фев. 14, 2025
Oxytocin receptor (Oxtr) signaling influences complex social behaviors in diverse species, including monogamy prairie voles. How Oxtr regulates specific components of attachment and the neural mechanisms mediating them remains unknown. Here, we examine voles lacking demonstrate that pair bonding comprises distinct behavioral modules: preference for a bonded partner, rejection novel potential mates. Our longitudinal study shows sex-specifically early interactions between partners facilitating formation partner preference. Additionally, suppresses promiscuity towards mates following bonding, contributing to rejection. function coordinated patterns gene expression regions implicated oxytocin paraventricular nucleus hypothalamus, principal source oxytocin. Thus, controls genetically separable coordinates development substrates attachment.
Язык: Английский
Процитировано
0
Biological Psychiatry Global Open Science, Год журнала: 2025, Номер unknown, С. 100538 - 100538
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0