Contributions of short- and long-range white matter tracts in dynamic compensation with aging DOI
Priyanka Chakraborty, Suman Saha, Gustavo Deco

и другие.

Cerebral Cortex, Год журнала: 2024, Номер unknown

Опубликована: Дек. 13, 2024

Abstract Optimal brain function is shaped by a combination of global information integration, facilitated long-range connections, and local processing, which relies on short-range connections underlying biological factors. With aging, anatomical connectivity undergoes significant deterioration, affects the brain’s overall function. Despite structural loss, previous research has shown that normative patterns functions remain intact across lifespan, defined as compensatory mechanism aging brain. However, crucial components in guiding preservation dynamical complexity mechanisms uncovered. Moreover, it remains largely unknown how readjusts its parameters to maintain optimal dynamics with age; this work, we provide parsimonious using whole-brain generative model uncover role sub-communities comprised driving dynamic compensation process We utilize two neuroimaging datasets demonstrate short- white matter tracts affect mechanisms. unveil their modulation intrinsic scaling parameters, such coupling strength conduction delay, via personalized large-scale model. Our key finding suggests predominantly amplify age, potentially representing an epiphenomenon mechanism. This mechanistically explains significance compensating for major loss during aging. insight could help identify alternative avenues address aging-related diseases where are significantly deteriorated.

Язык: Английский

In vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth DOI Creative Commons
Shaoshi Zhang, Bart Larsen, Valerie J. Sydnor

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(23)

Опубликована: Май 30, 2024

A balanced excitation-inhibition ratio (E/I ratio) is critical for healthy brain function. Normative development of cortex-wide E/I remains unknown. Here, we noninvasively estimate a putative marker whole-cortex by fitting large-scale biophysically plausible circuit model to resting-state functional MRI (fMRI) data. We first confirm that our generates realistic dynamics in the Human Connectome Project. Next, show estimated sensitive gamma-aminobutyric acid (GABA) agonist benzodiazepine alprazolam during fMRI. Alprazolam-induced changes are spatially consistent with positron emission tomography measurement receptor density. then investigate relationship between and neurodevelopment. find declines heterogeneously across cerebral cortex youth, greatest reduction occurring sensorimotor systems relative association systems. Importantly, among children same chronological age, lower (especially cortex) linked better cognitive performance. This result replicated North American (8.2 23.0 y old) Asian (7.2 7.9 cohorts, suggesting more mature indexes improved cognition normative development. Overall, findings open door studying how disrupted trajectories may lead dysfunction psychopathology emerges youth.

Язык: Английский

Процитировано

18
The brain’s action-mode network DOI
Nico U.F. Dosenbach,

Marcus E. Raichle,

Evan M. Gordon

и другие.

Nature reviews. Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

Язык: Английский

Процитировано

17
Antisocial personality disorder:Failure to balance excitation/inhibition? DOI Creative Commons
Klaus‐Peter Lesch, Nikita Gorbunov

Neuropharmacology, Год журнала: 2025, Номер unknown, С. 110321 - 110321

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
A sensorimotor-association axis of thalamocortical connection development DOI Creative Commons
Valerie J. Sydnor, Joëlle Bagautdinova,

Bart Larsen

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 14, 2024

Human cortical development follows a sensorimotor-to-association sequence during childhood and adolescence

Язык: Английский

Процитировано

3
The level of cognitive functioning in school-aged children is predicted by resting EEG Directed Phase Lag Index DOI Creative Commons
Audrey-Rose Charlebois-Poirier,

Saeideh Davoudi,

Ève Lalancette

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 9, 2025

Abstract Quantifying cognitive potential relies on psychometric measures that do not directly reflect cortical activity. While the relationship between ability and resting state EEG signal dynamics has been extensively studied in children with below-average performances, there remains a paucity of research focusing individuals normal to above-average functioning. This study aimed elucidate aged four 12 years across potential. Our findings indicate complexity, as measured by Multiscale Entropy (MSE), was significantly predictive level However, utilizing Directed Phase Lag Index (DPLI) an effective connectivity measure, we observed consistent patterns information flow anterior posterior regions. Fronto-parietal well local were seen most functions. Moreover, specific obtained for each intellectual quotient index (namely verbal comprehension, visuospatial, fluid reasoning, processing speed indexes full-scale quotient). These results underscore presence long-range connections support fronto-parietal theories abilities within brain children.

Язык: Английский

Процитировано

0
Metacognition in the listening brain DOI Creative Commons
Jonas Obleser

Trends in Neurosciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

How do you know have heard right? Metacognition, the ability to assess and monitor one's own cognitive state, is key understanding human communication in complex environments. However, foundational role of metacognition hearing only beginning be explored, neuroscience behind it an emerging field: how does confidence express neural dynamics listening brain? What known about auditory metaperceptual alterations as a hallmark phenomenon psychosis, dementia, or loss? Building on Bayesian ideas perception neuroscience, 'meta-listening' offers framework for more comprehensive research into humans non-humans shapes brain.

