Capturing the emergent dynamical structure in biophysical neural models DOI Creative Commons
Borjan Milinkovic, Lionel Barnett, Olivia Carter

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 22, 2024

Abstract Complex neural systems can display structured emergent dynamics. Capturing this structure remains a significant scientific challenge. Using information theory, we apply Dynamical Independence (DI) to uncover the dynamical in minimal 5-node biophysical model, shaped by interplay of two key aspects brain organisation: integration and segregation. In our study, functional within model is modulated global coupling parameter, while segregation influenced adding noise, which counteracts coupling. DI defines dimensionally-reduced macroscopic variable (e.g., coarse-graining) as extent that it behaves an independent process, distinct from micro-level We measure dependence (a departure independence) for variables across spatial scales. Our results indicate degree emergence relatively minimised at balanced points maximised extremes. Additionally, method identifies dynamics are localised microlevel nodes, thereby elucidating through relationship between microscopic processes. find deviation point less localised, more distributed identified DI. This finding suggests balance associated with lower levels (higher dependence), may be crucial sustaining coherent, structures. work also provides complete computational implementation identification could applied both silico vivo. Author summary Understanding how complex give rise patterns central challenge neuroscience. Emergence, where structures appear underlying interactions, plays role function, yet identifying specific involved elusive. Traditionally, methods have quantified but struggled pinpoint itself. develop method, based on quantity called (DI), simultaneously captures reveals neurophysiological data. explore segregation—two organisational principles brain—affects show finely system produces highly coherent structures, extreme deviations lead distributed, framework theoretical models potentially empirical data, advancing understanding brain’s organisation higher-order

Язык: Английский

An integrative, multiscale view on neural theories of consciousness DOI Creative Commons
Johan F. Storm, P. Christiaan Klink, Jaan Aru

и другие.

Neuron, Год журнала: 2024, Номер 112(10), С. 1531 - 1552

Опубликована: Март 5, 2024

How is conscious experience related to material brain processes? A variety of theories aiming answer this age-old question have emerged from the recent surge in consciousness research, and some are now hotly debated. Although most researchers so far focused on development validation their preferred theory relative isolation, article, written by a group scientists representing different theories, takes an alternative approach. Noting that various often try explain aspects or mechanistic levels consciousness, we argue do not necessarily contradict each other. Instead, several them may converge fundamental neuronal mechanisms be partly compatible complementary, multiple can simultaneously contribute our understanding. Here, consider unifying, integration-oriented approaches been largely neglected, seeking combine valuable elements theories.

Язык: Английский

Процитировано

35
A dynamic bifurcation mechanism explains cortex-wide neural correlates of conscious access DOI Creative Commons
Ulysse Klatzmann, Seán Froudist‐Walsh,

Daniel P. Bliss

и другие.

Cell Reports, Год журнала: 2025, Номер 44(3), С. 115372 - 115372

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
A Reconsideration of the Core and Matrix Classification of Thalamocortical Projections DOI
S. Murray Sherman, W. Martin Usrey

Journal of Neuroscience, Год журнала: 2024, Номер 44(24), С. e0163242024 - e0163242024

Опубликована: Июнь 12, 2024

In 1998, Jones suggested a classification of thalamocortical projections into core and matrix divisions (Jones, 1998). this classification, are specific, topographical, innervate middle cortical layers, serve to transmit specific information the cortex for further analysis; projections, in contrast, diffuse, much less topographic, upper especially Layer 1, more global, modulatory function, such as affecting levels arousal. This has proven influential studies relationships. Whereas it may be case that clear subset connections fit motif, since they we argue there is no evidence any single class encompasses remainder claimed matrix. Instead, great morphological variation made by fitting neither nor classification. We thus conclude core/matrix should abandoned, because its application not helpful providing insights interactions can even misleading. As one example latter, recent suggestions indicate equivalent first-order thalamic relays (i.e., those relay subcortical cortex) higher-order from area another), but available does support relationship. All points need replace grouping with complete projections.

Язык: Английский

Процитировано

5
Unravelling consciousness and brain function through the lens of time, space, and information DOI Creative Commons
Andrea I. Luppi, Fernando Rosas, Pedro A. M. Mediano

и другие.

Trends in Neurosciences, Год журнала: 2024, Номер 47(7), С. 551 - 568

Опубликована: Май 31, 2024

Disentangling how cognitive functions emerge from the interplay of brain dynamics and network architecture is among major challenges that neuroscientists face. Pharmacological pathological perturbations consciousness provide a lens to investigate these complex challenges. Here, we review recent advances about brain's functional organisation have been driven by common denominator: decomposing function into fundamental constituents time, space, information. Whereas unconsciousness increases structure-function coupling across scales, psychedelics may decouple structure. Convergent effects also emerge: anaesthetics, psychedelics, disorders can exhibit similar reconfigurations unimodal-transmodal axis. Decomposition approaches reveal potential translate discoveries species, with computational modelling providing path towards mechanistic integration.

Язык: Английский

Процитировано

4
Multiscale organization of neuronal activity unifies scale-dependent theories of brain function DOI
Brandon R. Munn, Eli J. Műller, Itia A. Favre‐Bulle

и другие.

