Springer eBooks, Год журнала: 2024, Номер unknown, С. 625 - 653
Опубликована: Янв. 1, 2024
Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)
Опубликована: Янв. 7, 2025
Abstract The mucosal immune system, as the most extensive peripheral network, serves frontline defense against a myriad of microbial and dietary antigens. It is crucial in preventing pathogen invasion establishing tolerance. A comprehensive understanding immunity essential for developing treatments that can effectively target diseases at their entry points, thereby minimizing overall impact on body. Despite its importance, our knowledge remains incomplete, necessitating further research. outbreak severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has underscored critical role disease prevention treatment. This systematic review focuses dynamic interactions between mucosa-associated lymphoid structures related diseases. We delve into basic functions these tissues during processes explore intricate regulatory networks mechanisms involved. Additionally, we summarize novel therapies clinical research advances immunity-related also addresses challenges vaccines, which aim to induce specific responses while maintaining tolerance non-pathogenic microbes. Innovative therapies, such nanoparticle vaccines inhalable antibodies, show promise enhancing offer potential improved
Язык: Английский
Процитировано
3
Cell Discovery, Год журнала: 2024, Номер 10(1)
Опубликована: Окт. 16, 2024
How immune cells are spatiotemporally coordinated in the lung to effectively monitor, respond to, and resolve infection inflammation primed form needs be fully illustrated. Here we apply immunocartography, a high-resolution technique that integrates spatial single-cell RNA sequencing (scRNA-seq) through deconvolution co-localization analyses, SARS-CoV-2-infected Syrian hamster model. We generate comprehensive transcriptome map of whole process pulmonary from physiological condition, initiation, severe pneumonia natural recovery at organ scale resolution, with 142,965 45 lobes 25 hamsters 5 time points. Integrative analysis identifies alveolar dendritic cell-T cell immunity hubs, where Ccr7
Язык: Английский
Процитировано
9
The Pediatric Infectious Disease Journal, Год журнала: 2024, Номер 43(6), С. 532 - 535
Опубликована: Фев. 29, 2024
This study highlights the importance of human milk in providing anti-severe acute respiratory syndrome coronavirus 2 immunity to newborns. The highest protective activity against COVID-19 was found colostrum from infected mothers. Neutralizing associated with high levels specific IgA. Depletion IgA, but not IgG, samples completely abolished ability neutralize severe 2.
Язык: Английский
Процитировано
5
Nature Communications, Год журнала: 2025, Номер 16(1)
Опубликована: Янв. 2, 2025
Язык: Английский
Процитировано
0
Antiviral Research, Год журнала: 2025, Номер 235, С. 106082 - 106082
Опубликована: Янв. 17, 2025
Язык: Английский
Процитировано
0
PEDIATRICS, Год журнала: 2025, Номер unknown
Опубликована: Апрель 3, 2025
Medical advancements over the last century have improved our ability to treat pediatric infectious diseases, significantly reducing associated morbidity and mortality worldwide. Although vaccines been pivotal in this progress, many viral pathogens still do not currently effective vaccines. The COVID-19 pandemic highlighted need for rapid responses emerging introduced new tools combat them. This review addresses human monoclonal antibodies (mAbs) as a strategy treating preventing infections populations. We discuss previously used available mAbs mAb discovery. address future of therapy by describing novel approaches drug production delivery platforms addition alternative antibody classes. Finally, we challenges limitations development newborns children.
Язык: Английский
Процитировано
0
Veterinary Microbiology, Год журнала: 2025, Номер unknown, С. 110501 - 110501
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Опубликована: Апрель 16, 2025
Intranasal vaccination is an attractive strategy for preventing COVID-19 disease as it stimulates the production of multimeric secretory immunoglobulin A (IgA), predominant antibody isotype in mucosal immune system, at target site severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry. Currently, intranasal vaccine efficacy evaluated based on measurement polyclonal titers nasal lavage fluid. However, how individual IgA protects mucosa from SARS-CoV-2 infection remains to be elucidated. To understand precise contribution and molecular nature induced by vaccines, we developed 99 monoclonal clones 114 or IgG nonmucosal tissues mice that were intranasally immunized with spike protein. The exhibited shared origins common unique somatic mutations related clones, indicating antigen-specific plasma cells originated B stimulated mucosa. Comparing protein binding reactivity, angiotensin-converting enzyme-2-blocking vitro virus neutralization monomeric pairs recognizing different epitopes showed even non-neutralizing IgAs, which represents 70% repertoire, can protect against when expressed IgAs. We also demonstrated administration delivered prophylaxis hamster model reduced infection-induced weight loss. Our investigation first demonstrate function level, showing immunization provide effective immunity inducing IgAs infection.
Язык: Английский
Процитировано
0
Expert Review of Vaccines, Год журнала: 2024, Номер 23(1), С. 362 - 370
Опубликована: Март 6, 2024
Following the coronavirus disease pandemic, respiratory mucosal vaccines that elicit both and systemic immune responses have garnered increasing attention. However, human physiological characteristics pose significant challenges in evaluation of immunity, which directly impedes development application vaccines.
Язык: Английский
Процитировано
2
Clinical Infection in Practice, Год журнала: 2024, Номер 22, С. 100358 - 100358
Опубликована: Апрель 1, 2024
Язык: Английский
Процитировано
2