Pharmaceutics,
Год журнала:
2024,
Номер
16(7), С. 877 - 877
Опубликована: Июнь 29, 2024
Chemotherapy
is
a
known
treatment
modality
that
improves
the
long-term
survival
of
breast
cancer
patients.
However,
due
to
resistance
numerous
anticancer
drugs,
alternative
chemotherapeutic
strategies
are
required.
Regarding
antimetabolic
several
compounds
have
proven
properties,
such
as
statins.
The
present
study
aimed
investigate
in
vitro
effects
V9302,
competitive
antagonist
glutamine
flux,
on
different
subtypes
cancers
(estrogen,
progesterone,
and
HER2
receptor-positive
or
negative,
Pgp-negative
Pgp-overexpressing).
interactions
V9302
with
standard
drugs
(doxorubicin
cisplatin)
were
also
determined
by
MTT
staining
cell
lines.
Furthermore,
influence
cycle
MCF-7
its
Pgp-overexpressing
counterpart
KCR
was
monitored
flow
cytometry.
It
shown
exerted
synergistic
doxorubicin
all
In
analysis,
line
more
sensitive
V9302.
After
48
h,
proliferation
completely
blocked,
elevated
G1,
suppressed
S,
decreased
G2/M
could
be
detected.
Inhibition
glutamate
transport
can
assumed
block
related
Pgp.
Proceedings of the National Academy of Sciences,
Год журнала:
2024,
Номер
121(13)
Опубликована: Март 21, 2024
Polyamines
are
a
class
of
small
polycationic
alkylamines
that
play
essential
roles
in
both
normal
and
cancer
cell
growth.
Polyamine
metabolism
is
frequently
dysregulated
considered
therapeutic
target
cancer.
However,
targeting
polyamine
as
monotherapy
often
exhibits
limited
efficacy,
the
underlying
mechanisms
incompletely
understood.
Here
we
report
activation
catabolism
promotes
glutamine
metabolism,
leading
to
targetable
vulnerability
lung
Genetic
pharmacological
spermidine/spermine
N1-acetyltransferase
1
(SAT1),
rate-limiting
enzyme
catabolism,
enhances
conversion
glutamate
subsequent
glutathione
(GSH)
synthesis.
This
metabolic
rewiring
ameliorates
oxidative
stress
support
proliferation
survival.
Simultaneous
limitation
SAT1
result
ROS
accumulation,
growth
inhibition,
death.
Importantly,
inhibition
either
one
transport,
glutaminase,
or
GSH
biosynthesis
combination
with
synergistically
suppresses
xenograft
tumor
formation.
Together,
this
study
unveils
previously
unappreciated
functional
interconnection
between
establishes
cotargeting
strategies
potential
therapeutics
Biomolecules,
Год журнала:
2025,
Номер
15(2), С. 288 - 288
Опубликована: Фев. 14, 2025
Retinal
Müller
glial
cells
(RMG)
play
a
crucial
role
in
retinal
neuroinflammation,
including
autoimmune
uveitis.
Increasing
evidence
supports
their
function
as
active
modulators
of
immune
responses
and
potential
atypical
antigen-presenting
(APCs).
To
further
investigate
this
hypothesis,
we
conducted
differential
proteome
analysis
primary
equine
RMG
from
healthy
controls
horses
with
recurrent
uveitis
(ERU),
spontaneous
model
This
identified
310
proteins
abundance.
Among
these,
the
Major
Histocompatibility
Complex
(MHC)
class
II
enzyme
Arginase
1
(ARG1)
were
significantly
enriched
uveitis-affected
horses,
whereas
Mannose
Receptor
C-type
2
(MRC2)
its
interactor
Thrombospondin
(THBS1)
more
abundant
RMG.
The
detection
MHC
RMG,
consistent
previous
studies,
validates
robustness
our
approach.
Furthermore,
identification
ARG1
MRC2,
together
THBS1,
provides
new
insights
into
immunomodulatory
properties
Immunohistochemical
analyses
confirmed
proteomic
findings
revealed
spatial
distribution
MRC2.
MRC2
are
thus
markers
for
neuroinflammatory
or
physiological
milieu
highlight
differences
particularly
antigen
presentation.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 10, 2025
Tumor
metabolic
reprogramming
is
a
highly
complex
process
that
enables
tumor
survival
in
the
presence
of
limited
nutrients,
involving
multiple
signaling
pathways,
non-coding
RNAs
(ncRNAs),
and
transcription
factors.
Lately,
glutamine
has
been
found
to
enhance
growth,
spread,
drug
resistance
cancer
cells,
while
also
fostering
an
immunosuppressive
microenvironment
aids
development.
However,
some
tumors,
such
as
pancreatic
melanoma,
additional
can
inhibit
proliferation
this
mechanism
closely
related
regulation
immune
microenvironment.
Therefore,
further
exploration
metabolism
tumors
essential
for
understanding
pathogenesis
developing
new
metabolically
targeted
therapies.
We
systematically
review
latest
research
on
its
role
system
regulation.