Cell, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

4
Binaural Pulse Modulation (BPM) as an Adjunctive Treatment for Anxiety: A Pilot Study DOI Creative Commons
Gerry Leisman,

Joseph Wallach,

Yanin Machado-Ferrer

и другие.

Brain Sciences, Год журнала: 2025, Номер 15(2), С. 147 - 147

Опубликована: Янв. 31, 2025

Background: Treating psychiatric illnesses or influencing mental states with neurofeedback is challenging, likely due to the limited spatial specificity of EEG and complications arising from inadequate signal-to-noise ratio reduction single-trial EEG. Objective: This pilot study aimed investigate feasibility employing a binaural pulse mode-modulation (BPM) device reduce anxiety by self-regulation. We desired determine whether could be significantly reduced regulated using BPM-type systems. Methods: Sixty adult participants were examined self-reported tests (COVID Stress Scale, Generalized Anxiety Disorder 7, Beck Depression Inventory-II), which completed before treatment, after four weeks, 12 weeks post-treatment. BPM produced two frequencies combined create through differential auditory tone presentations. The participant calibrated suitable target for optimal treatment efficacy. Each adjusted enhance emotional intensity felt when envisioning an experience comparable significance while performing cognitive task concurrently listening music. “treatment” relied on individual’s regulation pulses obtain state. training concentrated particular facets their psychological challenges tone, adjusting knob until sound amplified intended Another was turned intensify state associated distress reduction. Results: On measures, group better than sham (control) groups (p < 0.01). These findings indicate that over four-week intervention period, similarly effective. GAD-7, significant difference time noted at end experimental group, average GAD-7 score being lower Conclusions: seems induce short-term alteration in levels during therapy. study’s limitations are examined, recommendations future research provided.

Язык: Английский

Процитировано

0
Context‐Sensitive Conscious Interpretation and Layer‐5 Pyramidal Neurons in Multistable Perception DOI Creative Commons
Talis Bachmann

Brain and Behavior, Год журнала: 2025, Номер 15(3)

Опубликована: Март 1, 2025

There appears to be a fundamental difference between the two ways of how an object becomes perceptually experienced. One occurs when preconscious object-specifying sensory data processing crosses certain threshold so that constituents depiction become consciously The other already experienced features interpreted as belonging visual category. Surprisingly, experimental facts about neural markers conscious access gathered far do not allow us distinguish mechanisms responsible for these varieties. A cortical multicompartment layer-5 pyramidal neuron-based generic model is presented in order conceptualize possible mechanistic solution explanatory cul-de-sac. To support argument, review pertinent research compiled associated with from studies where physically invariant perceptual stimuli have underwent alternative interpretation(s) by brain. Recent developments newly emerging field cellular psycho(physio)logy are introduced, offering hypothetical distinguishing subserving content experience and interpretation. single cell-based approach brain process correlates perception added value beyond traditional inter-areal connectivity-based theoretical stances.

Язык: Английский

Процитировано

0
The brain that controls itself DOI Creative Commons
Eli J. Műller, Brandon R. Munn, James M. Shine

и другие.

Current Opinion in Behavioral Sciences, Год журнала: 2025, Номер 63, С. 101499 - 101499

Опубликована: Март 12, 2025

Язык: Английский

Процитировано

0
A burst-dependent thalamocortical substrate for perceptual awareness DOI Creative Commons
Christopher J. Whyte, Eli J. Műller, Jaan Aru

и другие.

PLoS Computational Biology, Год журнала: 2025, Номер 21(4), С. e1012951 - e1012951

Опубликована: Апрель 7, 2025

Contemporary models of perceptual awareness lack tractable neurobiological constraints. Inspired by recent cellular recordings in a mouse model tactile threshold detection, we constructed biophysical that incorporated essential features thalamocortical anatomy and physiology. Our reproduced, mechanistically explains, the key vivo neural behavioural signatures model, as well response to set causal perturbations. We generalised same (with identical parameters) more complex task – visual rivalry found thalamic-mediated mechanism determined dominance. This led generation novel, directly testable, electrophysiological predictions. Analyses based on dynamical systems theory show simulations both detection arises from emergent systems-level dynamics loops.

Язык: Английский

Процитировано

0
Propofol Disrupts the Functional Core-Matrix Architecture of the Thalamus in Humans DOI Creative Commons
Zirui Huang, George A. Mashour, Anthony G. Hudetz

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Янв. 24, 2024

Abstract Research into the role of thalamocortical circuits in anesthesia-induced unconsciousness is difficult due to anatomical and functional complexity. Prior neuroimaging studies have examined either thalamus as a whole or focused on specific subregions, overlooking distinct neuronal subtypes like core matrix cells. We conducted study heathy volunteers magnetic resonance imaging during conscious baseline, deep sedation, recovery. advanced gradient mapping technique delineate geometry circuits, within framework unimodal-transmodal axis cortex. observed significant shift this unconsciousness, marked by dominance unimodal over transmodal geometry. This alteration was closely linked spatial variations density cells thalamus. research bridges cellular systems-level understanding, highlighting crucial thalamic core–matrix architecture understanding neural mechanisms states consciousness.

Язык: Английский

Процитировано

2