Endogenous retrovirus HERVH-derived lncRNA UCA1 controls human trophoblast development
Proceedings of the National Academy of Sciences,
Год журнала:
2024,
Номер
121(12)
Опубликована: Март 14, 2024
Endogenous
retroviruses
(ERVs)
are
frequently
reactivated
in
mammalian
placenta.
It
has
been
proposed
that
ERVs
contribute
to
shaping
the
gene
regulatory
network
of
trophoblasts,
dominantly
acting
as
species-
and
placental-specific
enhancers.
However,
whether
how
control
human
trophoblast
development
through
alternative
pathways
remains
poorly
understood.
Besides
well-recognized
function
endogenous
retrovirus-H
(HERVH)
maintaining
pluripotency
early
epiblast,
here
we
present
a
unique
role
HERVH
on
lineage
development.
We
found
LTR7C/HERVH
subfamily
exhibits
an
accessible
chromatin
state
lineage.
Particularly,
LTR7C/HERVH-derived
Язык: Английский
Trophoblast Fusion in Hypertensive Disorders of Pregnancy and Preeclampsia
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 2859 - 2859
Опубликована: Март 21, 2025
Trophoblast
fusion
into
the
multinucleated
syncytiotrophoblast
(SCT)
appears
as
an
inescapable
feature
of
placentation
in
mammals
and
other
viviparous
species.
The
trophoblast
cells
underlying
syncytium
are
considered
a
reservoir
for
restoration
aging
peripheric
structure.
transition
from
trophoblasts
to
SCTs
has
be
tightly
regulated,
could
altered
by
genetic
anomalies
or
environmental
exposure.
resulting
defective
placental
function
one
causes
major
diseases,
such
preeclampsia
(PE)
Intra-Uterine
Growth
Restriction
(IUGR).
This
review
attempts
take
stock
current
knowledge
about
mechanisms
their
deregulations.
Язык: Английский
Transcription of Endogenous Retroviruses: Broad and Precise Mechanisms of Control
Viruses,
Год журнала:
2024,
Номер
16(8), С. 1312 - 1312
Опубликована: Авг. 17, 2024
Endogenous
retroviruses
(ERVs)
are
the
remnants
of
retroviral
germline
infections
and
highly
abundant
in
genomes
vertebrates.
At
one
time
considered
to
be
nothing
more
than
inert
‘junk’
within
genomes,
ERVs
have
been
tolerated
host
over
vast
timescales,
their
study
continues
reveal
complex
co-evolutionary
histories
respective
species.
For
example,
multiple
instances
characterized
having
‘borrowed’
for
normal
physiology,
from
single
copies
ones
involved
various
regulatory
networks
such
as
innate
immunity
during
early
development.
Within
cell,
accessibility
is
normally
tightly
controlled
by
epigenetic
mechanisms
DNA
methylation
or
histone
modifications.
However,
these
silencing
reversible,
alterations
chromatin
landscape
can
thus
lead
aberrant
expression,
observed
abnormal
cellular
environments
tumors.
In
this
review,
we
focus
on
ERV
transcriptional
control
draw
parallels
distinctions
concerning
loss
regulation
disease,
well
precise
Язык: Английский
Deciphering human endogenous retrovirus expression in colorectal cancers: exploratory analysis regarding prognostic value in liver metastases
EBioMedicine,
Год журнала:
2025,
Номер
116, С. 105727 - 105727
Опубликована: Май 16, 2025
Язык: Английский
A tale of a hidden family of genetic immigrants
Microbes and Infection,
Год журнала:
2024,
Номер
unknown, С. 105387 - 105387
Опубликована: Июнь 1, 2024
Though
not
usual
for
the
editors
of
a
scientific
journal
to
ask
that
story
be
told
its
readers,
this
special
issue
is
offering
an
opportunity
pay
tribute
all
those
who
have
made
it
possible
long
journey
open
up
many
research
avenues,
access
discoveries
what
was
known
and
understanding
unveiled
in
field
human
endogenous
retroviruses.
In
particular,
beyond
simple
fortuitous
association,
show
their
pathogenic
involvement
certain
diseases
whose
causality
has
been
subject
numerous
variable
hypotheses.
Язык: Английский
Repetitive Sequence Stability in Embryonic Stem Cells
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8819 - 8819
Опубликована: Авг. 13, 2024
Repetitive
sequences
play
an
indispensable
role
in
gene
expression,
transcriptional
regulation,
and
chromosome
arrangements
through
trans
cis
regulation.
In
this
review,
focusing
on
recent
advances,
we
summarize
the
epigenetic
regulatory
mechanisms
of
repetitive
embryonic
stem
cells.
We
aim
to
bridge
knowledge
gap
by
discussing
DNA
damage
repair
pathway
choices
summarizing
significance
chromatin
organization
response
damage.
By
consolidating
these
insights,
underscore
critical
relationship
between
stability
early
development,
seeking
provide
a
deeper
understanding
sequence
setting
stage
for
further
research
potential
therapeutic
strategies
developmental
biology
regenerative
medicine.
Язык: Английский
Functional Bidirectionality of ERV-Derived Long Non-Coding RNAs in Humans
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10481 - 10481
Опубликована: Сен. 29, 2024
Human
endogenous
retroviruses
(HERVs)
are
widely
recognized
as
the
result
of
exogenous
infecting
ancestral
germline,
stabilizing
integration
and
vertical
transmission
during
human
genetic
evolution.
To
date,
(ERVs)
appear
to
have
been
selected
for
physiological
functions
with
loss
retrotransposable
capabilities.
ERV
elements
were
previously
regarded
junk
DNA
a
long
time.
Since
then,
aberrant
activation
expression
ERVs
observed
in
development
many
kinds
diseases,
their
role
has
explored
variety
disorders
such
cancer.
The
results
show
that
specific
play
respective
crucial
roles.
Among
them,
non-coding
RNAs
(lncRNAs)
transcribed
from
long-terminal
repeat
regions
often
key
factors.
lncRNAs
over
200
nucleotides
size
typically
bind
DNA,
RNA,
proteins
perform
biological
functions.
Dysregulated
implicated
diseases.
In
particular,
studies
shown
some
ERV-derived
tumor-suppressive
or
oncogenic
effect,
displaying
significant
functional
bidirectionality.
Therefore,
theses
promising
future
novel
biomarkers
therapeutic
targets
explore
concise
relationship
between
cancers.
this
review,
we
first
summarize
regulation,
mainly
including
immunomodulation,
maintenance
pluripotency,
erythropoiesis.
addition,
pathological
regulation
examples
leading
carcinogenesis
highlighted,
mechanisms
occurrence
discussed.
Язык: Английский