Язык: Английский

Процитировано

0
Heterochronous laminar maturation in the human prefrontal cortex DOI Creative Commons
Valerie J. Sydnor, Daniel Petrie, Shane D. McKeon

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 30, 2025

The human prefrontal cortex (PFC) exhibits markedly protracted developmental plasticity, yet whether reductions in plasticity occur synchronously across cortical layers is unclear. Animal studies have shown that intracortical myelin consolidates neural circuits to close periods of plasticity. Here, we use quantitative imaging collected from youth (ages 10-32 years) at ultra-high field (7T) investigate deep and superficial PFC exhibit different timeframes We find matures along a deep-to-superficial axis the PFC; this maturational timing expressed extent cytoarchitecturally distinct regions frontal hierarchy. By integrating mapping with electroencephalogram cognitive phenotyping, provide evidence dissociably impact timescales activity, task learning rates, processing speed. Heterochronous maturation an underrecognized mechanism through which association balances cognitively-relevant increases circuit stability efficiency extended neuroplasticity.

Язык: Английский

Процитировано

0
Assessing neurocognitive maturation in early adolescence based on baby and adult functional brain landscapes DOI Creative Commons
Omid Kardan, Natasha N. Jones, Muriah D. Wheelock

и другие.

Developmental Cognitive Neuroscience, Год журнала: 2025, Номер 73, С. 101543 - 101543

Опубликована: Март 6, 2025

Adolescence is a period of growth in cognitive performance and functioning. Recently, data-driven measures brain-age gap, which can index decline older populations, have been utilized adolescent data with mixed findings. Instead using approach, here we assess the maturation status brain functional landscape early adolescence by directly comparing an individual's resting-state connectivity (rsFC) to canonical early-life adulthood communities. Specifically, hypothesized that degree youth's connectome better captured adult networks compared infant/toddler predictive their development. To test this hypothesis across individuals longitudinally, Adolescent Brain Cognitive Development (ABCD) Study at baseline (9-10 years; n = 6469) 2-year-follow-up (Y2: 11-12 5060). Adjusted for demographic factors, our anchored rsFC score (AFC) was associated task both within participants. AFC related age aging youth, change statistically mediated age-related performance. In conclusion, showed model-fitting-free rest baby landscapes predicts development youth.

Язык: Английский

Процитировано

0
Distinct Developmental Programs Displayed by the Xenopus Tadpole Accessory Optic System and Retinotectal Projection DOI
Uwemedimo G. Udoh, Kaiyuan Zheng,

John R. Bruno

и другие.

Developmental Neurobiology, Год журнала: 2025, Номер 85(3)

Опубликована: Май 8, 2025

ABSTRACT The retinotectal projection, the direct synapse between retinal ganglion cells (RGCs) of eye and tectal neurons optic tectum, is a major component amphibian visual system. A model circuit formation, this projection has been studied in detail. There are, however, other retinorecipient targets that also comprise system such as pretectum ventral midbrain tegmentum. Understanding how these components form function will lead to more comprehensive understanding system, whole, assembles functions. Toward aim, here we describe functional development Xenopus tadpole accessory (AOS), synaptic connection RGC axons basal nucleus AOS highly conserved across vertebrates. It functions sensory side optokinetic optomotor reflexes, compensatory body movements, respectively, stabilize scene organism moves through it. Using an isolated brain preparation whole‐cell electrophysiological approaches, compared projection. We found two retinofugal projections display distinct developmental programs, which appear mirror their different Retinotectal synapses moved dynamic phase previously described NMDA receptor‐dependent refinement, process known sharpen retinotopic map thereby acuity. In contrast, appeared stable activity independent development, indicative hardwired circuit, built support reflexive behaviors.

Язык: Английский

Процитировано

0
Virtual Brain Inference (VBI): A flexible and integrative toolkit for efficient probabilistic inference on virtual brain models DOI Open Access
Abolfazl Ziaeemehr, Marmaduke Woodman, Lia Domide

и другие.

Опубликована: Май 21, 2025

Abstract Network neuroscience has proven essential for understanding the principles and mechanisms underlying complex brain (dys)function cognition. In this context, whole-brain network modeling–also known as virtual modeling–combines computational models of dynamics (placed at each node) with individual imaging data (to coordinate connect nodes), advancing our its neurobiological underpinnings. However, there remains a critical need automated model inversion tools to estimate control (bifurcation) parameters large scales across neuroimaging modalities, given their varying spatio-temporal resolutions. This study aims address gap by introducing flexible integrative toolkit efficient Bayesian inference on models, called Virtual Brain Inference (<monospace>VBI</monospace>). open-source provides fast simulations, taxonomy feature extraction, storage loading, probabilistic machine learning algorithms, enabling biophysically interpretable from non-invasive invasive recordings. Through in-silico testing, we demonstrate accuracy reliability commonly used associated data. <monospace>VBI</monospace> shows potential improve hypothesis evaluation in through uncertainty quantification, contribute advances precision medicine enhancing predictive power models.

Язык: Английский

Процитировано

0