Robustness and variability in Caenorhabditis elegans dauer gene expression DOI Creative Commons
Johnny Cruz-Corchado, Abhishiktha Godthi,

Kavinila Selvarasu

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 19, 2024

ABSTRACT Both plasticity and robustness are pervasive features of developmental programs. The dauer in Caenorhabditis elegans is an arrested, hypometabolic alternative to the third larval stage nematode. Dauers undergo dramatic tissue remodeling extensive physiological, metabolic, behavioral, gene expression changes compared conspecifics that continue development can be induced by several adverse environments or genetic mutations act as independent parallel inputs into program. Therefore, induction example phenotypic plasticity. However, whether larvae arrest different environmental triggers invariant varies depending on their route has not been examined. By using RNA-sequencing characterize types computing variance concordance within Gene Ontologies (GO) networks, we find patterns most pathways strongly correlated between larvae, suggestive transcriptional robustness. specific defense pathways, regulating some morphological traits, metabolic differ larvae. We speculate core allows for buffering variation genes involved adaptation, allowing dauers stimuli survive exploit niches.

Язык: Английский

Interleukin-17 as a key player in neuroimmunometabolism DOI
Aaron Douglas,

Brenneth Stevens,

Lydia Lynch

и другие.

Nature Metabolism, Год журнала: 2023, Номер 5(7), С. 1088 - 1100

Опубликована: Июль 20, 2023

Язык: Английский

Процитировано

27
Eukaryotic Elongation Factor 2 Kinase EFK-1/eEF2K promotes starvation resistance by preventing oxidative damage in C. elegans DOI Creative Commons
Junran Yan, Forum Bhanshali,

Chiaki Shuzenji

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 18, 2025

Cells and organisms frequently experience starvation. To survive, they mount an evolutionarily conserved stress response. A vital component in the mammalian starvation response is eukaryotic elongation factor 2 (eEF2) kinase (eEF2K), which suppresses translation by phosphorylating inactivating driver eEF2. C. elegans EFK-1/eEF2K phosphorylates EEF-2/eEF2 on a residue required for survival, but how it promotes survival remains unclear. Surprisingly, we found that eEF2 phosphorylation unchanged starved EFK-1's activity dispensable suggesting efk-1 via noncanonical pathway. We show upregulates transcription of DNA repair pathways, nucleotide excision (NER) base (BER), to promote survival. Furthermore, oxygen consumption ROS production prevent oxidative stress. Thus, enables protecting animals from starvation-induced damage through EEF-2-independent survive activating protective pathways. Here, authors describe defends against long term independently its regulation.

Язык: Английский

Процитировано

0
The many roads to C. elegans dauer arrest: A review and perspective DOI

Kavinila Selvarasu,

Abhishiktha Godthi, Veena Prahlad

и другие.

Journal of Biosciences, Год журнала: 2025, Номер 50(2)

Опубликована: Май 15, 2025

Язык: Английский

Процитировано

0
Robustness and variability in Caenorhabditis elegans dauer gene expression DOI Creative Commons
Johnny Cruz-Corchado, Abhishiktha Godthi,

Kavinila Selvarasu

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 19, 2024

ABSTRACT Both plasticity and robustness are pervasive features of developmental programs. The dauer in Caenorhabditis elegans is an arrested, hypometabolic alternative to the third larval stage nematode. Dauers undergo dramatic tissue remodeling extensive physiological, metabolic, behavioral, gene expression changes compared conspecifics that continue development can be induced by several adverse environments or genetic mutations act as independent parallel inputs into program. Therefore, induction example phenotypic plasticity. However, whether larvae arrest different environmental triggers invariant varies depending on their route has not been examined. By using RNA-sequencing characterize types computing variance concordance within Gene Ontologies (GO) networks, we find patterns most pathways strongly correlated between larvae, suggestive transcriptional robustness. specific defense pathways, regulating some morphological traits, metabolic differ larvae. We speculate core allows for buffering variation genes involved adaptation, allowing dauers stimuli survive exploit niches.

Язык: Английский

Процитировано

1