Additionally,
we
clinical
progress
therapies
their
application
combination
with
current
anti-tumor
treatments.
Ultimately,
address
challenges
prospects
involved
anti-cancer
strategies
aimed
at
metabolism.
A
pathway
frequently
altered
in
cancer
is
glutaminolysis
where
glutaminase
(GA)
catalyses
the
main
step:
deamidation
of
glutamine
to
form
glutamate
and
ammonium.
There
are
two
types
GA
isozymes,
named
GLS
GLS2,
which
differ
considerably
their
expression
patterns
can
even
perform
opposing
roles
cancer.
correlates
with
tumor
growth
proliferation,
while
GLS2
may
function
as
a
context-dependent
suppressor.
However,
both
isoenzymes
have
been
described
essential
molecules
handling
oxidant
stress
because
involvement
glutathione
production.
We
reviewed
literature
highlight
critical
restrain
ROS
regulate
cellular
signaling
metabolic
due
indirect
antioxidant
enzymes
also
by
modulating
reductive
carboxylation
ferroptosis.
Blocking
activity
appears
be
potential
strategy
dual
activate
ferroptosis
inhibit
cell
ROS-mediated
mechanism.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 18, 2024
Lung
cancer
has
posed
a
significant
challenge
to
global
health,
and
related
study
been
hot
topic
in
oncology.
This
article
focuses
on
metabolic
reprogramming
of
lung
cells,
process
adapt
energy
demands
biosynthetic
needs,
supporting
the
proliferation
development
tumor
cells.
In
this
study,
latest
studies
metabolism
were
reviewed,
including
impact
products
enzymes
occurrence
cancer,
as
well
progress
field
treatment
targeting
relevant
pathways.
provides
some
promising
potential
directions
into
exploring
helps
researchers
better
understand
cancer.
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Abstract
Ionizing
radiation
is
effective
in
combating
cancer
but
inflicts
severe
damage
on
the
oral
mucosa.
The
mechanisms
behind
this
remain
unclear,
and
current
treatment
modalities
are
primarily
palliative.
This
study
revealed
that
ferroptosis
predominant
reason
for
oral-radiation
depletion
of
mucosal
epithelial
cells.
More
importantly,
compensatory
activated
organism
during
early
stage
after
exposure.
These
arise
from
metabolic
support
provided
by
fibroblasts.
In
post-radiation
stage,
fibroblasts
supply
polyamines,
which
readily
absorbed
basal
cells,
protecting
them
ferroptosis.
Local
supplementation
polyamines
effectively
mitigates
damage.
emphasizes
important
role
fibroblast-mediated
mucosa
radiation-induced
Results
provide
new
insights
into
radiation-related
diseases
enhancing
self-protective
responses
living
organisms.
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 265 - 265
Опубликована: Фев. 25, 2025
Bee
pollen
(BP)
is
one
of
the
richest
known
natural
resources
micronutrients
and
bioactive
phytochemicals.
Some
captivating
bioactivities
BP
compounds,
although
being
largely
investigated
for
latter
as
individual
molecules,
remain
very
scarcely
or
completely
uninvestigated
in
bee
a
whole
product.
Among
most
intriguing
these
bioactivities,
we
identified
ferroptosis
major
one.
Ferroptosis,
recently
discovered
form
cell
death
(connecting
oxidative
stress
inflammation),
complex
pathophysiological
process
crucial
perplexing
events
current
challenging
human
diseases
such
cancer,
neurodegeneration,
general
aging
diseases.
Many
compounds
were
found
to
intricately
modulate
depending
on
cellular
context
by
inducing
this
mechanism
malignant
cells
preventing
it
non-malignant
cells.
Since
research
both
fields,
i.e.,
ferroptosis,
still
recent,
deemed
necessary
undertake
review
figure
out
extent
potential
modulating
mechanisms.
Our
proved
that
wide
range
(polyphenols,
phenolamides,
carotenoids,
vitamins,
minerals,
others)
substantially
diverse
Accordingly,
phytochemicals
nutrients
showed
interesting
preclinical
studies
lead
ferroptosis-mediated
outcomes
important
processes,
including
many
aging-related
disorders.
One
paramount
challenges
be
resolved
determine
how
different
act
biological
contexts,
either
through
synergistic
antagonistic
behaviors.
We
hope
our
work
constitutes
valuable
incentive
future
investigations
promising
relevant
avenue.
Abstract
Lung
cancer
remains
one
of
the
deadliest
cancers
globally,
which
may
be
attributed
in
part
to
a
limited
understanding
its
development.
Therefore,
exploration
fundamental
processes
lung
and
innovative
therapies
is
imminent.
Recently,
immunotherapy
has
become
crucial
topic
interest,
it
pertains
metabolism
tumor
microenvironment.
In
particular,
glutamine
plays
pivotal
role
immunotherapy.
This
review
summarizes
crosstalk
between
immune
microenvironment,
explores
potential
strategies
as
an
enhancement
It
also
discusses
traditional
Chinese
medicine
regulating
offer
valuable
insights
promising
directions
for
future
studies
on
this
subject.
